Histidinol dehydrogenase - Caulobacter crescentus

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Reviewed, UniProtKB/Swiss-Prot Q9A5V1 (HISX_CAUCR)

Last modified November 3, 2009. Version 54. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23

Gene names

Name:	hisD
Ordered Locus Names:	CC_2346

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD⁺ = L-histidine + 2 NADH. HAMAP MF_01024
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

428

Histidinol dehydrogenase HAMAP MF_01024

PRO_0000135753

Sites

Active site

1

Proton acceptor By similarity

Active site

1

Proton acceptor By similarity

Metal binding

1

Zinc By similarity

Metal binding

1

Zinc By similarity

Metal binding

1

Zinc By similarity

Metal binding

1

Zinc By similarity

Binding site

1

NAD By similarity

Binding site

1

NAD By similarity

Binding site

1

NAD By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9A5V1-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 89F4ECF58D67F2F2
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428

45,154

        10         20         30         40         50         60 
MRRFLFSDPD FQTAFKAFLD ERRGSPADVD AAVAGVLEAV RTQGIEALLD YSRRFDKVDL 

        70         80         90        100        110        120 
TAETIRVTAE EIEAGAAETP ADVREAIAFA AARIRAYHSR QRPADQAWTD EAGVELGWRW 

       130        140        150        160        170        180 
TPLEAVGVYV PGGRAAYPST VLMNAVPAQV AGVDRIAMVT PPGKLQPAVL AAAKEAGVTE 

       190        200        210        220        230        240 
IWRVGGAQAV AALAYGAGPI QPVDKIVGPG NAYVTAAKRR LYGVVGIDAL AGPSEIVVVA 

       250        260        270        280        290        300 
DNKNNPDWIA ADLLSQAEHD PAAQSILITD DEAFAAAVEQ AIAERLKTLA TGEDAAASWR 

       310        320        330        340        350        360 
DHGAVIIAPL DESPALVDAI APEHVEFALD NPERLSDRVR HAGAIFLGRV TPEAIGDYVA 

       370        380        390        400        410        420 
GSNHVLPTSR AARFQSGLSI YDFIKRTSIV KCDPASFAVL GPHTVALAKA EGLPAHALSA 


SVRLPSGD

Cross-references

Sequence databases
	AE005673 Genomic DNA. Translation: AAK24317.1.
PIR	A87540.
RefSeq	NP_421149.1.
3D structure databases
HSSP	HSSP built from PDB template 1K75 based on UniProtKB P06988.
ModBase	Search...
Genome annotation databases
GeneID	943550.
GenomeReviews	Gene locus CC_2346 in contig AE005673_GR.
KEGG	ccr:CC_2346.
NMPDR	fig\|190650.1.peg.2329.
TIGR	CC_2346.
Phylogenomic databases
HOGENOM	Q9A5V1.
OMA	LDAHKNA.
Enzyme and pathway databases
BRENDA	1.1.1.23. 2191.
Family and domain databases
HAMAP	MF_01024. [Tree]
InterPro	IPR001692. Histidinol_DH_CS. IPR012131. Hstdl_DH_prok-type. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX_CAUCR

Accession

Primary (citable) accession number: Q9A5V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents