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Q9A5C8 (Q9A5C8_CAUCR) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:CC_2522 EMBL AAK24493.1
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP] EMBL AAK24493.1
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
Q9A5C8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 43776B86ADE75BA7

FASTA40345,036
        10         20         30         40         50         60 
MAKIKVANPV VDMDGDEMTR IIWKLIKDKL IFPYLDLELD YYDLSVENRD ATDDQVTIDA 

        70         80         90        100        110        120 
ANATKKHGVA VKCATITPDE QRVEEFKLKK MWKSPNGTIR NILGGVIFRE PIICQNVPRL 

       130        140        150        160        170        180 
VPGWTQPIIV GRHAFGDQYR ATDFKFPGKG TLSIKFVGED GQTIEHEVFK APDAGVAMAM 

       190        200        210        220        230        240 
YNLDESIRDF AHASFAYGLN RGYPVYLSTK NTILKAYDGR FKDIFQEIYD AEYAEKFKAA 

       250        260        270        280        290        300 
GIHYEHRLID DMVASALKWS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLMTPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRQHQKG ESTSTNSIAS IFAWTRGLAH RAKLDDNQDL ANFAATLEKV 

       370        380        390        400 
CIDTVESGYM TKDLALLVGD KQGWLTTEGF LDKIDENLKK AMA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK24493.1.
PIRA87562.
RefSeqNP_421325.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9A5C8.
SMRQ9A5C8. Positions 2-402.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK24493; AAK24493; CC_2522.
GeneID943621.
KEGGccr:CC_2522.
PATRIC21302074. VBICauCre124313_2538.

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.
OMAKNTIMKV.
OrthoDBEOG628F3X.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ9A5C8_CAUCR
AccessionPrimary (citable) accession number: Q9A5C8
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)