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Q9A5C8

- Q9A5C8_CAUCR

UniProt

Q9A5C8 - Q9A5C8_CAUCR

Protein

Isocitrate dehydrogenase [NADP]

Gene

CC_2522

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADP
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADP
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADP
    Nucleotide bindingi308 – 3136NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:CC_2522Imported
    OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)Imported
    Taxonomic identifieri190650 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001816: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliQ9A5C8.
    SMRiQ9A5C8. Positions 2-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiKNTIMKV.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9A5C8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVANPV VDMDGDEMTR IIWKLIKDKL IFPYLDLELD YYDLSVENRD    50
    ATDDQVTIDA ANATKKHGVA VKCATITPDE QRVEEFKLKK MWKSPNGTIR 100
    NILGGVIFRE PIICQNVPRL VPGWTQPIIV GRHAFGDQYR ATDFKFPGKG 150
    TLSIKFVGED GQTIEHEVFK APDAGVAMAM YNLDESIRDF AHASFAYGLN 200
    RGYPVYLSTK NTILKAYDGR FKDIFQEIYD AEYAEKFKAA GIHYEHRLID 250
    DMVASALKWS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLMTPDGKT 300
    VEAEAAHGTV TRHYRQHQKG ESTSTNSIAS IFAWTRGLAH RAKLDDNQDL 350
    ANFAATLEKV CIDTVESGYM TKDLALLVGD KQGWLTTEGF LDKIDENLKK 400
    AMA 403
    Length:403
    Mass (Da):45,036
    Last modified:June 1, 2001 - v1
    Checksum:i43776B86ADE75BA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK24493.1.
    PIRiA87562.
    RefSeqiNP_421325.1. NC_002696.2.

    Genome annotation databases

    EnsemblBacteriaiAAK24493; AAK24493; CC_2522.
    GeneIDi943621.
    KEGGiccr:CC_2522.
    PATRICi21302074. VBICauCre124313_2538.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK24493.1 .
    PIRi A87562.
    RefSeqi NP_421325.1. NC_002696.2.

    3D structure databases

    ProteinModelPortali Q9A5C8.
    SMRi Q9A5C8. Positions 2-402.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK24493 ; AAK24493 ; CC_2522 .
    GeneIDi 943621.
    KEGGi ccr:CC_2522.
    PATRICi 21302074. VBICauCre124313_2538.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi KNTIMKV.
    OrthoDBi EOG628F3X.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19089 / CB15Imported.

    Entry informationi

    Entry nameiQ9A5C8_CAUCR
    AccessioniPrimary (citable) accession number: Q9A5C8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3