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Q9A5C8

- Q9A5C8_CAUCR

UniProt

Q9A5C8 - Q9A5C8_CAUCR

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Protein

Isocitrate dehydrogenase [NADP]

Gene

CC_2522

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADP
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADP
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP
Nucleotide bindingi308 – 3136NADP

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:CC_2522Imported
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)Imported
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816: Chromosome

Structurei

3D structure databases

ProteinModelPortaliQ9A5C8.
SMRiQ9A5C8. Positions 2-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9A5C8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVANPV VDMDGDEMTR IIWKLIKDKL IFPYLDLELD YYDLSVENRD
60 70 80 90 100
ATDDQVTIDA ANATKKHGVA VKCATITPDE QRVEEFKLKK MWKSPNGTIR
110 120 130 140 150
NILGGVIFRE PIICQNVPRL VPGWTQPIIV GRHAFGDQYR ATDFKFPGKG
160 170 180 190 200
TLSIKFVGED GQTIEHEVFK APDAGVAMAM YNLDESIRDF AHASFAYGLN
210 220 230 240 250
RGYPVYLSTK NTILKAYDGR FKDIFQEIYD AEYAEKFKAA GIHYEHRLID
260 270 280 290 300
DMVASALKWS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLMTPDGKT
310 320 330 340 350
VEAEAAHGTV TRHYRQHQKG ESTSTNSIAS IFAWTRGLAH RAKLDDNQDL
360 370 380 390 400
ANFAATLEKV CIDTVESGYM TKDLALLVGD KQGWLTTEGF LDKIDENLKK

AMA
Length:403
Mass (Da):45,036
Last modified:June 1, 2001 - v1
Checksum:i43776B86ADE75BA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005673 Genomic DNA. Translation: AAK24493.1.
PIRiA87562.
RefSeqiNP_421325.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK24493; AAK24493; CC_2522.
GeneIDi943621.
KEGGiccr:CC_2522.
PATRICi21302074. VBICauCre124313_2538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005673 Genomic DNA. Translation: AAK24493.1 .
PIRi A87562.
RefSeqi NP_421325.1. NC_002696.2.

3D structure databases

ProteinModelPortali Q9A5C8.
SMRi Q9A5C8. Positions 2-402.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK24493 ; AAK24493 ; CC_2522 .
GeneIDi 943621.
KEGGi ccr:CC_2522.
PATRICi 21302074. VBICauCre124313_2538.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15Imported.

Entry informationi

Entry nameiQ9A5C8_CAUCR
AccessioniPrimary (citable) accession number: Q9A5C8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3