ID   HGD_CAUCR               Reviewed;         425 AA.
AC   Q9A5B8;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   05-MAY-2009, entry version 46.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=CC_2532;
OS   Caulobacter crescentus (Caulobacter vibrioides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=155892;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   MEDLINE=21173698; PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H.,
RA   Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J.,
RA   Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J.,
RA   Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L.,
RA   Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   EMBL; AE005673; AAK24503.1; -; Genomic_DNA.
DR   PIR; C87563; C87563.
DR   RefSeq; NP_421335.1; -.
DR   HSSP; Q93099; 1EYB.
DR   GeneID; 943950; -.
DR   GenomeReviews; AE005673_GR; CC_2532.
DR   KEGG; ccr:CC_2532; -.
DR   NMPDR; fig|190650.1.peg.2515; -.
DR   TIGR; CC_2532; -.
DR   HOGENOM; Q9A5B8; -.
DR   OMA; Q9A5B8; HRNCMSE.
DR   BRENDA; 1.13.11.5; 2191.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    425       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_0000220247.
FT   METAL       326    326       Iron (By similarity).
FT   METAL       332    332       Iron (By similarity).
FT   METAL       362    362       Iron (By similarity).
SQ   SEQUENCE   425 AA;  46607 MW;  B61AE29016AD9C27 CRC64;
     MDLRYQTGFG SYFETEAHPG ALPVGRNSPQ KVPFGLYAEQ LSGSAFTAPR HENRRTWLYR
     LRPSAGHEAY QPYAQDKLVS AFPGPATPNR LRWSPLEIPA APTDFVDGLV SLAGNADAAT
     LGGIAAHVYL VNVSMKNRVF YNADGEMLIV PQMGELTLVT EMGVLKAGPG HIAVIPRGVR
     FRVEVEGPAR GYVCENYGAA FRLPELGPIG ANGLANPRDF EAPVAAFEDI DTPTQVIQKF
     QGALWAATWD HSPLDVVAWH GNLTPYRYDL SRFNTINTVS YDHPDPSIFT VLTSPSDTPG
     TANCDFVIFP PRWMVAEDTF RPPWFHRNVM SEFMGLIHGA YDAKAGGFVP GGASLHNCMS
     DHGPDVASHK KATEVVLAPH KIDGTMAFMF ESRWVFRPTH LALESAALQS DYDACWTGFP
     KARLS
//