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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Phenylalanine-4-hydroxylase (phhA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Homogentisate 1,2-dioxygenase (hmgA)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei283Proton acceptorUniRule annotation1
Metal bindingi326IronUniRule annotation1
Metal bindingi332IronUniRule annotation1
Binding sitei341homogentisateUniRule annotation1
Metal bindingi362IronUniRule annotation1
Binding sitei362homogentisateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciCAULO:CC2532-MONOMER
UniPathwayiUPA00139; UER00339

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:CC_2532
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002202471 – 425Homogentisate 1,2-dioxygenaseAdd BLAST425

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_2532

Structurei

3D structure databases

ProteinModelPortaliQ9A5B8
SMRiQ9A5B8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F1J Bacteria
COG3508 LUCA
HOGENOMiHOG000139824
KOiK00451
OMAiHGNYTPY

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00334 Homogentis_dioxygen, 1 hit
InterProiView protein in InterPro
IPR005708 Homogentis_dOase
IPR022950 Homogentis_dOase_bac
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR11056 PTHR11056, 1 hit
PfamiView protein in Pfam
PF04209 HgmA, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR01015 hmgA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A5B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRYQTGFG SYFETEAHPG ALPVGRNSPQ KVPFGLYAEQ LSGSAFTAPR
60 70 80 90 100
HENRRTWLYR LRPSAGHEAY QPYAQDKLVS AFPGPATPNR LRWSPLEIPA
110 120 130 140 150
APTDFVDGLV SLAGNADAAT LGGIAAHVYL VNVSMKNRVF YNADGEMLIV
160 170 180 190 200
PQMGELTLVT EMGVLKAGPG HIAVIPRGVR FRVEVEGPAR GYVCENYGAA
210 220 230 240 250
FRLPELGPIG ANGLANPRDF EAPVAAFEDI DTPTQVIQKF QGALWAATWD
260 270 280 290 300
HSPLDVVAWH GNLTPYRYDL SRFNTINTVS YDHPDPSIFT VLTSPSDTPG
310 320 330 340 350
TANCDFVIFP PRWMVAEDTF RPPWFHRNVM SEFMGLIHGA YDAKAGGFVP
360 370 380 390 400
GGASLHNCMS DHGPDVASHK KATEVVLAPH KIDGTMAFMF ESRWVFRPTH
410 420
LALESAALQS DYDACWTGFP KARLS
Length:425
Mass (Da):46,607
Last modified:June 1, 2001 - v1
Checksum:iB61AE29016AD9C27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK24503.1
PIRiC87563
RefSeqiNP_421335.1, NC_002696.2
WP_010920389.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK24503; AAK24503; CC_2532
GeneIDi943950
KEGGiccr:CC_2532
PATRICifig|190650.5.peg.2546

Similar proteinsi

Entry informationi

Entry nameiHGD_CAUVC
AccessioniPrimary (citable) accession number: Q9A5B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health