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Q9A5B8 (HGD_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

Short name=HGDO
EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:CC_2532
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity. HAMAP-Rule MF_00334

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Subunit structure

Hexamer; dimer of trimers By similarity. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_0000220247

Sites

Active site2831Proton acceptor By similarity
Metal binding3261Iron By similarity
Metal binding3321Iron By similarity
Metal binding3621Iron By similarity
Binding site3411homogentisate By similarity
Binding site3621homogentisate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9A5B8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: B61AE29016AD9C27

FASTA42546,607
        10         20         30         40         50         60 
MDLRYQTGFG SYFETEAHPG ALPVGRNSPQ KVPFGLYAEQ LSGSAFTAPR HENRRTWLYR 

        70         80         90        100        110        120 
LRPSAGHEAY QPYAQDKLVS AFPGPATPNR LRWSPLEIPA APTDFVDGLV SLAGNADAAT 

       130        140        150        160        170        180 
LGGIAAHVYL VNVSMKNRVF YNADGEMLIV PQMGELTLVT EMGVLKAGPG HIAVIPRGVR 

       190        200        210        220        230        240 
FRVEVEGPAR GYVCENYGAA FRLPELGPIG ANGLANPRDF EAPVAAFEDI DTPTQVIQKF 

       250        260        270        280        290        300 
QGALWAATWD HSPLDVVAWH GNLTPYRYDL SRFNTINTVS YDHPDPSIFT VLTSPSDTPG 

       310        320        330        340        350        360 
TANCDFVIFP PRWMVAEDTF RPPWFHRNVM SEFMGLIHGA YDAKAGGFVP GGASLHNCMS 

       370        380        390        400        410        420 
DHGPDVASHK KATEVVLAPH KIDGTMAFMF ESRWVFRPTH LALESAALQS DYDACWTGFP 


KARLS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK24503.1.
PIRC87563.
RefSeqNP_421335.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9A5B8.
SMRQ9A5B8. Positions 2-420.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK24503; AAK24503; CC_2532.
GeneID943950.
KEGGccr:CC_2532.
PATRIC21302090. VBICauCre124313_2546.

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMARCFYNSD.
OrthoDBEOG6D5FZK.

Enzyme and pathway databases

BioCycCAULO:CC2532-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_CAUCR
AccessionPrimary (citable) accession number: Q9A5B8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways