Reviewed, UniProtKB/Swiss-Prot Q9A5B8 (HGD_CAUCR)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	CC_2532

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_0000220247
Sites
	Metal binding	326	1	Iron By similarity
	Metal binding	332	1	Iron By similarity
	Metal binding	362	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9A5B8-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: B61AE29016AD9C27	FASTA	425	46,607
	10 20 30 40 50 60 MDLRYQTGFG SYFETEAHPG ALPVGRNSPQ KVPFGLYAEQ LSGSAFTAPR HENRRTWLYR 70 80 90 100 110 120 LRPSAGHEAY QPYAQDKLVS AFPGPATPNR LRWSPLEIPA APTDFVDGLV SLAGNADAAT 130 140 150 160 170 180 LGGIAAHVYL VNVSMKNRVF YNADGEMLIV PQMGELTLVT EMGVLKAGPG HIAVIPRGVR 190 200 210 220 230 240 FRVEVEGPAR GYVCENYGAA FRLPELGPIG ANGLANPRDF EAPVAAFEDI DTPTQVIQKF 250 260 270 280 290 300 QGALWAATWD HSPLDVVAWH GNLTPYRYDL SRFNTINTVS YDHPDPSIFT VLTSPSDTPG 310 320 330 340 350 360 TANCDFVIFP PRWMVAEDTF RPPWFHRNVM SEFMGLIHGA YDAKAGGFVP GGASLHNCMS 370 380 390 400 410 420 DHGPDVASHK KATEVVLAPH KIDGTMAFMF ESRWVFRPTH LALESAALQS DYDACWTGFP KARLS

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005673 Genomic DNA. Translation: AAK24503.1.
PIR	C87563.
RefSeq	NP_421335.1.
3D structure databases
HSSP	HSSP built from PDB template 1EYB based on UniProtKB Q93099.
ModBase	Search...
Genome annotation databases
GeneID	943950.
GenomeReviews	Gene locus CC_2532 in contig AE005673_GR.
KEGG	ccr:CC_2532.
NMPDR	fig|190650.1.peg.2515.
TIGR	CC_2532.
Phylogenomic databases
HOGENOM	Q9A5B8.
OMA	Q9A5B8. HRNCMSE.
Enzyme and pathway databases
BRENDA	1.13.11.5. 2191.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_CAUCR

Accession

Primary (citable) accession number: Q9A5B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	June 1, 2001
Last modified:	May 5, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)