Reviewed, UniProtKB/Swiss-Prot Q9A5B6 (HIS82_CAUCR)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	CC_2534

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000153343
Amino acid modifications
	Modified residue	240	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9A5B6-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 4ADC943593B7E5A8	FASTA	378	40,386
	10 20 30 40 50 60 MERGRMLVLD RKPLTPAWAS PMRQALEGVQ GYKAGMTLAE AARRTGLSAF SKLASNENLL 70 80 90 100 110 120 GPSPKVAEAV MAAMAEPHIY PDPHSDVLRA AIGARLGVSP ARVVVSPGSE ALIDYVFRAV 130 140 150 160 170 180 LHPGDSILLS SPTFPTYEIF GRCAEARIID VPRLANFDID VPAVCAAAAL GPKLLVLCTP 190 200 210 220 230 240 NNPTGNALKA ADFQAILAAT PRSTVVFVDE AYREYHEAFD TFAMLDAWGG PWVSARTFSK 250 260 270 280 290 300 AYGLAGLRMG YGVASSPELV DYLDRIRPPF NVTAVSQAAA LAAWEDQDYL KRTVDLTIAE 310 320 330 340 350 360 RGRVEAVLDD MGVEHTESHA NFVFLRSPAG PEATAAHLLH QGLIIRPTPV AGGWVRITIG 370 RPADNDALIA ALPAALSL

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK24505.1.
PIR	E87563.
RefSeq	NP_421337.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	943910.
GenomeReviews	Gene locus CC_2534 in contig AE005673_GR.
KEGG	ccr:CC_2534.
NMPDR	fig|190650.1.peg.2517.
TIGR	CC_2534.
Phylogenomic databases
HOGENOM	HBG646350.
OMA	SFPLHED.
Enzyme and pathway databases
BRENDA	2.6.1.9. 2191.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_CAUCR

Accession

Primary (citable) accession number: Q9A5B6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)