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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 19FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciCAULO:CC2598-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Synonyms:gid
Ordered Locus Names:CC_2598
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001172411 – 474Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST474

Proteomic databases

PRIDEiQ9A566

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_2598

Structurei

3D structure databases

ProteinModelPortaliQ9A566
SMRiQ9A566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI Bacteria
COG1206 LUCA
HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR020595 MnmG-rel_CS
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit
PROSITEiView protein in PROSITE
PS01281 GIDA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNSTYQPV HVIGGGLAGS EAAWQIAQSG VPVILHEMRK DDATGKVITD
60 70 80 90 100
AHQTDGLAEM VCSNSFRSDD WQFNAVGLLH AEMRKLGSLI MSCADQHQVP
110 120 130 140 150
AGGALAVDRD GFSTEVTKRL SQHPLVTIVR EEIAGLPPAP DGKNGWDNVI
160 170 180 190 200
VATGPLTSPA LAQAVLDLTG EGQLSFFDAI APIIHFESIN MDIAWRQSRY
210 220 230 240 250
DKEGPGGDAA AYINCPMNKE QYEAFIDALL AGPKSEFKEW ENVPYFDGCL
260 270 280 290 300
PIEVMAERGR ETLRHGPMKP VGLTNPRDPL VKAYAIVQLR QDNALGTLWN
310 320 330 340 350
MVGFQTKLKH GVQAETFRMI PGLEDAQFAR LGGLHRNTFI NSPKLLDKSL
360 370 380 390 400
RMKAQPRLRF AGQVTGVEGY VESAAMGLLT GRFAAADRKG APIDAPPPTT
410 420 430 440 450
ALGALVEHIT GGHLEAGNGP GSFQPMNINY GLLPPLEAPK VDEDGKKIPL
460 470
KERGRAKKRL MSLRALKDLD AWMA
Length:474
Mass (Da):51,368
Last modified:June 1, 2001 - v1
Checksum:iE0E12FDC7887FF1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK24567.1
PIRiC87571
RefSeqiNP_421399.1, NC_002696.2
WP_010920452.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK24567; AAK24567; CC_2598
GeneIDi943599
KEGGiccr:CC_2598
PATRICifig|190650.5.peg.2612

Entry informationi

Entry nameiTRMFO_CAUVC
AccessioniPrimary (citable) accession number: Q9A566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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