Reviewed, UniProtKB/Swiss-Prot Q9A3M3 (ADD_CAUCR)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	CC_3180

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Adenosine deaminase HAMAP MF_00540		PRO_0000194364
Sites
	Active site	204	1	Potential
	Active site	252	1	Potential
	Active site	285	1	Potential
	Active site	286	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9A3M3-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: DAA5ADE8D796E048	FASTA	344	37,193
	10 20 30 40 50 60 MTDASFAPSA SAEFVRGLPK AELHMHIEGS LEPELMFELA QRNGITLPFA SVEEIRAAYD 70 80 90 100 110 120 FSNLQDFLDI YYQGAGVLIT EADFKDLALA YFQRLAADGG AHAEIFFDPQ THTDRGIAFD 130 140 150 160 170 180 TVMNGLLAGM DEAEKTLGVT SKLILCFLRH LSEEAAFETL EQAKPWLAKL AGVGLDSSEV 190 200 210 220 230 240 GHPPAKFARV LQASRDLGLK VVAHAGEEGP PAYVWEAIDL VKVDRIDHGN RALEDEALTA 250 260 270 280 290 300 RLVKDGITLT VCPLSNLKLC GVPSLDVHPL KRMLDLGLKA TVNSDDPAYF GGYLLENYLA 310 320 330 340 TADAVGLTRD DIVTLAKNSF AGSFLTDAEK AQRIAAVEAY AAAH

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005673 Genomic DNA. Translation: AAK25142.1.
PIR	B87643.
RefSeq	NP_421974.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	943839.
GenomeReviews	Gene locus CC_3180 in contig AE005673_GR.
KEGG	ccr:CC_3180.
NMPDR	fig|190650.1.peg.3154.
TIGR	CC_3180.
Phylogenomic databases
HOGENOM	Q9A3M3.
OMA	LAQNSLD.
Enzyme and pathway databases
BRENDA	3.5.4.4. 2191.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_CAUCR

Accession

Primary (citable) accession number: Q9A3M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)