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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15MagnesiumUniRule annotation1
Metal bindingi75MagnesiumUniRule annotation1
Metal bindingi147MagnesiumUniRule annotation1
Metal bindingi150MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
Biological processDNA damage, DNA recombination, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCAULO:CC3238-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotation
Ordered Locus Names:CC_3238
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830851 – 169Crossover junction endodeoxyribonuclease RuvCAdd BLAST169

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_3238

Structurei

3D structure databases

ProteinModelPortaliQ9A3G6
SMRiQ9A3G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105NHU Bacteria
COG0817 LUCA
HOGENOMiHOG000012181
KOiK01159
OMAiGLTRCGI

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR020563 X-over_junc_endoDNase_Mg_BS
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit
PROSITEiView protein in PROSITE
PS01321 RUVC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A3G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNANRLPTR ILGLDPGLRR TGWGVLAVEG SRMTHIAHGV ITPDEKAEFA
60 70 80 90 100
DRLLHLFEGI TAVIEQHRPD EAAVEEVFLN TNAQSTLKLG HARAAALIAP
110 120 130 140 150
ARAGLLVAEY STRLVKKAVV GTGAADKAQI GFMIARLLPT AGKTTADCAD
160
ALAVAITHAN LRVANRRVA
Length:169
Mass (Da):17,960
Last modified:June 1, 2001 - v1
Checksum:i2909262CCC865470
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK25200.1
PIRiD87650
RefSeqiNP_422032.1, NC_002696.2
WP_010921071.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK25200; AAK25200; CC_3238
GeneIDi943824
KEGGiccr:CC_3238
PATRICifig|190650.5.peg.3244

Similar proteinsi

Entry informationi

Entry nameiRUVC_CAUVC
AccessioniPrimary (citable) accession number: Q9A3G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health