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Q9A3G6 (RUVC_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:CC_3238
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 169169Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_0000183085

Sites

Metal binding151Magnesium By similarity
Metal binding751Magnesium By similarity
Metal binding1471Magnesium By similarity
Metal binding1501Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9A3G6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 2909262CCC865470

FASTA16917,960
        10         20         30         40         50         60 
MMNANRLPTR ILGLDPGLRR TGWGVLAVEG SRMTHIAHGV ITPDEKAEFA DRLLHLFEGI 

        70         80         90        100        110        120 
TAVIEQHRPD EAAVEEVFLN TNAQSTLKLG HARAAALIAP ARAGLLVAEY STRLVKKAVV 

       130        140        150        160 
GTGAADKAQI GFMIARLLPT AGKTTADCAD ALAVAITHAN LRVANRRVA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK25200.1.
PIRD87650.
RefSeqNP_422032.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9A3G6.
SMRQ9A3G6. Positions 11-161.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK25200; AAK25200; CC_3238.
GeneID943824.
KEGGccr:CC_3238.
PATRIC21303504. VBICauCre124313_3244.

Phylogenomic databases

eggNOGCOG0817.
HOGENOMHOG000012181.
KOK01159.
OMARQVQEMV.
OrthoDBEOG6RG044.

Enzyme and pathway databases

BioCycCAULO:CC3238-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
PROSITEPS01321. RUVC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRUVC_CAUCR
AccessionPrimary (citable) accession number: Q9A3G6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families