Reviewed, UniProtKB/Swiss-Prot Q9A3G2 (PUR72_CAUCR)

Names and origin

Protein names

Recommended name:
    Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase 2

Gene names

Name:	purC2
Ordered Locus Names:	CC_3242

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2 HAMAP MF_00137		PRO_0000100814

Sequences

	Sequence		Length	Mass (Da)
	Q9A3G2-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 9DDF4098C98AB4C3	FASTA	320	34,930
	10 20 30 40 50 60 MTLSAPNALA VVDLPCLPNH YRGKVRDNYD LPDGRRVIVA SDRLSAFDRN LCAVPGKGQV 70 80 90 100 110 120 LTETARFWFD ATADICPNHV VAYPDPNVLI GKRLKMLPVE LVVRGYLAGT TSTSILTLYN 130 140 150 160 170 180 KGERQMYGVT LPDGLKANQR LPQAILTPTS KAADGDHDAP LSPDEVLAQG LVTPAQWEQL 190 200 210 220 230 240 SAYALALFAR GQAMAAERGL ILADTKYEFG LDETGAIVLA DEIHTPDSSR FWKAATYEAR 250 260 270 280 290 300 FEAGQRPESF DKDFVRAWVA ERCDPYNDSI PEIPAELIAQ ASAVYIEAFE AITGQTFAAP 310 320 DASEPVMARV KRNLDAYLAG

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005673 Genomic DNA. Translation: AAK25204.1.
PIR	H87650.
RefSeq	NP_422036.1.
3D structure databases
HSSP	HSSP built from PDB template 1A48 based on UniProtKB P27616.
ModBase	Search...
Genome annotation databases
GeneID	940952.
GenomeReviews	Gene locus CC_3242 in contig AE005673_GR.
KEGG	ccr:CC_3242.
NMPDR	fig|190650.1.peg.3216.
TIGR	CC_3242.
Phylogenomic databases
HOGENOM	Q9A3G2.
OMA	LTLMDEV.
Enzyme and pathway databases
BRENDA	6.3.2.6. 2191.
Family and domain databases
HAMAP	MF_00137. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
ProDom	PD003043. SAICAR_synt. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR72_CAUCR

Accession

Primary (citable) accession number: Q9A3G2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)