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Q9A354

- GCSPB_CAUCR

UniProt

Q9A354 - GCSPB_CAUCR

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:CC_3352
    OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
    Taxonomic identifieri190650 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167002Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei296 – 2961N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ9A354.
    SMRiQ9A354. Positions 35-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiWTGLMMI.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9A354-1 [UniParc]FASTAAdd to Basket

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    MNNVGRPTRP EAANDAANGH ETLTGARGLL QDEALIFELD GWNKTGVDLP    50
    PVTAAPSSDL NGLLRDAPIG LPGLSEPETV RHYVRLSQKN HAIDLALYPL 100
    GSCTMKHNPR LNEKMARLPG FSDIHPLQPQ STVQGALELM DRLAHWLKTL 150
    TGMPAVALTP KAGAHGELCG LLAIRAAHEA AGNGHRKTVL APTSAHGTNP 200
    ATAAFVGYTV VEIAQTEDGR VDLADLESKL GDHVAAIMVT NPNTCGLFER 250
    DVVEIARLTH AAGAYFYCDG ANFNAIVGRV RPGDLGVDAM HINLHKTFST 300
    PHGGGGPGAG PVVLSEALAP FAPTPWLTHG DNGFELAEHA GDDDAKTAFG 350
    RMSAFHGQMG MYVRAYAYML SHGADGLRQV AEDAVLNANY IKAQLKDVMS 400
    PAFPEGPCMH EALFDDSWLE GTGVTTLDFA KAMIDEGFHP MTMYFPLVVH 450
    GAMLIEPTET ESKHELDRFI AALRALAGAA KAGDTERFKG APFHAPLRRL 500
    DETQAARKPR LRWKPVAAAP LAAE 524
    Length:524
    Mass (Da):55,993
    Last modified:June 1, 2001 - v1
    Checksum:i58ACACEBDF631A3B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK25314.1.
    PIRiF87664.
    RefSeqiNP_422146.1. NC_002696.2.
    WP_010921181.1. NC_002696.2.

    Genome annotation databases

    EnsemblBacteriaiAAK25314; AAK25314; CC_3352.
    GeneIDi940866.
    KEGGiccr:CC_3352.
    PATRICi21303732. VBICauCre124313_3358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK25314.1 .
    PIRi F87664.
    RefSeqi NP_422146.1. NC_002696.2.
    WP_010921181.1. NC_002696.2.

    3D structure databases

    ProteinModelPortali Q9A354.
    SMRi Q9A354. Positions 35-513.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK25314 ; AAK25314 ; CC_3352 .
    GeneIDi 940866.
    KEGGi ccr:CC_3352.
    PATRICi 21303732. VBICauCre124313_3358.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi WTGLMMI.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19089 / CB15.

    Entry informationi

    Entry nameiGCSPB_CAUCR
    AccessioniPrimary (citable) accession number: Q9A354
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3