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Q9A354

- GCSPB_CAUCR

UniProt

Q9A354 - GCSPB_CAUCR

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:CC_3352
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei296 – 2961N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9A354.
SMRiQ9A354. Positions 35-513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR000192. Aminotrans_V_dom.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9A354-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNVGRPTRP EAANDAANGH ETLTGARGLL QDEALIFELD GWNKTGVDLP
60 70 80 90 100
PVTAAPSSDL NGLLRDAPIG LPGLSEPETV RHYVRLSQKN HAIDLALYPL
110 120 130 140 150
GSCTMKHNPR LNEKMARLPG FSDIHPLQPQ STVQGALELM DRLAHWLKTL
160 170 180 190 200
TGMPAVALTP KAGAHGELCG LLAIRAAHEA AGNGHRKTVL APTSAHGTNP
210 220 230 240 250
ATAAFVGYTV VEIAQTEDGR VDLADLESKL GDHVAAIMVT NPNTCGLFER
260 270 280 290 300
DVVEIARLTH AAGAYFYCDG ANFNAIVGRV RPGDLGVDAM HINLHKTFST
310 320 330 340 350
PHGGGGPGAG PVVLSEALAP FAPTPWLTHG DNGFELAEHA GDDDAKTAFG
360 370 380 390 400
RMSAFHGQMG MYVRAYAYML SHGADGLRQV AEDAVLNANY IKAQLKDVMS
410 420 430 440 450
PAFPEGPCMH EALFDDSWLE GTGVTTLDFA KAMIDEGFHP MTMYFPLVVH
460 470 480 490 500
GAMLIEPTET ESKHELDRFI AALRALAGAA KAGDTERFKG APFHAPLRRL
510 520
DETQAARKPR LRWKPVAAAP LAAE
Length:524
Mass (Da):55,993
Last modified:June 1, 2001 - v1
Checksum:i58ACACEBDF631A3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005673 Genomic DNA. Translation: AAK25314.1.
PIRiF87664.
RefSeqiNP_422146.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK25314; AAK25314; CC_3352.
GeneIDi940866.
KEGGiccr:CC_3352.
PATRICi21303732. VBICauCre124313_3358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005673 Genomic DNA. Translation: AAK25314.1 .
PIRi F87664.
RefSeqi NP_422146.1. NC_002696.2.

3D structure databases

ProteinModelPortali Q9A354.
SMRi Q9A354. Positions 35-513.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK25314 ; AAK25314 ; CC_3352 .
GeneIDi 940866.
KEGGi ccr:CC_3352.
PATRICi 21303732. VBICauCre124313_3358.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR000192. Aminotrans_V_dom.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiGCSPB_CAUCR
AccessioniPrimary (citable) accession number: Q9A354
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3