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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:CC_3352
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001670021 – 524Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei296N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ9A354

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_3352

Structurei

3D structure databases

ProteinModelPortaliQ9A354
SMRiQ9A354
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A354-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNVGRPTRP EAANDAANGH ETLTGARGLL QDEALIFELD GWNKTGVDLP
60 70 80 90 100
PVTAAPSSDL NGLLRDAPIG LPGLSEPETV RHYVRLSQKN HAIDLALYPL
110 120 130 140 150
GSCTMKHNPR LNEKMARLPG FSDIHPLQPQ STVQGALELM DRLAHWLKTL
160 170 180 190 200
TGMPAVALTP KAGAHGELCG LLAIRAAHEA AGNGHRKTVL APTSAHGTNP
210 220 230 240 250
ATAAFVGYTV VEIAQTEDGR VDLADLESKL GDHVAAIMVT NPNTCGLFER
260 270 280 290 300
DVVEIARLTH AAGAYFYCDG ANFNAIVGRV RPGDLGVDAM HINLHKTFST
310 320 330 340 350
PHGGGGPGAG PVVLSEALAP FAPTPWLTHG DNGFELAEHA GDDDAKTAFG
360 370 380 390 400
RMSAFHGQMG MYVRAYAYML SHGADGLRQV AEDAVLNANY IKAQLKDVMS
410 420 430 440 450
PAFPEGPCMH EALFDDSWLE GTGVTTLDFA KAMIDEGFHP MTMYFPLVVH
460 470 480 490 500
GAMLIEPTET ESKHELDRFI AALRALAGAA KAGDTERFKG APFHAPLRRL
510 520
DETQAARKPR LRWKPVAAAP LAAE
Length:524
Mass (Da):55,993
Last modified:June 1, 2001 - v1
Checksum:i58ACACEBDF631A3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK25314.1
PIRiF87664
RefSeqiNP_422146.1, NC_002696.2
WP_010921181.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK25314; AAK25314; CC_3352
GeneIDi940866
KEGGiccr:CC_3352
PATRICifig|190650.5.peg.3358

Similar proteinsi

Entry informationi

Entry nameiGCSPB_CAUVC
AccessioniPrimary (citable) accession number: Q9A354
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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