Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9A354 (GCSPB_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Ordered Locus Names:CC_3352
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_0000167002

Amino acid modifications

Modified residue2961N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9A354 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 58ACACEBDF631A3B

FASTA52455,993
        10         20         30         40         50         60 
MNNVGRPTRP EAANDAANGH ETLTGARGLL QDEALIFELD GWNKTGVDLP PVTAAPSSDL 

        70         80         90        100        110        120 
NGLLRDAPIG LPGLSEPETV RHYVRLSQKN HAIDLALYPL GSCTMKHNPR LNEKMARLPG 

       130        140        150        160        170        180 
FSDIHPLQPQ STVQGALELM DRLAHWLKTL TGMPAVALTP KAGAHGELCG LLAIRAAHEA 

       190        200        210        220        230        240 
AGNGHRKTVL APTSAHGTNP ATAAFVGYTV VEIAQTEDGR VDLADLESKL GDHVAAIMVT 

       250        260        270        280        290        300 
NPNTCGLFER DVVEIARLTH AAGAYFYCDG ANFNAIVGRV RPGDLGVDAM HINLHKTFST 

       310        320        330        340        350        360 
PHGGGGPGAG PVVLSEALAP FAPTPWLTHG DNGFELAEHA GDDDAKTAFG RMSAFHGQMG 

       370        380        390        400        410        420 
MYVRAYAYML SHGADGLRQV AEDAVLNANY IKAQLKDVMS PAFPEGPCMH EALFDDSWLE 

       430        440        450        460        470        480 
GTGVTTLDFA KAMIDEGFHP MTMYFPLVVH GAMLIEPTET ESKHELDRFI AALRALAGAA 

       490        500        510        520 
KAGDTERFKG APFHAPLRRL DETQAARKPR LRWKPVAAAP LAAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK25314.1.
PIRF87664.
RefSeqNP_422146.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9A354.
SMRQ9A354. Positions 35-513.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK25314; AAK25314; CC_3352.
GeneID940866.
KEGGccr:CC_3352.
PATRIC21303732. VBICauCre124313_3358.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239368.
KOK00283.
OMAMHINLHK.
OrthoDBEOG6HMXDX.
ProtClustDBPRK04366.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_CAUCR
AccessionPrimary (citable) accession number: Q9A354
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families