Reviewed, UniProtKB/Swiss-Prot Q9A353 (GCSPA_CAUCR)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	CC_3353

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_0000166962

Sequences

	Sequence		Length	Mass (Da)
	Q9A353-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D62740DA0E84303F	FASTA	448	47,298
	10 20 30 40 50 60 MRYLPLTPED RVEMLGAIGV KSIDDLFVDV PVSARRDAPV DLPHHAGELD VEREMAGLAR 70 80 90 100 110 120 RNRAAGEGPF FCGAGAYRHH VPATVDHIIQ RSEFLTSYTP YQPEIAQGTL QVLFEFQTQV 130 140 150 160 170 180 AALTGMEVAN ASLYDGSTGA AEAVMMAQRV TRRNKAVMSG GVHPHYVGAI ETLAHAAGVA 190 200 210 220 230 240 TQALPAAVDA EDAVIAAIDQ DTACVVVQTP NVFGTVTDVS KIAEAAHAAG ALLIVVTTEA 250 260 270 280 290 300 VSFGLLKSPG EMGADIAVAE GQSIGNGLNF GGPYVGLFAC KEKFVRQMPG RLCGETVDAD 310 320 330 340 350 360 GKRGFVLTLS TREQHIRRDK ATSNICTNSG LCALAFSIHM SLLGETGLRQ LAAVNHQKAL 370 380 390 400 410 420 ALRDALKAVP GVEILTPRFF NEFAIRVPGK AAEVVEILAA HGVIAGVPFS RLDAKAGLDD 430 440 VLLVAATETT LDIDIPVFAK ALTKVFAQ

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005673 Genomic DNA. Translation: AAK25315.1.
PIR	G87664.
RefSeq	NP_422147.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	943794.
GenomeReviews	Gene locus CC_3353 in contig AE005673_GR.
KEGG	ccr:CC_3353.
NMPDR	fig|190650.1.peg.3327.
TIGR	CC_3353.
Phylogenomic databases
HOGENOM	Q9A353.
OMA	Q9A353. VANASMY.
Enzyme and pathway databases
BRENDA	1.4.4.2. 2191.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_CAUCR

Accession

Primary (citable) accession number: Q9A353

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)