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Q9A353 (GCSPA_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1
EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:CC_3353
OrganismCaulobacter crescentus (Caulobacter vibrioides)
Taxonomic identifier155892 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP MF_00712

Catalytic activity

Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712
PRO_0000166962

Sequences

Sequence LengthMass (Da)Tools
Q9A353 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D62740DA0E84303F

FASTA44847,298
        10         20         30         40         50         60 
MRYLPLTPED RVEMLGAIGV KSIDDLFVDV PVSARRDAPV DLPHHAGELD VEREMAGLAR 

        70         80         90        100        110        120 
RNRAAGEGPF FCGAGAYRHH VPATVDHIIQ RSEFLTSYTP YQPEIAQGTL QVLFEFQTQV 

       130        140        150        160        170        180 
AALTGMEVAN ASLYDGSTGA AEAVMMAQRV TRRNKAVMSG GVHPHYVGAI ETLAHAAGVA 

       190        200        210        220        230        240 
TQALPAAVDA EDAVIAAIDQ DTACVVVQTP NVFGTVTDVS KIAEAAHAAG ALLIVVTTEA 

       250        260        270        280        290        300 
VSFGLLKSPG EMGADIAVAE GQSIGNGLNF GGPYVGLFAC KEKFVRQMPG RLCGETVDAD 

       310        320        330        340        350        360 
GKRGFVLTLS TREQHIRRDK ATSNICTNSG LCALAFSIHM SLLGETGLRQ LAAVNHQKAL 

       370        380        390        400        410        420 
ALRDALKAVP GVEILTPRFF NEFAIRVPGK AAEVVEILAA HGVIAGVPFS RLDAKAGLDD 

       430        440 
VLLVAATETT LDIDIPVFAK ALTKVFAQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005673 Genomic DNA. Translation: AAK25315.1.
PIRG87664.
RefSeqNP_422147.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9A353.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID943794.
GenomeReviewsGene locus CC_3353 in contig AE005673_GR.
KEGGccr:CC_3353.
NMPDRfig|190650.1.peg.3327.
PATRIC21303734. VBICauCre124313_3359.
TIGRCC_3353.

Phylogenomic databases

HOGENOMHBG288345.
OMAVANASMY.
ProtClustDBPRK00451.

Family and domain databases

HAMAPMF_00712. GcvPA.
[Tree]
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KOK00282.
PANTHERPTHR11773. GDC-P. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_CAUCR
AccessionPrimary (citable) accession number: Q9A353
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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