Reviewed, UniProtKB/Swiss-Prot Q9A342 (KHSE_CAUCR)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	CC_3364

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Homoserine kinase HAMAP MF_00301		PRO_0000172189

Sequences

	Sequence		Length	Mass (Da)
	Q9A342-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 97C9304EB6508C8A	FASTA	317	35,025
	10 20 30 40 50 60 MAVYTDITDQ ELEAFLEGYD LGAPLAFKGI AEGVENSNFL LETEKGRYIL TVYERRVKAE 70 80 90 100 110 120 DLPYFLNMLT WLADRGYPSA RPIPTRSGAT LSSLRGKPAA IVEFLPGLSV RKPTAAHCRE 130 140 150 160 170 180 AGEGLAWLHL AGEGYPGRRA NDLGQAAWSP LFSKHRKAAE DLKPGLSATI DNDLAQLSLM 190 200 210 220 230 240 WPRNLPTGTI HADYFPDNVF FQSNGKFAAA IDFYFACDDA YAYDVAVTLN AWCFEADGSF 250 260 270 280 290 300 NITAAKALLN GYERRRPLSP IEKEALPILA RGAAMRFFLT RLADWGSTPA GALVRPKDPL 310 EYERKLAVHR EGLVLFA

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005673 Genomic DNA. Translation: AAK25326.1.
PIR	B87666.
RefSeq	NP_422158.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	943796.
GenomeReviews	Gene locus CC_3364 in contig AE005673_GR.
KEGG	ccr:CC_3364.
NMPDR	fig|190650.1.peg.3338.
TIGR	CC_3364.
Phylogenomic databases
HOGENOM	Q9A342.
OMA	ADLFRDN.
Enzyme and pathway databases
BRENDA	2.7.1.39. 2191.
Family and domain databases
HAMAP	MF_00301. [Tree]
InterPro	IPR002575. APH_trans. IPR005280. Homoserine_Kinase_ThrB. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
TIGRFAMs	TIGR00938. thrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_CAUCR

Accession

Primary (citable) accession number: Q9A342

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)