Q9A2L1 (DAPB_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	CC_3550

Organism

Caulobacter crescentus (Caulobacter vibrioides)

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000141425

Sequences

	Sequence		Length	Mass (Da)
	Q9A2L1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: B8AD3BB269A47AE4	FASTA	257	26,425
	10 20 30 40 50 60 MSQPVKIAIA GANGRMGRAV AQALEGRSDA VVAARFERPG DAGEGLVARE TALAAAEAVI 70 80 90 100 110 120 DFTLPEASVA LAEEAAANGG PALVIGSTGF SDEQLDRIDA AATKIVIVRS GNYSLGVNML 130 140 150 160 170 180 MGLVRQAAAA LPAQDWDIEV FEAHHKRKID APSGTALMLG EAAAEGRGIN LAKVSDRGRD 190 200 210 220 230 240 GVTGPRKDGD IGFSVVRGGG IIGEHSVIFA GESESLTLSH SAIDRGLFAR GAIAAAVWVK 250 GKPPGLYDMQ DVLGFKK

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK25512.1.
PIR	D87689.
RefSeq	NP_422344.1. NC_002696.2.
3D structure databases
ProteinModelPortal	Q9A2L1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	943731.
GenomeReviews	Gene locus CC_3550 in contig AE005673_GR.
KEGG	ccr:CC_3550.
NMPDR	fig|190650.1.peg.3524.
PATRIC	21304134. VBICauCre124313_3553.
TIGR	CC_3550.
Phylogenomic databases
HOGENOM	HBG594002.
OMA	MVRVILN.
ProtClustDB	PRK00048.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_CAUCR

Accession

Primary (citable) accession number: Q9A2L1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program