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Q9A2I0 (ACSA_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene names
Name:acsA
Ordered Locus Names:CC_3581
OrganismCaulobacter crescentus (Caulobacter vibrioides)
Taxonomic identifier155892 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length647 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionAMP binding

Inferred from electronic annotation. Source: InterPro

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 647647Acetyl-coenzyme A synthetase HAMAP MF_01123
PRO_0000208359

Sites

Active site5161 By similarity

Amino acid modifications

Modified residue6081N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9A2I0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0CA366B8F48048EF

FASTA64770,836
        10         20         30         40         50         60 
MVSDGQVFPV PADLARDAHI DAAAYDAALA RVEADPEGYW RDIAARLDWI TPPTKIKDVS 

        70         80         90        100        110        120 
YAKEDFRIRW YEDGVLNVSA NCIDRHLPAK KDDVALVFEG DEPGTSSTLT YGQLHEEVCR 

       130        140        150        160        170        180 
MANVLKAQGV KKGDRVTIYL PMVPLAAVAM LACARIGAVH SVVFGGFSPD SIAGRIQDCA 

       190        200        210        220        230        240 
SHFVITADEG RRGGRRVPLK ANIDEALKHC PWVGKVLMIR WTGADVPLKA GRDIVWQDVR 

       250        260        270        280        290        300 
DTVSADCPPE PMNAEDPLFI LYTSGSTGKP KGVLHTTGGY LAWASWTFWA VFDYKPGEVF 

       310        320        330        340        350        360 
WCTADVGWVT GHSYVVYGPL ANGGTSLIFE GVPNYPTPSR FWEVIDKHQV SIFYTAPTAL 

       370        380        390        400        410        420 
RALMREGDAH VTKNDLSSLR LLGSVGEPIN PEAWLWYHRV VGKEKLPIVD TWWQTETGGM 

       430        440        450        460        470        480 
LITPLPGATA LKPGSASKPL PGVKPQLVDA EGKFLDGATE GNLVITDSWP GQMRTVYGDH 

       490        500        510        520        530        540 
QRFFETYFST YPGKYFTGDG CRRDADGYYW ITGRVDDVIN VSGHRLGTAE IESALVAHET 

       550        560        570        580        590        600 
VAEAAVVGYP HDIKGQGVYA YVTLKAGIEA TDALRKDLVL WVRHEIGPFA APDVIQWAPG 

       610        620        630        640 
LPKTRSGKIM RRILRKIAEN ELGSLGDTST LADPSVVDDL VKNRAGT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005673 Genomic DNA. Translation: AAK25543.1.
PIRC87693.
RefSeqNP_422375.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9A2I0.
SMRQ9A2I0. Positions 10-644.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID942891.
GenomeReviewsGene locus CC_3581 in contig AE005673_GR.
KEGGccr:CC_3581.
NMPDRfig|190650.1.peg.3555.
PATRIC21304198. VBICauCre124313_3585.
TIGRCC_3581.

Phylogenomic databases

HOGENOMHBG547964.
OMAIARTIWG.
ProtClustDBPRK00174.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACSA_CAUCR
AccessionPrimary (citable) accession number: Q9A2I0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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