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Protein

Formyltetrahydrofolate deformylase

Gene

purU

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formyltetrahydrofolate deformylase (purU)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei223UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

One-carbon metabolismUniRule annotation, Purine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00170.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyltetrahydrofolate deformylaseUniRule annotation (EC:3.5.1.10UniRule annotation)
Alternative name(s):
Formyl-FH(4) hydrolaseUniRule annotation
Gene namesi
Name:purUUniRule annotation
Ordered Locus Names:CC_3630Imported
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)Imported
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_3630.

Structurei

3D structure databases

ProteinModelPortaliQ9A2D5.
SMRiQ9A2D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 80ACTInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the PurU family.UniRule annotation
Contains 1 ACT domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CIY. Bacteria.
COG0788. LUCA.
HOGENOMiHOG000033576.
KOiK01433.
OMAiFMRTELT.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
HAMAPiMF_01927. PurU. 1 hit.
InterProiIPR002912. ACT_dom.
IPR002376. Formyl_transf_N.
IPR004810. PurU.
[Graphical view]
PANTHERiPTHR10520:SF7. PTHR10520:SF7. 1 hit.
PfamiPF01842. ACT. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
PRINTSiPR01575. FFH4HYDRLASE.
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00655. PurU. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9A2D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILTLSCPDQ RGIVAKVSAF LFERGCNILD AQQFDDQETG QFFMRVVFDA
60 70 80 90 100
DGADREALRG DFGALADGFK MKWTLRNRAD RYRVLLLASK FDHCLADLVY
110 120 130 140 150
RWRIGELPMD ITGVVSNHPA QTYAHVDLSG LDFHHLPVTK ETKFEQEAEL
160 170 180 190 200
WKLIQETKTD IVVLARYMQV LSDGLSAKLQ GRCINIHHSF LPGFKGAKPY
210 220 230 240 250
HQAHARGVKL IGASAHYVTG DLDEGPIIEQ DVERISHRDT PEDLVRKGRD
260 270 280
IERRVLARAL RYRLEDRVLL NGRKTVVFTD
Length:280
Mass (Da):31,889
Last modified:June 1, 2001 - v1
Checksum:i64F1DB6DEF842C14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK25592.1.
PIRiD87699.
RefSeqiNP_422424.1. NC_002696.2.
WP_010921457.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK25592; AAK25592; CC_3630.
GeneIDi942876.
KEGGiccr:CC_3630.
PATRICi21304298. VBICauCre124313_3632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK25592.1.
PIRiD87699.
RefSeqiNP_422424.1. NC_002696.2.
WP_010921457.1. NC_002696.2.

3D structure databases

ProteinModelPortaliQ9A2D5.
SMRiQ9A2D5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_3630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK25592; AAK25592; CC_3630.
GeneIDi942876.
KEGGiccr:CC_3630.
PATRICi21304298. VBICauCre124313_3632.

Phylogenomic databases

eggNOGiENOG4105CIY. Bacteria.
COG0788. LUCA.
HOGENOMiHOG000033576.
KOiK01433.
OMAiFMRTELT.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00170.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
HAMAPiMF_01927. PurU. 1 hit.
InterProiIPR002912. ACT_dom.
IPR002376. Formyl_transf_N.
IPR004810. PurU.
[Graphical view]
PANTHERiPTHR10520:SF7. PTHR10520:SF7. 1 hit.
PfamiPF01842. ACT. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
PRINTSiPR01575. FFH4HYDRLASE.
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00655. PurU. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9A2D5_CAUCR
AccessioniPrimary (citable) accession number: Q9A2D5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.