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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei626ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAULO:CC3749-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CC_3749
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001519951 – 861Leucine--tRNA ligaseAdd BLAST861

Proteomic databases

PRIDEiQ9A217

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_3749

Structurei

3D structure databases

ProteinModelPortaliQ9A217
SMRiQ9A217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi623 – 627"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYNPKDTE PKWREAWAKA DVFKTGEIND GRPKYYVLEM FPYPSGRIHM
60 70 80 90 100
GHVRNYAMGD VVARYKRAQG FNVLHPMGWD AFGMPAENAA MERGVHPKGW
110 120 130 140 150
TYDNIAAMRE QLKSLGISVD WSREFATCDP EYYGKQQAWF LRLLKRGLVY
160 170 180 190 200
RKEASVNWDP VDMTVLANEQ VIDGKGWRSG AVVEKRKLTQ WFLRITDYAD
210 220 230 240 250
ALIDGLKTLD RWPDKVRLMQ ENWIGRSKGL RFKFQFDGEA PDGMAEGLEV
260 270 280 290 300
YTTRPDTLFG ASFVGIAPEH PLAEQLAAAN PQIQTFIADC RKGGTSEAEI
310 320 330 340 350
ESAEKLGYDT GLRVKHPLDP SITLPVWIAN FILMDYGTGA IFACPAHDQR
360 370 380 390 400
DLDFARKYDL PVLPVVLPNG EDPATFTVGK EAYVGPGKIF NSKFLDGLDV
410 420 430 440 450
EAAKAEAIAR IEAANQGQGA TVYRLRDWGV SRQRYWGCPI PVIHCEACGV
460 470 480 490 500
VPVPEDQLPV ALPDDVTFDK PGNPLLRHPT WRHTTCPSCG GKAERETDTL
510 520 530 540 550
DTFIDSSWYF ARFADTQAAE PVGKDAADHW LPVDQYIGGV EHAILHLLYA
560 570 580 590 600
RFITRALKDE GLLSVEEPFA GLFTQGMVTH EAYKNEAGEW VEPSDVVITT
610 620 630 640 650
EGSTRTAKHA KTGAPIIIGD IEKMSKSKKN VVAPEDIFEA YGVDSARLFV
660 670 680 690 700
MSDSPPERDV QWTNSGVEGS WRFTHRLWNE FDSQPAGDFA HDDSDEAALA
710 720 730 740 750
LRKAAHKLIG FVTDSIEGFR FNSGVARLYE FLNALKAAPA EGASQAVLAA
760 770 780 790 800
RAEALNILAR LVAPFTPHLA EEAWARMGGE GMVVDAPWPK ADPALAADDE
810 820 830 840 850
RVLPIQINGK RRGEIKVKAG APDDEVTKIA LADPNVMAHL EGLTVRKVIV
860
VKDRIVNIVA N
Length:861
Mass (Da):95,536
Last modified:June 1, 2001 - v1
Checksum:iC546C7C0BD7DB374
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK25711.1
PIRiC87714
RefSeqiNP_422543.1, NC_002696.2
WP_010921576.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK25711; AAK25711; CC_3749
GeneIDi940606
KEGGiccr:CC_3749
PATRICifig|190650.5.peg.3751

Similar proteinsi

Entry informationi

Entry nameiSYL_CAUVC
AccessioniPrimary (citable) accession number: Q9A217
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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