Q9A1S9 (Q9A1S9_STRP1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative pyrroline carboxylate reductase EMBL AAK33229.1
EC=1.5.1.2 EMBL AAK33229.1

Submitted name:
Pyrroline-5-carboxylate reductase EMBL AAZ50715.1
EC=1.5.1.2 EMBL AAZ50715.1

Gene names

Name:	proC EMBL AAK33229.1
Ordered Locus Names:	M5005_Spy0096, SPy_0112

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

301447 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	NADP PDB 2AHR Nucleotide-binding PDB 2AHR
Molecular function	Oxidoreductase EMBL AAK33229.1
Technical term	3D-structure PDB 2AHR PDB 2AMF Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	10 – 11	2	NADP PDB 2AHR
	Nucleotide binding	65 – 67	3	NADP PDB 2AHR
	Nucleotide binding	219 – 221	3	NADP PDB 2AHR
Sites
	Binding site	31	1	NADP PDB 2AHR
	Binding site	35	1	NADP PDB 2AHR
	Binding site	51	1	NADP PDB 2AHR
	Binding site	88	1	NADP; via amide nitrogen PDB 2AHR

Sequences

	Sequence		Length	Mass (Da)
	Q9A1S9 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 9EF15B4BD6021033	FASTA	256	27,306
	10 20 30 40 50 60 MKIGIIGVGK MASAIIKGLK QTPHELIISG SSLERSKEIA EQLALPYAMS HQDLIDQVDL 70 80 90 100 110 120 VILGIKPQLF ETVLKPLHFK QPIISMAAGI SLQRLATFVG QDLPLLRIMP NMNAQILQSS 130 140 150 160 170 180 TALTGNALVS QELQARVRDL TDSFGSTFDI SEKDFDTFTA LAGSSPAYIY LFIEALAKAG 190 200 210 220 230 240 VKNGIPKAKA LEIVTQTVLA SASNLKTSSQ SPHDFIDAIC SPGGTTIAGL MELERLGLTA 250 TVSSAIDKTI DKAKSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed: 11296296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.
[2]	"Crystal structures of delta1-pyrroline-5-carboxylate reductase from human pathogens Neisseria meningitides and Streptococcus pyogenes." Nocek B., Chang C., Li H., Lezondra L., Holzle D., Collart F., Joachimiak A. J. Mol. Biol. 354:91-106(2005) [PubMed: 16233902] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH NADP.
[3]	"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed: 16088826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE004092 Genomic DNA. Translation: AAK33229.1.
CP000017 Genomic DNA. Translation: AAZ50715.1.

RefSeq

NP_268508.1. NC_002737.1.
YP_281460.1. NC_007297.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2AHR	X-ray	2.15	A/B/C/D/E	1-256	[»]
2AMF	X-ray	2.20	A/B/C/D/E	1-256	[»]

ProteinModelPortal

Q9A1S9.

SMR

Q9A1S9. Positions 1-256.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBSTRT00000000957; EBSTRP00000000957; EBSTRG00000000957.
EBSTRT00000027504; EBSTRP00000026522; EBSTRG00000027504.

GeneID

3572836.
900451.

GenomeReviews

Gene locus M5005_Spy0096 in contig AE004092_GR.
Gene locus proC in contig CP000017_GR.

PATRIC

19714041. VBIStrPyo79812_0096.

Organism-specific databases

CMR

Search...

Phylogenomic databases

GeneTree

EBGT00050000027129.

HOGENOM

HBG726602.

OMA

RTFNEHQ.

ProtClustDB

PRK11880.

Enzyme and pathway databases

BioCyc

SPYO160490:SPY0112-MONOMER.
SPYO293653:M5005_SPY0096-MONOMER.

Family and domain databases

InterPro

IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR004455. NADP_OxRdtase_F420.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

PANTHER

PTHR11645. P5CR. 1 hit.

Pfam

PF03807. F420_oxidored. 1 hit.
[Graphical view]

PIRSF

PIRSF000193. Pyrrol-5-carb_rd. 1 hit.

SUPFAM

SSF48179. 6DGDH_C_like. 1 hit.

TIGRFAMs

TIGR00112. ProC. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q9A1S9_STRP1

Accession

Primary (citable) accession number: Q9A1S9
Secondary accession number(s): Q491K3

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)