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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei291Proton donorBy similarity1
Active sitei312By similarity1
Active sitei426By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:SPy_0215, M5005_Spy0185
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807401 – 449Glucose-6-phosphate isomeraseAdd BLAST449

Proteomic databases

PaxDbiQ9A1L1
PRIDEiQ9A1L1

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_0215

Structurei

3D structure databases

ProteinModelPortaliQ9A1L1
SMRiQ9A1L1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
KOiK01810
OMAiVERCKAM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A1L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHITFDYSK VLESFAGQHE IDFLQGQVTE ADKLLREGTG PGSDFLGWLD
60 70 80 90 100
LPENYDKDEF ARILTAAEKI KADSEVLVVI GIGGSYLGAK AAIDFLNHHF
110 120 130 140 150
ANLQTAKERK APQILYAGNS ISSTYLADLV EYVQDKEFSV NVISKSGTTT
160 170 180 190 200
EPAIAFRVFK ELLVKKYGQE EANKRIYATT DKVKGAVKVE ADANNWETFV
210 220 230 240 250
VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD LSSDKISENI
260 270 280 290 300
AYQYAAVRNV LYRKGYITEI LANYEPSLQY FGEWWKQLAG ESEGKDQKGI
310 320 330 340 350
YPTSANFSTD LHSLGQFIQE GYRNLFETVI RVDNPRKNVI IPELAEDLDG
360 370 380 390 400
LGYLQGKDVD FVNKKATDGV LLAHTDGGVP NMFVTLPAQD EFTLGYTIYF
410 420 430 440
FELAIAVSGY MNAVNPFDQP GVEAYKRNMF ALLGKPGFEA LSAELNARL
Length:449
Mass (Da):49,453
Last modified:June 1, 2001 - v1
Checksum:i49B59AFAA0007F33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA Translation: AAK33304.1
CP000017 Genomic DNA Translation: AAZ50804.1
RefSeqiNP_268583.1, NC_002737.2

Genome annotation databases

EnsemblBacteriaiAAK33304; AAK33304; SPy_0215
AAZ50804; AAZ50804; M5005_Spy0185
GeneIDi900528
KEGGispy:SPy_0215
spz:M5005_Spy0185
PATRICifig|160490.10.peg.189

Similar proteinsi

Entry informationi

Entry nameiG6PI_STRP1
AccessioniPrimary (citable) accession number: Q9A1L1
Secondary accession number(s): Q491B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health