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Protein

Glutamate racemase

Gene

murI

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation1 Publication

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton donor/acceptorUniRule annotationBy similarity
Active sitei183 – 1831Proton donor/acceptorUniRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-319-MONOMER.
SPYO293653:GHFC-359-MONOMER.
BRENDAi5.1.1.3. 5935.
SABIO-RKQ9A1B7.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation1 Publication)
Gene namesi
Name:murIUniRule annotation
Synonyms:glr
Ordered Locus Names:SPy_0361, M5005_Spy0303
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Glutamate racemasePRO_0000095521Add
BLAST

Proteomic databases

PaxDbiQ9A1B7.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi160490.SPy_0361.

Structurei

Secondary structure

1
264
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 138Combined sources
Helixi16 – 2510Combined sources
Beta strandi31 – 355Combined sources
Helixi37 – 393Combined sources
Helixi47 – 6216Combined sources
Turni63 – 653Combined sources
Beta strandi67 – 715Combined sources
Helixi74 – 8714Combined sources
Beta strandi92 – 954Combined sources
Helixi96 – 10611Combined sources
Beta strandi108 – 1169Combined sources
Helixi118 – 1236Combined sources
Helixi125 – 1339Combined sources
Beta strandi137 – 1437Combined sources
Helixi147 – 1515Combined sources
Helixi153 – 1553Combined sources
Helixi159 – 16911Combined sources
Turni170 – 1745Combined sources
Beta strandi177 – 1815Combined sources
Helixi186 – 1894Combined sources
Helixi190 – 1978Combined sources
Beta strandi201 – 2055Combined sources
Helixi206 – 22015Combined sources
Beta strandi235 – 2406Combined sources
Helixi242 – 25211Combined sources
Beta strandi259 – 2613Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OHGX-ray2.50A1-264[»]
2OHOX-ray2.25A/B1-264[»]
2OHVX-ray2.50A1-264[»]
ProteinModelPortaliQ9A1B7.
SMRiQ9A1B7. Positions 1-264.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9A1B7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 112Substrate bindingUniRule annotation1 Publication
Regioni42 – 432Substrate bindingUniRule annotationBy similarity
Regioni74 – 752Substrate bindingUniRule annotation1 Publication
Regioni184 – 1852Substrate bindingUniRule annotationBy similarity

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
KOiK01776.
OMAiVPYGSKS.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9A1B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRPIGFLD SGVGGLTVVC ELIRQLPHEK IVYIGDSARA PYGPRPKKQI
60 70 80 90 100
KEYTWELVNF LLTQNVKMIV FACNTATAVA WEEVKAALDI PVLGVVLPGA
110 120 130 140 150
SAAIKSTTKG QVGVIGTPMT VASDIYRKKI QLLAPSIQVR SLACPKFVPI
160 170 180 190 200
VESNEMCSSI AKKIVYDSLA PLVGKIDTLV LGCTHYPLLR PIIQNVMGPS
210 220 230 240 250
VKLIDSGAEC VRDISVLLNY FDINGNYHQK AVEHRFFTTA NPEIFQEIAS
260
IWLKQKINVE HVTL
Length:264
Mass (Da):29,016
Last modified:June 1, 2001 - v1
Checksum:iBD7A535F8B532274
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK33406.1.
CP000017 Genomic DNA. Translation: AAZ50922.1.
RefSeqiNP_268685.1. NC_002737.2.

Genome annotation databases

EnsemblBacteriaiAAK33406; AAK33406; SPy_0361.
AAZ50922; AAZ50922; M5005_Spy0303.
GeneIDi900634.
KEGGispy:SPy_0361.
spz:M5005_Spy0303.
PATRICi19714487. VBIStrPyo79812_0312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK33406.1.
CP000017 Genomic DNA. Translation: AAZ50922.1.
RefSeqiNP_268685.1. NC_002737.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OHGX-ray2.50A1-264[»]
2OHOX-ray2.25A/B1-264[»]
2OHVX-ray2.50A1-264[»]
ProteinModelPortaliQ9A1B7.
SMRiQ9A1B7. Positions 1-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160490.SPy_0361.

Proteomic databases

PaxDbiQ9A1B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK33406; AAK33406; SPy_0361.
AAZ50922; AAZ50922; M5005_Spy0303.
GeneIDi900634.
KEGGispy:SPy_0361.
spz:M5005_Spy0303.
PATRICi19714487. VBIStrPyo79812_0312.

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
KOiK01776.
OMAiVPYGSKS.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciSPYO160490:GJ81-319-MONOMER.
SPYO293653:GHFC-359-MONOMER.
BRENDAi5.1.1.3. 5935.
SABIO-RKQ9A1B7.

Miscellaneous databases

EvolutionaryTraceiQ9A1B7.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMURI_STRP1
AccessioniPrimary (citable) accession number: Q9A1B7
Secondary accession number(s): Q490P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.