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Q9A155 (FTSK_STRP1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA translocase FtsK
Gene names
Name:ftsK
Ordered Locus Names:SPy_0458, M5005_Spy0372
OrganismStreptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]
Taxonomic identifier301447 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length801 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region. Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination By similarity.

Subunit structure

Homohexamer. Forms a ring that surrounds DNA By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: Located at the septum By similarity.

Domain

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain By similarity.

Sequence similarities

Belongs to the FtsK/SpoIIIE/SftA family.

Contains 1 FtsK domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 801801DNA translocase FtsK
PRO_0000098308

Regions

Transmembrane31 – 5323Helical; Potential
Transmembrane58 – 8023Helical; Potential
Transmembrane89 – 11123Helical; Potential
Transmembrane131 – 15020Helical; Potential
Transmembrane155 – 17723Helical; Potential
Topological domain178 – 801624Cytoplasmic Potential
Domain464 – 660197FtsK
Nucleotide binding484 – 4896ATP By similarity

Experimental info

Sequence conflict7111T → A in AAZ50990. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9A155 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 2AEE3CF9E6A93495

FASTA80189,328
        10         20         30         40         50         60 
MVKRNQRKKS APKKRLTKAE VEKQRAIKRM ILSVLMALLL IFAMLRLGVF GVTTYNMIRF 

        70         80         90        100        110        120 
LVGSLAYPFM FAWLIYLFCF KWLRQKDGMI AGVVIAFLGL LVEWHAFLFA MPRMLDQDIF 

       130        140        150        160        170        180 
LGTARLITRD LLALRVTEFV GGGMLGALLY KPIAFLFSNI GSYFIGFLFI LLGLFLMTPW 

       190        200        210        220        230        240 
DIYDVSHFVK EAVDKLAVAY QENKEKRFIK REEHRLQAEK EALEKQAQEE EKRLAELTVD 

       250        260        270        280        290        300 
PETGEIVEDS QSQVSYDLAE DMTKEPEILA YDSHLKDDET SLFDQEDLAY AHEEIGAYDS 

       310        320        330        340        350        360 
LSALASSEDE MDMDEPVEVD FTPKTHLLYK LPTIDLFAPD KPKNQSKEKN LVRKNIKVLE 

       370        380        390        400        410        420 
DTFQSFGIDV KVERAEIGPS VTKYEIKPAV GVRVNRISNL ADDLALALAA KDVRIEAPIP 

       430        440        450        460        470        480 
GKSLIGIEVP NSEIATVSFR ELWEQSDANP ENLLEVPLGK AVNGNARSFN LARMPHLLVA 

       490        500        510        520        530        540 
GSTGSGKSVA VNGIISSILM KARPDQVKFM MIDPKMVELS VYNDIPHLLI PVVTNPRKAS 

       550        560        570        580        590        600 
KALQKVVDEM ENRYELFSKI GVRNIAGYNT KVEEFNASSE QKQIPLPLIV VIVDELADLM 

       610        620        630        640        650        660 
MVASKEVEDA IIRLGQKARA AGIHMILATQ RPSVDVISGL IKANVPSRMA FAVSSGTDSR 

       670        680        690        700        710        720 
TILDENGAEK LLGRGDMLFK PIDENHPVRL QGSFISDDDV ERIVNFIKDQ TEADYDDAFD 

       730        740        750        760        770        780 
PGEVSDNDPG FSGNGGAAEG DPLFEEAKAL VLETQKASAS MIQRRLSVGF NRATRLMDEL 

       790        800 
EEAGVIGPAE GTKPRKVLQT N 

« Hide

References

[1]"Complete genome sequence of an M1 strain of Streptococcus pyogenes."
Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. expand/collapse author list , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E.
Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700294 / SF370 / Serotype M1.
[2]"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004092 Genomic DNA. Translation: AAK33472.1.
CP000017 Genomic DNA. Translation: AAZ50990.1.
RefSeqNP_268751.1. NC_002737.1.
YP_281735.1. NC_007297.1.

3D structure databases

ProteinModelPortalQ9A155.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160490.SPy_0458.

Proteomic databases

PaxDbQ9A155.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK33472; AAK33472; SPy_0458.
AAZ50990; AAZ50990; M5005_Spy0372.
GeneID3572544.
900700.
KEGGspy:SPy_0458.
spz:M5005_Spy_0372.
PATRIC19714635. VBIStrPyo79812_0386.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1674.
HOGENOMHOG000010003.
KOK03466.
OMADQVKFLM.
OrthoDBEOG6S52GD.
ProtClustDBCLSK877051.

Enzyme and pathway databases

BioCycSPYO160490:GJ81-385-MONOMER.
SPYO293653:GHFC-427-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR002543. Cell_div_FtsK/SpoIIIE.
IPR018541. DNA_translocase_Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTSK_STRP1
AccessionPrimary (citable) accession number: Q9A155
Secondary accession number(s): Q490H8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families