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Q9A155

- FTSK_STRP1

UniProt

Q9A155 - FTSK_STRP1

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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region. Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi484 – 4896ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-385-MONOMER.
SPYO293653:GHFC-427-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:SPy_0458, M5005_Spy0372
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Located at the septum.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 801801DNA translocase FtsKPRO_0000098308Add
BLAST

Proteomic databases

PaxDbiQ9A155.

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi160490.SPy_0458.

Structurei

3D structure databases

ProteinModelPortaliQ9A155.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini178 – 801624CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5323HelicalSequence AnalysisAdd
BLAST
Transmembranei58 – 8023HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 11123HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15020HelicalSequence AnalysisAdd
BLAST
Transmembranei155 – 17723HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini464 – 660197FtsKPROSITE-ProRule annotationAdd
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated
Contains 1 FtsK domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1674.
HOGENOMiHOG000010003.
KOiK03466.
OMAiDQVKFLM.
OrthoDBiEOG6S52GD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9A155-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKRNQRKKS APKKRLTKAE VEKQRAIKRM ILSVLMALLL IFAMLRLGVF
60 70 80 90 100
GVTTYNMIRF LVGSLAYPFM FAWLIYLFCF KWLRQKDGMI AGVVIAFLGL
110 120 130 140 150
LVEWHAFLFA MPRMLDQDIF LGTARLITRD LLALRVTEFV GGGMLGALLY
160 170 180 190 200
KPIAFLFSNI GSYFIGFLFI LLGLFLMTPW DIYDVSHFVK EAVDKLAVAY
210 220 230 240 250
QENKEKRFIK REEHRLQAEK EALEKQAQEE EKRLAELTVD PETGEIVEDS
260 270 280 290 300
QSQVSYDLAE DMTKEPEILA YDSHLKDDET SLFDQEDLAY AHEEIGAYDS
310 320 330 340 350
LSALASSEDE MDMDEPVEVD FTPKTHLLYK LPTIDLFAPD KPKNQSKEKN
360 370 380 390 400
LVRKNIKVLE DTFQSFGIDV KVERAEIGPS VTKYEIKPAV GVRVNRISNL
410 420 430 440 450
ADDLALALAA KDVRIEAPIP GKSLIGIEVP NSEIATVSFR ELWEQSDANP
460 470 480 490 500
ENLLEVPLGK AVNGNARSFN LARMPHLLVA GSTGSGKSVA VNGIISSILM
510 520 530 540 550
KARPDQVKFM MIDPKMVELS VYNDIPHLLI PVVTNPRKAS KALQKVVDEM
560 570 580 590 600
ENRYELFSKI GVRNIAGYNT KVEEFNASSE QKQIPLPLIV VIVDELADLM
610 620 630 640 650
MVASKEVEDA IIRLGQKARA AGIHMILATQ RPSVDVISGL IKANVPSRMA
660 670 680 690 700
FAVSSGTDSR TILDENGAEK LLGRGDMLFK PIDENHPVRL QGSFISDDDV
710 720 730 740 750
ERIVNFIKDQ TEADYDDAFD PGEVSDNDPG FSGNGGAAEG DPLFEEAKAL
760 770 780 790 800
VLETQKASAS MIQRRLSVGF NRATRLMDEL EEAGVIGPAE GTKPRKVLQT

N
Length:801
Mass (Da):89,328
Last modified:June 1, 2001 - v1
Checksum:i2AEE3CF9E6A93495
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti711 – 7111T → A in AAZ50990. (PubMed:16088826)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33472.1.
CP000017 Genomic DNA. Translation: AAZ50990.1.
RefSeqiNP_268751.1. NC_002737.1.
YP_281735.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33472; AAK33472; SPy_0458.
AAZ50990; AAZ50990; M5005_Spy0372.
GeneIDi3572544.
900700.
KEGGispy:SPy_0458.
spz:M5005_Spy_0372.
PATRICi19714635. VBIStrPyo79812_0386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33472.1 .
CP000017 Genomic DNA. Translation: AAZ50990.1 .
RefSeqi NP_268751.1. NC_002737.1.
YP_281735.1. NC_007297.1.

3D structure databases

ProteinModelPortali Q9A155.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_0458.

Proteomic databases

PaxDbi Q9A155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK33472 ; AAK33472 ; SPy_0458 .
AAZ50990 ; AAZ50990 ; M5005_Spy0372 .
GeneIDi 3572544.
900700.
KEGGi spy:SPy_0458.
spz:M5005_Spy_0372.
PATRICi 19714635. VBIStrPyo79812_0386.

Phylogenomic databases

eggNOGi COG1674.
HOGENOMi HOG000010003.
KOi K03466.
OMAi DQVKFLM.
OrthoDBi EOG6S52GD.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-385-MONOMER.
SPYO293653:GHFC-427-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50901. FTSK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiFTSK_STRP1
AccessioniPrimary (citable) accession number: Q9A155
Secondary accession number(s): Q490H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3