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Q9A155

- FTSK_STRP1

UniProt

Q9A155 - FTSK_STRP1

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Protein

DNA translocase FtsK

Gene
ftsK, SPy_0458, M5005_Spy0372
Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region. Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi484 – 4896ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-385-MONOMER.
SPYO293653:GHFC-427-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:SPy_0458, M5005_Spy0372
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity
Note: Located at the septum By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5323Helical; Reviewed predictionAdd
BLAST
Transmembranei58 – 8023Helical; Reviewed predictionAdd
BLAST
Transmembranei89 – 11123Helical; Reviewed predictionAdd
BLAST
Transmembranei131 – 15020Helical; Reviewed predictionAdd
BLAST
Transmembranei155 – 17723Helical; Reviewed predictionAdd
BLAST
Topological domaini178 – 801624Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 801801DNA translocase FtsKPRO_0000098308Add
BLAST

Proteomic databases

PaxDbiQ9A155.

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA By similarity.

Protein-protein interaction databases

STRINGi160490.SPy_0458.

Structurei

3D structure databases

ProteinModelPortaliQ9A155.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini464 – 660197FtsKAdd
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain By similarity.

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.
Contains 1 FtsK domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1674.
HOGENOMiHOG000010003.
KOiK03466.
OMAiDQVKFLM.
OrthoDBiEOG6S52GD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9A155-1 [UniParc]FASTAAdd to Basket

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MVKRNQRKKS APKKRLTKAE VEKQRAIKRM ILSVLMALLL IFAMLRLGVF    50
GVTTYNMIRF LVGSLAYPFM FAWLIYLFCF KWLRQKDGMI AGVVIAFLGL 100
LVEWHAFLFA MPRMLDQDIF LGTARLITRD LLALRVTEFV GGGMLGALLY 150
KPIAFLFSNI GSYFIGFLFI LLGLFLMTPW DIYDVSHFVK EAVDKLAVAY 200
QENKEKRFIK REEHRLQAEK EALEKQAQEE EKRLAELTVD PETGEIVEDS 250
QSQVSYDLAE DMTKEPEILA YDSHLKDDET SLFDQEDLAY AHEEIGAYDS 300
LSALASSEDE MDMDEPVEVD FTPKTHLLYK LPTIDLFAPD KPKNQSKEKN 350
LVRKNIKVLE DTFQSFGIDV KVERAEIGPS VTKYEIKPAV GVRVNRISNL 400
ADDLALALAA KDVRIEAPIP GKSLIGIEVP NSEIATVSFR ELWEQSDANP 450
ENLLEVPLGK AVNGNARSFN LARMPHLLVA GSTGSGKSVA VNGIISSILM 500
KARPDQVKFM MIDPKMVELS VYNDIPHLLI PVVTNPRKAS KALQKVVDEM 550
ENRYELFSKI GVRNIAGYNT KVEEFNASSE QKQIPLPLIV VIVDELADLM 600
MVASKEVEDA IIRLGQKARA AGIHMILATQ RPSVDVISGL IKANVPSRMA 650
FAVSSGTDSR TILDENGAEK LLGRGDMLFK PIDENHPVRL QGSFISDDDV 700
ERIVNFIKDQ TEADYDDAFD PGEVSDNDPG FSGNGGAAEG DPLFEEAKAL 750
VLETQKASAS MIQRRLSVGF NRATRLMDEL EEAGVIGPAE GTKPRKVLQT 800
N 801
Length:801
Mass (Da):89,328
Last modified:June 1, 2001 - v1
Checksum:i2AEE3CF9E6A93495
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti711 – 7111T → A in AAZ50990. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33472.1.
CP000017 Genomic DNA. Translation: AAZ50990.1.
RefSeqiNP_268751.1. NC_002737.1.
YP_281735.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33472; AAK33472; SPy_0458.
AAZ50990; AAZ50990; M5005_Spy0372.
GeneIDi3572544.
900700.
KEGGispy:SPy_0458.
spz:M5005_Spy_0372.
PATRICi19714635. VBIStrPyo79812_0386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33472.1 .
CP000017 Genomic DNA. Translation: AAZ50990.1 .
RefSeqi NP_268751.1. NC_002737.1.
YP_281735.1. NC_007297.1.

3D structure databases

ProteinModelPortali Q9A155.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_0458.

Proteomic databases

PaxDbi Q9A155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK33472 ; AAK33472 ; SPy_0458 .
AAZ50990 ; AAZ50990 ; M5005_Spy0372 .
GeneIDi 3572544.
900700.
KEGGi spy:SPy_0458.
spz:M5005_Spy_0372.
PATRICi 19714635. VBIStrPyo79812_0386.

Phylogenomic databases

eggNOGi COG1674.
HOGENOMi HOG000010003.
KOi K03466.
OMAi DQVKFLM.
OrthoDBi EOG6S52GD.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-385-MONOMER.
SPYO293653:GHFC-427-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50901. FTSK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiFTSK_STRP1
AccessioniPrimary (citable) accession number: Q9A155
Secondary accession number(s): Q490H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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