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Q9A155

- FTSK_STRP1

UniProt

Q9A155 - FTSK_STRP1

Protein

DNA translocase FtsK

Gene

ftsK

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region. Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi484 – 4896ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. chromosome segregation Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-385-MONOMER.
    SPYO293653:GHFC-427-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA translocase FtsK
    Gene namesi
    Name:ftsK
    Ordered Locus Names:SPy_0458, M5005_Spy0372
    OrganismiStreptococcus pyogenes serotype M1
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Located at the septum.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 801801DNA translocase FtsKPRO_0000098308Add
    BLAST

    Proteomic databases

    PaxDbiQ9A155.

    Interactioni

    Subunit structurei

    Homohexamer. Forms a ring that surrounds DNA By similarity.By similarity

    Protein-protein interaction databases

    STRINGi160490.SPy_0458.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9A155.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini178 – 801624CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei58 – 8023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 11123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini464 – 660197FtsKPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain By similarity.By similarity

    Sequence similaritiesi

    Belongs to the FtsK/SpoIIIE/SftA family.Curated
    Contains 1 FtsK domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1674.
    HOGENOMiHOG000010003.
    KOiK03466.
    OMAiDQVKFLM.
    OrthoDBiEOG6S52GD.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00843. Ftsk_gamma. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50901. FTSK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9A155-1 [UniParc]FASTAAdd to Basket

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    MVKRNQRKKS APKKRLTKAE VEKQRAIKRM ILSVLMALLL IFAMLRLGVF    50
    GVTTYNMIRF LVGSLAYPFM FAWLIYLFCF KWLRQKDGMI AGVVIAFLGL 100
    LVEWHAFLFA MPRMLDQDIF LGTARLITRD LLALRVTEFV GGGMLGALLY 150
    KPIAFLFSNI GSYFIGFLFI LLGLFLMTPW DIYDVSHFVK EAVDKLAVAY 200
    QENKEKRFIK REEHRLQAEK EALEKQAQEE EKRLAELTVD PETGEIVEDS 250
    QSQVSYDLAE DMTKEPEILA YDSHLKDDET SLFDQEDLAY AHEEIGAYDS 300
    LSALASSEDE MDMDEPVEVD FTPKTHLLYK LPTIDLFAPD KPKNQSKEKN 350
    LVRKNIKVLE DTFQSFGIDV KVERAEIGPS VTKYEIKPAV GVRVNRISNL 400
    ADDLALALAA KDVRIEAPIP GKSLIGIEVP NSEIATVSFR ELWEQSDANP 450
    ENLLEVPLGK AVNGNARSFN LARMPHLLVA GSTGSGKSVA VNGIISSILM 500
    KARPDQVKFM MIDPKMVELS VYNDIPHLLI PVVTNPRKAS KALQKVVDEM 550
    ENRYELFSKI GVRNIAGYNT KVEEFNASSE QKQIPLPLIV VIVDELADLM 600
    MVASKEVEDA IIRLGQKARA AGIHMILATQ RPSVDVISGL IKANVPSRMA 650
    FAVSSGTDSR TILDENGAEK LLGRGDMLFK PIDENHPVRL QGSFISDDDV 700
    ERIVNFIKDQ TEADYDDAFD PGEVSDNDPG FSGNGGAAEG DPLFEEAKAL 750
    VLETQKASAS MIQRRLSVGF NRATRLMDEL EEAGVIGPAE GTKPRKVLQT 800
    N 801
    Length:801
    Mass (Da):89,328
    Last modified:June 1, 2001 - v1
    Checksum:i2AEE3CF9E6A93495
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti711 – 7111T → A in AAZ50990. (PubMed:16088826)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK33472.1.
    CP000017 Genomic DNA. Translation: AAZ50990.1.
    RefSeqiNP_268751.1. NC_002737.1.
    YP_281735.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK33472; AAK33472; SPy_0458.
    AAZ50990; AAZ50990; M5005_Spy0372.
    GeneIDi3572544.
    900700.
    KEGGispy:SPy_0458.
    spz:M5005_Spy_0372.
    PATRICi19714635. VBIStrPyo79812_0386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK33472.1 .
    CP000017 Genomic DNA. Translation: AAZ50990.1 .
    RefSeqi NP_268751.1. NC_002737.1.
    YP_281735.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali Q9A155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160490.SPy_0458.

    Proteomic databases

    PaxDbi Q9A155.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK33472 ; AAK33472 ; SPy_0458 .
    AAZ50990 ; AAZ50990 ; M5005_Spy0372 .
    GeneIDi 3572544.
    900700.
    KEGGi spy:SPy_0458.
    spz:M5005_Spy_0372.
    PATRICi 19714635. VBIStrPyo79812_0386.

    Phylogenomic databases

    eggNOGi COG1674.
    HOGENOMi HOG000010003.
    KOi K03466.
    OMAi DQVKFLM.
    OrthoDBi EOG6S52GD.

    Enzyme and pathway databases

    BioCyci SPYO160490:GJ81-385-MONOMER.
    SPYO293653:GHFC-427-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00843. Ftsk_gamma. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50901. FTSK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700294 / SF370 / Serotype M1.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

    Entry informationi

    Entry nameiFTSK_STRP1
    AccessioniPrimary (citable) accession number: Q9A155
    Secondary accession number(s): Q490H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3