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Q9A0U7

- CAPP_STRP1

UniProt

Q9A0U7 - CAPP_STRP1

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, SPy_0608, M5005_Spy0505
Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381 By similarity
Active sitei583 – 5831 By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-500-MONOMER.
SPYO293653:GHFC-560-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppc
Ordered Locus Names:SPy_0608, M5005_Spy0505
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920Phosphoenolpyruvate carboxylaseUniRule annotation
PRO_0000166632Add
BLAST

Proteomic databases

PaxDbiQ9A0U7.

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_0608.

Structurei

3D structure databases

ProteinModelPortaliQ9A0U7.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiSILNCET.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9A0U7-1 [UniParc]FASTAAdd to Basket

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MPLKKLESSN NQDIIAEEVA LLKEMLENIT RRMIGDDAFT VIESIMVLSE    50
KQDYIELEKV VANISNQEME VISRYFSILP LLINISEDVD LAYEINYQNN 100
TDTDYLGKLA LTIKDLAGKD NGKDILEQVN VVPVLTAHPT QVQRKTILEL 150
TTHIHKLLRK YRDAKAGVIN LEKWRQELYR YIEMIMQTDI IREKKLQVKN 200
EIKNVMQYYD GSLIQAVTKL TTEYKNLAQK HGLELDNPKP ITMGMWIGGD 250
RDGNPFVTAE TLCLSATVQS EVILNYYIDE LAALYRTFSL SSTLVQPNSE 300
VERLASLSQD QSIYRGNEPY RRAFHYIQSR LKQTQIQLTN QPAASMSSSV 350
GLNTSAWSSP ASLENPILAY DSPVDFKADL KAIEQSLLDN GNSALIEGDL 400
REVMQAVDIF GFFLASIDMR QDSSVQEACV AELLKGANIV DDYSSLSETE 450
KCDVLLQQLM EEPRTLSSAA VAKSDLLEKE LAIYTTAREL KDKLGEEVIK 500
QHIISHTESV SDMFELAIML KEVGLVDQQR ARVQIVPLFE TIEDLDNARD 550
IMAAYLSHDI VKSWIATNRN YQEIMLGYSD SNKDGGYLAS GWTLYKAQNE 600
LTAIGEEHGV KITFFHGRGG TVGRGGGPSY DAITSQPFGS IKDRIRLTEQ 650
GEIIENKYGN KDVAYYHLEM LISASINRMV TQMITDPNEI DSFREIMDSI 700
VADSNIIYRK LVFDNPHFYD YFFEASPIKE VSSLNIGSRP AARKTITEIT 750
GLRAIPWVFS WSQNRIMFPG WYGVGSAFKR YIDRAQGNLE RLQHMYQTWP 800
FFHSLLSNVD MVLSKSNMNI AFQYAQLAER QDVRDVFYEI LDEWQLTKNV 850
ILAIQDHDDL LEDNPSLKHS LKSRLPYFNV LNYIQIELIK RWRNNQLDEN 900
DEKLIHTTIN GIATGLRNSG 920
Length:920
Mass (Da):104,752
Last modified:June 1, 2001 - v1
Checksum:i464EA4A309A22237
GO

Sequence cautioni

The sequence AAZ51123.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti345 – 3451S → R in AAZ51123. 1 Publication
Sequence conflicti859 – 8591D → A in AAZ51123. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33584.1.
CP000017 Genomic DNA. Translation: AAZ51123.1. Different initiation.
RefSeqiYP_281868.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33584; AAK33584; SPy_0608.
AAZ51123; AAZ51123; M5005_Spy0505.
GeneIDi3572404.
KEGGispy:SPy_0608.
spz:M5005_Spy_0505.
PATRICi19714903. VBIStrPyo79812_0520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33584.1 .
CP000017 Genomic DNA. Translation: AAZ51123.1 . Different initiation.
RefSeqi YP_281868.1. NC_007297.1.

3D structure databases

ProteinModelPortali Q9A0U7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_0608.

Proteomic databases

PaxDbi Q9A0U7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK33584 ; AAK33584 ; SPy_0608 .
AAZ51123 ; AAZ51123 ; M5005_Spy0505 .
GeneIDi 3572404.
KEGGi spy:SPy_0608.
spz:M5005_Spy_0505.
PATRICi 19714903. VBIStrPyo79812_0520.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi SILNCET.
OrthoDBi EOG6TJ7T8.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-500-MONOMER.
SPYO293653:GHFC-560-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiCAPP_STRP1
AccessioniPrimary (citable) accession number: Q9A0U7
Secondary accession number(s): Q48ZU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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