Hyaluronidase, phage associated - Streptococcus pyogenes serotype M1

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Q9A0M7 (Q9A0M7_STRP1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 52. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Hyaluronidase, phage associated EMBL AAK33657.1

Gene names

Name:	hylP1 EMBL AAK33657.1
Ordered Locus Names:	SPy_0701

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 3EKA PDB 2YX2 PDB 2YW0 PDB 2DP5 PDB 2C3F PDB 2YVV Complete proteome
Gene Ontology (GO)
Biological process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	hyalurononglucosaminidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Region

4

Ascorbic acid 3 binding PDB 3EKA

Sites

Binding site

1

Ascorbic acid 1 PDB 3EKA

Binding site

1

Ascorbic acid 1 PDB 3EKA

Binding site

1

Ascorbic acid 2 PDB 3EKA

Binding site

1

Ascorbic acid 2 PDB 3EKA

Binding site

1

Ascorbic acid 2 PDB 3EKA

Binding site

1

Ascorbic acid 3; via carbonyl oxygen PDB 3EKA

Sequences

Sequence

Length

Mass (Da)

Tools

Q9A0M7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 8F25355EC4158101
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337

36,284

        10         20         30         40         50         60 
MSENIPLRVQ FKRMKAAEWA RSDVILLESE IGFETDTGFA RAGDGHNRFS DLGYISPLDY 

        70         80         90        100        110        120 
NLLTNKPNID GLATKVETAQ KLQQKADKET VYTKAESKQE LDKKLNLKGG VMTGQLKFKP 

       130        140        150        160        170        180 
AATVAYSSST GGAVNIDLSS TRGAGVVVYS DNDTSDGPLM SLRTGKETFN QSALFVDYKG 

       190        200        210        220        230        240 
TTNAVNIAMR QPTTPNFSSA LNITSGNENG SAMQLRGSEK ALGTLKITHE NPSIGADYDK 

       250        260        270        280        290        300 
NAAALSIDIV KKTNGAGTAA QGIYINSTSG TTGKLLRIRN LSDDKFYVKS DGGFYAKETS 

       310        320        330 
QIDGNLKLKD PTANDHAATK AYVDKAISEL KKLILKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. McLaughlin R. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed: 11296296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.
[2]	"Crystal structure of cloned trimeric hyluranidase from streptococcus pyogenes at 2.8 A resolution." Mishra P., Prem Kumar R., Bhakuni V., Singh N., Sharma S., Kaur P., Perbandt M., Betzel C., Singh T.P. Submitted (APR-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS).
[3]	"Polysaccharide binding sites in hyaluronate lyase--crystal structures of native phage-encoded hyaluronate lyase and its complexes with ascorbic acid and lactose." Mishra P., Prem Kumar R., Ethayathulla A.S., Singh N., Sharma S., Perbandt M., Betzel C., Kaur P., Srinivasan A., Bhakuni V., Singh T.P. FEBS J. 276:3392-3402(2009) [PubMed: 19438710] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ASCORBIC ACID.
[4]	"Structure of streptococcus pyogenes bacteriophage-associated hyaluronate lyase Hylp2." Mishra P., Bhakuni V., Prem Kumar R., Singh N., Sharma S., Kaur P., Singh T.P. Submitted (MAY-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (3.55 ANGSTROMS) OF 7-337.
[5]	"Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix." Smith N.L., Taylor E.J., Lindsay A.M., Charnock S.J., Turkenburg J.P., Dodson E.J., Davies G.J., Black G.W. Proc. Natl. Acad. Sci. U.S.A. 102:17652-17657(2005) [PubMed: 16314578] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS) OF 2-337.
[6]	"Crystal structure of hyluranidase complexed with lactose at 2.6 A resolution reveals three specific sugar recognition sites." Mishra P., Prem Kumar R., Singh N., Sharma S., Kaur P., Perbandt M., Betzel C., Bhakuni V., Singh T.P. Submitted (APR-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE004092 Genomic DNA. Translation: AAK33657.1.

RefSeq

NP_268936.1. NC_002737.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2C3F	X-ray	1.81	A	2-337	[»]
2DP5	X-ray	3.55	A	7-337	[»]
2YVV	X-ray	2.60	A	1-337	[»]
2YW0	X-ray	2.60	A	1-337	[»]
2YX2	X-ray	2.80	A	1-337	[»]
3EKA	X-ray	3.10	A	7-337	[»]

ProteinModelPortal

SMR

Q9A0M7. Positions 7-337.

ModBase

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

EnsemblBacteria

EBSTRT00000001167; EBSTRP00000001167; EBSTRG00000001167.

GeneID

GenomeReviews

Gene locus SPy_0701 in contig AE004092_GR.

KEGG

PATRIC

19715059. VBIStrPyo79812_0598.

Organism-specific databases

CMR

Phylogenomic databases

GeneTree

EBGT00050000026642.

HOGENOM

OMA

ProtClustDB

Enzyme and pathway databases

BioCyc

SPYO160490:SPY0701-MONOMER.

Family and domain databases

InterPro

IPR009860. Hyaluronidase_bac.
[Graphical view]

KO

Pfam

PF07212. Hyaluronidase_1. 1 hit.
[Graphical view]

ProtoNet

Entry information

Entry name

Q9A0M7_STRP1

Accession

Primary (citable) accession number: Q9A0M7

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

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Names·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info