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Q99ZX6

- Q99ZX6_STRP1

UniProt

Q99ZX6 - Q99ZX6_STRP1

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Protein
Submitted name:

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Gene

acoC

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-849-MONOMER.
SPYO293653:GHFC-812-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexImported (EC:2.3.1.12Imported)
Submitted name:
Putative dihydrolipoamide S-acetyltransferaseImported (EC:2.3.1.12Imported)
Gene namesi
Name:acoCImported
Ordered Locus Names:M5005_Spy0753Imported, SPy_1029Imported
OrganismiStreptococcus pyogenes serotype M1Imported
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002702: Chromosome

Structurei

3D structure databases

ProteinModelPortaliQ99ZX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000281566.
KOiK00627.
OMAiANEIIMP.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 2 hits.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 2 hits.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 2 hits.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99ZX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFEIIMPKL GVDMQEGEII EWKKQEGDTV NEGDILLEIM SDKTNMELEA
60 70 80 90 100
EDSGVLLKIT RQAGDTVPVT EVIGYIGAEG ESVDTIASSE KTTEIPVPAS
110 120 130 140 150
ADAGPAVAPK ENVASPAPQV AATAIPQGNG GKVRATPAAR KAAAEMGIDL
160 170 180 190 200
GQVPGTGPKG RVHKEDVENF KGAQPKASPL ARKIAADKGI DLATVSGTGF
210 220 230 240 250
NGKVMKEDIM AILEAAKPAE AKAPAAKEEK VVDLPEGVEH KPMSAMRKAI
260 270 280 290 300
SKGMTNSYLT APTFTLNYDI DMTEMIALRK KLIDPIMAKT GLKVSFTDLI
310 320 330 340 350
GMAVVKTLMK PEHEYMNASL INDANDIELH RFVNLGIAVG LDDGLIVPVI
360 370 380 390 400
HGANKMCLSD FVLASKDVIK KAQTGKLKAA EMSGSTFSIT NLGMFGTKTF
410 420 430 440 450
NPIINQPNSA ILGVGATIPT PTVVDGEIVS RPIMAMCLTI DHRLVDGMNG
460
AKFMVDLKKL MENPFELLI
Length:469
Mass (Da):49,802
Last modified:June 1, 2001 - v1
Checksum:i7DCA20273B42B08E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33922.1.
CP000017 Genomic DNA. Translation: AAZ51371.1.
RefSeqiNP_269201.1. NC_002737.1.
YP_282116.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33922; AAK33922; SPy_1029.
AAZ51371; AAZ51371; M5005_Spy0753.
GeneIDi3572157.
901162.
KEGGispy:SPy_1029.
spz:M5005_Spy_0753.
PATRICi19715643. VBIStrPyo79812_0886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33922.1 .
CP000017 Genomic DNA. Translation: AAZ51371.1 .
RefSeqi NP_269201.1. NC_002737.1.
YP_282116.1. NC_007297.1.

3D structure databases

ProteinModelPortali Q99ZX6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK33922 ; AAK33922 ; SPy_1029 .
AAZ51371 ; AAZ51371 ; M5005_Spy0753 .
GeneIDi 3572157.
901162.
KEGGi spy:SPy_1029.
spz:M5005_Spy_0753.
PATRICi 19715643. VBIStrPyo79812_0886.

Phylogenomic databases

HOGENOMi HOG000281566.
KOi K00627.
OMAi ANEIIMP.
OrthoDBi EOG610413.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-849-MONOMER.
SPYO293653:GHFC-812-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 2 hits.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 2 hits.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 2 hits.
SSF51230. SSF51230. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SF370Imported.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported and MGAS5005Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MGAS5005.
  4. "Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences."
    Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W., Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D., Steinbakk M., Lowe D.E., McGeere A., Darenberg J., Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.
    Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2014)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SF370.

Entry informationi

Entry nameiQ99ZX6_STRP1
AccessioniPrimary (citable) accession number: Q99ZX6
Secondary accession number(s): Q48Z47
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3