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Protein
Submitted name:

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Gene

acoC

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-849-MONOMER.
SPYO293653:GHFC-812-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexImported (EC:2.3.1.12Imported)
Submitted name:
Putative dihydrolipoamide S-acetyltransferaseImported (EC:2.3.1.12Imported)
Gene namesi
Name:acoCImported
Ordered Locus Names:M5005_Spy0753Imported, SPy_1029Imported
OrganismiStreptococcus pyogenes serotype M1Imported
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750 Componenti: Chromosome UP000002702 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliQ99ZX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000281566.
KOiK00627.
OMAiATMEFES.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 2 hits.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 2 hits.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 2 hits.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99ZX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFEIIMPKL GVDMQEGEII EWKKQEGDTV NEGDILLEIM SDKTNMELEA
60 70 80 90 100
EDSGVLLKIT RQAGDTVPVT EVIGYIGAEG ESVDTIASSE KTTEIPVPAS
110 120 130 140 150
ADAGPAVAPK ENVASPAPQV AATAIPQGNG GKVRATPAAR KAAAEMGIDL
160 170 180 190 200
GQVPGTGPKG RVHKEDVENF KGAQPKASPL ARKIAADKGI DLATVSGTGF
210 220 230 240 250
NGKVMKEDIM AILEAAKPAE AKAPAAKEEK VVDLPEGVEH KPMSAMRKAI
260 270 280 290 300
SKGMTNSYLT APTFTLNYDI DMTEMIALRK KLIDPIMAKT GLKVSFTDLI
310 320 330 340 350
GMAVVKTLMK PEHEYMNASL INDANDIELH RFVNLGIAVG LDDGLIVPVI
360 370 380 390 400
HGANKMCLSD FVLASKDVIK KAQTGKLKAA EMSGSTFSIT NLGMFGTKTF
410 420 430 440 450
NPIINQPNSA ILGVGATIPT PTVVDGEIVS RPIMAMCLTI DHRLVDGMNG
460
AKFMVDLKKL MENPFELLI
Length:469
Mass (Da):49,802
Last modified:May 31, 2001 - v1
Checksum:i7DCA20273B42B08E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK33922.1.
CP000017 Genomic DNA. Translation: AAZ51371.1.
RefSeqiNP_269201.1. NC_002737.1.
YP_282116.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33922; AAK33922; SPy_1029.
AAZ51371; AAZ51371; M5005_Spy0753.
GeneIDi3572157.
901162.
KEGGispy:SPy_1029.
spz:M5005_Spy_0753.
PATRICi19715643. VBIStrPyo79812_0886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK33922.1.
CP000017 Genomic DNA. Translation: AAZ51371.1.
RefSeqiNP_269201.1. NC_002737.1.
YP_282116.1. NC_007297.1.

3D structure databases

ProteinModelPortaliQ99ZX6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK33922; AAK33922; SPy_1029.
AAZ51371; AAZ51371; M5005_Spy0753.
GeneIDi3572157.
901162.
KEGGispy:SPy_1029.
spz:M5005_Spy_0753.
PATRICi19715643. VBIStrPyo79812_0886.

Phylogenomic databases

HOGENOMiHOG000281566.
KOiK00627.
OMAiATMEFES.
OrthoDBiEOG610413.

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-849-MONOMER.
SPYO293653:GHFC-812-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 2 hits.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 2 hits.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 2 hits.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1Imported and SF370Imported.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported and MGAS5005Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MGAS5005.
  4. "Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences."
    Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W., Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D., Steinbakk M., Lowe D.E., McGeere A., Darenberg J., Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.
    Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2013)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SF370.

Entry informationi

Entry nameiQ99ZX6_STRP1
AccessioniPrimary (citable) accession number: Q99ZX6
Secondary accession number(s): Q48Z47
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2001
Last sequence update: May 31, 2001
Last modified: March 31, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.