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Protein

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Gene

acoC

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

(R)-lipoateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:acoCImported
Ordered Locus Names:SPy_1029Imported
OrganismiStreptococcus pyogenes serotype M1Imported
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiQ99ZX6
PRIDEiQ99ZX6

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_1029

Structurei

3D structure databases

ProteinModelPortaliQ99ZX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 77Lipoyl-bindingInterPro annotationAdd BLAST76
Domaini134 – 171Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38
Domaini176 – 213Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QKR Bacteria
COG0508 LUCA
HOGENOMiHOG000281566
KOiK00627
OMAiFTPIFME

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 2 hits
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 2 hits
SUPFAMiSSF47005 SSF47005, 2 hits
SSF51230 SSF51230, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 2 hits

Sequencei

Sequence statusi: Complete.

Q99ZX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFEIIMPKL GVDMQEGEII EWKKQEGDTV NEGDILLEIM SDKTNMELEA
60 70 80 90 100
EDSGVLLKIT RQAGDTVPVT EVIGYIGAEG ESVDTIASSE KTTEIPVPAS
110 120 130 140 150
ADAGPAVAPK ENVASPAPQV AATAIPQGNG GKVRATPAAR KAAAEMGIDL
160 170 180 190 200
GQVPGTGPKG RVHKEDVENF KGAQPKASPL ARKIAADKGI DLATVSGTGF
210 220 230 240 250
NGKVMKEDIM AILEAAKPAE AKAPAAKEEK VVDLPEGVEH KPMSAMRKAI
260 270 280 290 300
SKGMTNSYLT APTFTLNYDI DMTEMIALRK KLIDPIMAKT GLKVSFTDLI
310 320 330 340 350
GMAVVKTLMK PEHEYMNASL INDANDIELH RFVNLGIAVG LDDGLIVPVI
360 370 380 390 400
HGANKMCLSD FVLASKDVIK KAQTGKLKAA EMSGSTFSIT NLGMFGTKTF
410 420 430 440 450
NPIINQPNSA ILGVGATIPT PTVVDGEIVS RPIMAMCLTI DHRLVDGMNG
460
AKFMVDLKKL MENPFELLI
Length:469
Mass (Da):49,802
Last modified:June 1, 2001 - v1
Checksum:i7DCA20273B42B08E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA Translation: AAK33922.1
RefSeqiNP_269201.1, NC_002737.2

Genome annotation databases

EnsemblBacteriaiAAK33922; AAK33922; SPy_1029
GeneIDi901162
KEGGispy:SPy_1029
PATRICifig|160490.10.peg.886

Entry informationi

Entry nameiQ99ZX6_STRP1
AccessioniPrimary (citable) accession number: Q99ZX6
Secondary accession number(s): Q48Z47
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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