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Q99ZX6

- Q99ZX6_STRP1

UniProt

Q99ZX6 - Q99ZX6_STRP1

Protein
Submitted name:

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Gene

acoC

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationImported, Transferase

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-849-MONOMER.
    SPYO293653:GHFC-812-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexImported (EC:2.3.1.12Imported)
    Submitted name:
    Putative dihydrolipoamide S-acetyltransferaseImported (EC:2.3.1.12Imported)
    Gene namesi
    Name:acoCImported
    Ordered Locus Names:M5005_Spy0753Imported, SPy_1029Imported
    OrganismiStreptococcus pyogenes serotype M1Imported
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002702: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliQ99ZX6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000281566.
    KOiK00627.
    OMAiANEIIMP.
    OrthoDBiEOG610413.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 2 hits.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 2 hits.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 2 hits.
    SSF51230. SSF51230. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99ZX6-1 [UniParc]FASTAAdd to Basket

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    MAFEIIMPKL GVDMQEGEII EWKKQEGDTV NEGDILLEIM SDKTNMELEA    50
    EDSGVLLKIT RQAGDTVPVT EVIGYIGAEG ESVDTIASSE KTTEIPVPAS 100
    ADAGPAVAPK ENVASPAPQV AATAIPQGNG GKVRATPAAR KAAAEMGIDL 150
    GQVPGTGPKG RVHKEDVENF KGAQPKASPL ARKIAADKGI DLATVSGTGF 200
    NGKVMKEDIM AILEAAKPAE AKAPAAKEEK VVDLPEGVEH KPMSAMRKAI 250
    SKGMTNSYLT APTFTLNYDI DMTEMIALRK KLIDPIMAKT GLKVSFTDLI 300
    GMAVVKTLMK PEHEYMNASL INDANDIELH RFVNLGIAVG LDDGLIVPVI 350
    HGANKMCLSD FVLASKDVIK KAQTGKLKAA EMSGSTFSIT NLGMFGTKTF 400
    NPIINQPNSA ILGVGATIPT PTVVDGEIVS RPIMAMCLTI DHRLVDGMNG 450
    AKFMVDLKKL MENPFELLI 469
    Length:469
    Mass (Da):49,802
    Last modified:June 1, 2001 - v1
    Checksum:i7DCA20273B42B08E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK33922.1.
    CP000017 Genomic DNA. Translation: AAZ51371.1.
    RefSeqiNP_269201.1. NC_002737.1.
    YP_282116.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK33922; AAK33922; SPy_1029.
    AAZ51371; AAZ51371; M5005_Spy0753.
    GeneIDi3572157.
    901162.
    KEGGispy:SPy_1029.
    spz:M5005_Spy_0753.
    PATRICi19715643. VBIStrPyo79812_0886.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK33922.1 .
    CP000017 Genomic DNA. Translation: AAZ51371.1 .
    RefSeqi NP_269201.1. NC_002737.1.
    YP_282116.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali Q99ZX6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK33922 ; AAK33922 ; SPy_1029 .
    AAZ51371 ; AAZ51371 ; M5005_Spy0753 .
    GeneIDi 3572157.
    901162.
    KEGGi spy:SPy_1029.
    spz:M5005_Spy_0753.
    PATRICi 19715643. VBIStrPyo79812_0886.

    Phylogenomic databases

    HOGENOMi HOG000281566.
    KOi K00627.
    OMAi ANEIIMP.
    OrthoDBi EOG610413.

    Enzyme and pathway databases

    BioCyci SPYO160490:GJ81-849-MONOMER.
    SPYO293653:GHFC-812-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 2 hits.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 2 hits.
    SSF51230. SSF51230. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SF370Imported.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported and MGAS5005Imported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MGAS5005.
    4. "Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences."
      Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W., Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D., Steinbakk M., Lowe D.E., McGeere A., Darenberg J., Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.
      Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2014)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SF370.

    Entry informationi

    Entry nameiQ99ZX6_STRP1
    AccessioniPrimary (citable) accession number: Q99ZX6
    Secondary accession number(s): Q48Z47
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3