Q99ZX6 (Q99ZX6_STRP1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex EMBL AAZ51371.1
EC=2.3.1.12 EMBL AAZ51371.1

Submitted name:
Putative dihydrolipoamide S-acetyltransferase EMBL AAK33922.1
EC=2.3.1.12 EMBL AAK33922.1

Gene names

Name:	acoC EMBL AAK33922.1
Ordered Locus Names:	M5005_Spy0753, SPy_1029

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

301447 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU003423 Contains 1 lipoyl-binding domain. RuleBase RU000447

Ontologies

Keywords
Domain	Lipoyl SAAS SAAS003016 RuleBase RU000447
Ligand	Pyruvate EMBL AAZ51371.1
Molecular function	Acyltransferase RuleBase RU003765 EMBL AAK33922.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	dihydrolipoyllysine-residue acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q99ZX6 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7DCA20273B42B08E	FASTA	469	49,802
	10 20 30 40 50 60 MAFEIIMPKL GVDMQEGEII EWKKQEGDTV NEGDILLEIM SDKTNMELEA EDSGVLLKIT 70 80 90 100 110 120 RQAGDTVPVT EVIGYIGAEG ESVDTIASSE KTTEIPVPAS ADAGPAVAPK ENVASPAPQV 130 140 150 160 170 180 AATAIPQGNG GKVRATPAAR KAAAEMGIDL GQVPGTGPKG RVHKEDVENF KGAQPKASPL 190 200 210 220 230 240 ARKIAADKGI DLATVSGTGF NGKVMKEDIM AILEAAKPAE AKAPAAKEEK VVDLPEGVEH 250 260 270 280 290 300 KPMSAMRKAI SKGMTNSYLT APTFTLNYDI DMTEMIALRK KLIDPIMAKT GLKVSFTDLI 310 320 330 340 350 360 GMAVVKTLMK PEHEYMNASL INDANDIELH RFVNLGIAVG LDDGLIVPVI HGANKMCLSD 370 380 390 400 410 420 FVLASKDVIK KAQTGKLKAA EMSGSTFSIT NLGMFGTKTF NPIINQPNSA ILGVGATIPT 430 440 450 460 PTVVDGEIVS RPIMAMCLTI DHRLVDGMNG AKFMVDLKKL MENPFELLI

References

[1]

"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.

[2]

"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004092 Genomic DNA. Translation: AAK33922.1. CP000017 Genomic DNA. Translation: AAZ51371.1.
RefSeq	NP_269201.1. NC_002737.1. YP_282116.1. NC_007297.1.
3D structure databases
HSSP	HSSP built from PDB template 1EBD based on UniProtKB P11961.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK33922; AAK33922; SPy_1029. AAZ51371; AAZ51371; M5005_Spy0753.
GeneID	3572157. 901162.
KEGG	spy:SPy_1029. spz:M5005_Spy_0753.
PATRIC	19715643. VBIStrPyo79812_0886.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000281566.
KO	K00627.
OMA	HLLENPM.
ProtClustDB	PRK11856.
Family and domain databases
Gene3D	3.30.559.10. 1 hit. 4.10.320.10. 2 hits.
InterPro	IPR003016. 2-oxoA_DH_lipoyl-BS. IPR001078. 2-oxoacid_DH_actylTfrase. IPR000089. Biotin_lipoyl. IPR023213. CAT-like_dom. IPR004167. E3-bd. IPR011053. Single_hybrid_motif. [Graphical view]
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00364. Biotin_lipoyl. 1 hit. PF02817. E3_binding. 2 hits. [Graphical view]
SUPFAM	SSF47005. E3_bd. 2 hits. SSF51230. Hybrid_motif. 1 hit.
PROSITE	PS50968. BIOTINYL_LIPOYL. 1 hit. PS00189. LIPOYL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q99ZX6_STRP1

Accession

Primary (citable) accession number: Q99ZX6
Secondary accession number(s): Q48Z47

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)