Unreviewed, UniProtKB/TrEMBL Q99ZX4 (Q99ZX4_STRP1)

Names and origin

Protein names

Submitted name:
    Extracellular hyaluronate lyase EMBL AAK33924.1
Submitted name:
    Hyaluronate lyase EMBL AAZ51375.1
    EC=4.2.2.1

Gene names

Name:	hylA EMBL AAK33924.1
Ordered Locus Names:	M5005_Spy0757, SPy_1032

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

301447 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	805 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Molecular function	carbohydrate binding Inferred from electronic annotation. Source: InterPro hyaluronate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q99ZX4-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 953A2D358D2EAB8E	FASTA	805	92,461
	10 20 30 40 50 60 MNTYFCTHHK QLLLYSNLFL SFAMMGQGTA IYADTLTSNS EPNNTYFQTQ TLTTTDSEKK 70 80 90 100 110 120 VVQPQQKDYY TELLDQWNSI IAGNDAYDKT NPDMVTFHNK AEKDAQNIIK SYQGPDHENR 130 140 150 160 170 180 TYLWEHAKDY SASANITKTY RNIEKIAKQI TNPESCYYQD SKAIAIVKDG MAFMYEHAYN 190 200 210 220 230 240 LDRENHQTTG KENKENWWVY EIGTPRAINN TLSLMYPYFT QEEILKYTAP IEKFVPDPTR 250 260 270 280 290 300 FRVRAANFSP FEANSGNLID MGRVKLISGI LRKDDLEISD TIKAIEKVFT LVDEGNGFYQ 310 320 330 340 350 360 DGSLIDHVVT NAQSPLYKKG IAYTGAYGNV LIDGLSQLIP IIQKTKSPIK ADKMATIYHW 370 380 390 400 410 420 INHSFFPIIV RGEMMDMTRG RSISRFNAQS HVAGIEALRA ILRIADMSEE PHRLALKTRI 430 440 450 460 470 480 KTLVTQGNAF YNVYDNLKTY HDIKLMKELL SDTSVPVQKL DSYVASFNSM DKLALYNNKH 490 500 510 520 530 540 DFAFGLSMFS NRTQNYEAMN NENLHGWFTS DGMFYLYNND LGHYSENYWA TVNPYRLPGT 550 560 570 580 590 600 TETEQKPLEG TPENIKTNYQ QVGMTGLSDD AFVASKKLNN TSALAAMTFT NWNKSLTLNK 610 620 630 640 650 660 GWFILGNKII FVGSNIKNQS SHKAYTTIEQ RKENQKYPYC SYVNNQPVDL NNQLVDFTNT 670 680 690 700 710 720 KSIFLESDDP AQNIGYYFFK PTTLSISKAL QTGKWQNIKA DDKSPEAIKE VSNTFITIMQ 730 740 750 760 770 780 NHTQDGDRYA YMMLPNMTRQ EFETYISKLD IDLLENNDKL AAVYDHDSQQ MHVIHYGKKA 790 800 TMFSNHNLSH QGFYSFPHPV RQNQQ

References

[1]

"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed: 11296296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.

[2]

"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed: 16088826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE004092 Genomic DNA. Translation: AAK33924.1. CP000017 Genomic DNA. Translation: AAZ51375.1.
RefSeq	NP_269203.1. YP_282120.1.
3D structure databases
HSSP	HSSP built from PDB template 1LXM based on UniProtKB Q53591.
ModBase	Search...
Protein family/group databases
CAZy	PL8. Polysaccharide Lyase Family 8.
Genome annotation databases
GeneID	3572161. 901164.
GenomeReviews	Gene locus M5005_Spy0757 in contig AE004092_GR. Gene locus hylA in contig CP000017_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q99ZX4.
OMA	Q99ZX4. GELMDMS.
Enzyme and pathway databases
BioCyc	SPYO160490:SPY1032-MON. SPYO293653:M5005_SPY0757-MON.
Family and domain databases
InterPro	IPR014718. Glyco_hydro-type_carb-bd_sub. IPR012970. Lyase_8_alpha_N. IPR003159. Lyase_8_central. IPR012329. Lyase_8_N. [Graphical view]
Gene3D	G3DSA:2.70.98.10. Glyco_hydro_42_D5. 1 hit. G3DSA:1.50.10.100. Lyase_8_N. 1 hit.
Pfam	PF02278. Lyase_8. 1 hit. PF08124. Lyase_8_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q99ZX4_STRP1

Accession

Primary (citable) accession number: Q99ZX4
Secondary accession number(s): Q48Z43

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)