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Protein
Submitted name:

Lysyl aminopeptidase/alanine aminopeptidase

Gene

pepN

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. metallopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AminopeptidaseImported, Hydrolase, Protease

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1026-MONOMER.
SPYO293653:GHFC-1008-MONOMER.

Protein family/group databases

MEROPSiM01.010.

Names & Taxonomyi

Protein namesi
Submitted name:
Lysyl aminopeptidase/alanine aminopeptidaseImported (EC:3.4.11.15Imported, EC:3.4.11.2Imported)
Submitted name:
Putative lysyl-aminopeptidase aminopeptidase NImported (EC:3.4.11.15Imported)
Gene namesi
Name:pepNImported
Ordered Locus Names:M5005_Spy0949Imported, SPy_1239Imported
OrganismiStreptococcus pyogenes serotype M1Imported
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750 Componenti: Chromosome UP000002702 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliQ99ZG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000235375.
KOiK01256.
OMAiIVPKDRV.
OrthoDBiEOG693GJ0.

Family and domain databases

InterProiIPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.

Sequencei

Sequence statusi: Complete.

Q99ZG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTVEHLIET FVPENYNIFL DINRQTKTFT GNVAINGEAL DNHVAFHQKD
60 70 80 90 100
LDIKSILLDN EAVIYQVDND NEVVRVELPE TGMMTLVIEF SGSITDNMTG
110 120 130 140 150
IYPSYYTKNG EKKEVISTQF ESHFAREAFP CIDEPQAKAT FDLSLTFDQE
160 170 180 190 200
IGEIALSNMP EVNIDRREET GLWTFDTTLR MSSYLLAFAL GELHGKTVES
210 220 230 240 250
KKGTTVGVYA TTAHPLSSLD FSLDIAVRVI NFYEDYFGVH YPIPQSLNIA
260 270 280 290 300
LPDFSSGAME NWGLITYREI YLLVDENSTV QSRQQVALVI AHEIAHQWFG
310 320 330 340 350
NLVTMKWWDD LWLNESFANM MEYVSIEAIE PSWKIIEDFQ TGGIPLALKR
360 370 380 390 400
DATDGVQSVH VEVNHPDEIN TLFDPAIVYA KGSRLMHMLR RFIGDRDFAI
410 420 430 440 450
GLHHYFEKYQ YRNTVGRDLW NILSDTSGKD VAAFMDAWLE QPGYPVLTAR
460 470 480 490 500
LENDQLILSQ KQFFIGKGEE KGRLWPIPLN TNWHGLPETL TEAEMVIPNF
510 520 530 540 550
SQLAAENEGA LRFNIDNTAH YITDYQGSLL DALVTELAQL DNTSALQVIQ
560 570 580 590 600
ERRLLADSGL ISYAELVDLI AQLDDSKSYM VAEAVQQVVS GLKRFIDEGS
610 620 630 640 650
LAEKSFNRLV TTIYQEDFNQ HGFEKKADES DEDEMVRQVA LGRLWLAENQ
660 670 680 690 700
TIIDGLRTIF EAYQNNIASI PAAVRRLVLA NQMKYFETDS LVDIYFETYV
710 720 730 740 750
ATTDNNLRSD LTVAFSQTKQ PTTIRRILVS LKDKDIIKPQ DLSYWYNALL
760 770 780 790 800
GQSFTQDIIW EWARENWDWI KSALGGDMSF DKFVIYPASN FKTPKHLAEY
810 820 830 840
KSFFEPKLDD MAISRNITMG INEIEARVAL ITKEKEAVIA ALSHY
Length:845
Mass (Da):96,349
Last modified:May 31, 2001 - v1
Checksum:i6C19DD284274B420
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34094.1.
CP000017 Genomic DNA. Translation: AAZ51567.1.
RefSeqiNP_269373.1. NC_002737.1.
YP_282312.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34094; AAK34094; SPy_1239.
AAZ51567; AAZ51567; M5005_Spy0949.
GeneIDi3571963.
901339.
KEGGispy:SPy_1239.
spz:M5005_Spy_0949.
PATRICi19716033. VBIStrPyo79812_1081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34094.1.
CP000017 Genomic DNA. Translation: AAZ51567.1.
RefSeqiNP_269373.1. NC_002737.1.
YP_282312.1. NC_007297.1.

3D structure databases

ProteinModelPortaliQ99ZG7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM01.010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK34094; AAK34094; SPy_1239.
AAZ51567; AAZ51567; M5005_Spy0949.
GeneIDi3571963.
901339.
KEGGispy:SPy_1239.
spz:M5005_Spy_0949.
PATRICi19716033. VBIStrPyo79812_1081.

Phylogenomic databases

HOGENOMiHOG000235375.
KOiK01256.
OMAiIVPKDRV.
OrthoDBiEOG693GJ0.

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1026-MONOMER.
SPYO293653:GHFC-1008-MONOMER.

Family and domain databases

InterProiIPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1Imported and SF370Imported.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported and MGAS5005Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MGAS5005.
  4. "Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences."
    Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W., Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D., Steinbakk M., Lowe D.E., McGeere A., Darenberg J., Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.
    Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2013)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SF370.

Entry informationi

Entry nameiQ99ZG7_STRP1
AccessioniPrimary (citable) accession number: Q99ZG7
Secondary accession number(s): Q48YK5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2001
Last sequence update: May 31, 2001
Last modified: March 31, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.