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Q99ZG7

- Q99ZG7_STRP1

UniProt

Q99ZG7 - Q99ZG7_STRP1

Protein
Submitted name:

Lysyl aminopeptidase/alanine aminopeptidase

Gene

pepN

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. metallopeptidase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    AminopeptidaseImported, Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-1026-MONOMER.
    SPYO293653:GHFC-1008-MONOMER.

    Protein family/group databases

    MEROPSiM01.002.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Lysyl aminopeptidase/alanine aminopeptidaseImported (EC:3.4.11.15Imported, EC:3.4.11.2Imported)
    Submitted name:
    Putative lysyl-aminopeptidase aminopeptidase NImported (EC:3.4.11.15Imported)
    Gene namesi
    Name:pepNImported
    Ordered Locus Names:M5005_Spy0949Imported, SPy_1239Imported
    OrganismiStreptococcus pyogenes serotype M1Imported
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002702: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliQ99ZG7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000235375.
    KOiK01256.
    OMAiYLDINRE.
    OrthoDBiEOG693GJ0.

    Family and domain databases

    InterProiIPR024571. ERAP1-like_C_dom.
    IPR001930. Peptidase_M1.
    IPR014782. Peptidase_M1_N.
    [Graphical view]
    PANTHERiPTHR11533. PTHR11533. 1 hit.
    PfamiPF11838. ERAP1_C. 1 hit.
    PF01433. Peptidase_M1. 1 hit.
    [Graphical view]
    PRINTSiPR00756. ALADIPTASE.

    Sequencei

    Sequence statusi: Complete.

    Q99ZG7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTVEHLIET FVPENYNIFL DINRQTKTFT GNVAINGEAL DNHVAFHQKD    50
    LDIKSILLDN EAVIYQVDND NEVVRVELPE TGMMTLVIEF SGSITDNMTG 100
    IYPSYYTKNG EKKEVISTQF ESHFAREAFP CIDEPQAKAT FDLSLTFDQE 150
    IGEIALSNMP EVNIDRREET GLWTFDTTLR MSSYLLAFAL GELHGKTVES 200
    KKGTTVGVYA TTAHPLSSLD FSLDIAVRVI NFYEDYFGVH YPIPQSLNIA 250
    LPDFSSGAME NWGLITYREI YLLVDENSTV QSRQQVALVI AHEIAHQWFG 300
    NLVTMKWWDD LWLNESFANM MEYVSIEAIE PSWKIIEDFQ TGGIPLALKR 350
    DATDGVQSVH VEVNHPDEIN TLFDPAIVYA KGSRLMHMLR RFIGDRDFAI 400
    GLHHYFEKYQ YRNTVGRDLW NILSDTSGKD VAAFMDAWLE QPGYPVLTAR 450
    LENDQLILSQ KQFFIGKGEE KGRLWPIPLN TNWHGLPETL TEAEMVIPNF 500
    SQLAAENEGA LRFNIDNTAH YITDYQGSLL DALVTELAQL DNTSALQVIQ 550
    ERRLLADSGL ISYAELVDLI AQLDDSKSYM VAEAVQQVVS GLKRFIDEGS 600
    LAEKSFNRLV TTIYQEDFNQ HGFEKKADES DEDEMVRQVA LGRLWLAENQ 650
    TIIDGLRTIF EAYQNNIASI PAAVRRLVLA NQMKYFETDS LVDIYFETYV 700
    ATTDNNLRSD LTVAFSQTKQ PTTIRRILVS LKDKDIIKPQ DLSYWYNALL 750
    GQSFTQDIIW EWARENWDWI KSALGGDMSF DKFVIYPASN FKTPKHLAEY 800
    KSFFEPKLDD MAISRNITMG INEIEARVAL ITKEKEAVIA ALSHY 845
    Length:845
    Mass (Da):96,349
    Last modified:June 1, 2001 - v1
    Checksum:i6C19DD284274B420
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34094.1.
    CP000017 Genomic DNA. Translation: AAZ51567.1.
    RefSeqiNP_269373.1. NC_002737.1.
    YP_282312.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK34094; AAK34094; SPy_1239.
    AAZ51567; AAZ51567; M5005_Spy0949.
    GeneIDi3571963.
    901339.
    KEGGispy:SPy_1239.
    spz:M5005_Spy_0949.
    PATRICi19716033. VBIStrPyo79812_1081.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34094.1 .
    CP000017 Genomic DNA. Translation: AAZ51567.1 .
    RefSeqi NP_269373.1. NC_002737.1.
    YP_282312.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali Q99ZG7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M01.002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK34094 ; AAK34094 ; SPy_1239 .
    AAZ51567 ; AAZ51567 ; M5005_Spy0949 .
    GeneIDi 3571963.
    901339.
    KEGGi spy:SPy_1239.
    spz:M5005_Spy_0949.
    PATRICi 19716033. VBIStrPyo79812_1081.

    Phylogenomic databases

    HOGENOMi HOG000235375.
    KOi K01256.
    OMAi YLDINRE.
    OrthoDBi EOG693GJ0.

    Enzyme and pathway databases

    BioCyci SPYO160490:GJ81-1026-MONOMER.
    SPYO293653:GHFC-1008-MONOMER.

    Family and domain databases

    InterProi IPR024571. ERAP1-like_C_dom.
    IPR001930. Peptidase_M1.
    IPR014782. Peptidase_M1_N.
    [Graphical view ]
    PANTHERi PTHR11533. PTHR11533. 1 hit.
    Pfami PF11838. ERAP1_C. 1 hit.
    PF01433. Peptidase_M1. 1 hit.
    [Graphical view ]
    PRINTSi PR00756. ALADIPTASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SF370Imported.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported and MGAS5005Imported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MGAS5005.
    4. "Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences."
      Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W., Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D., Steinbakk M., Lowe D.E., McGeere A., Darenberg J., Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.
      Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2014)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SF370.

    Entry informationi

    Entry nameiQ99ZG7_STRP1
    AccessioniPrimary (citable) accession number: Q99ZG7
    Secondary accession number(s): Q48YK5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3