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Q99ZD3

- GLMS_STRP1

UniProt

Q99ZD3 - GLMS_STRP1

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, SPy_1280, M5005_Spy0986
Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei599 – 5991For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1060-MONOMER.
SPYO293653:GHFC-1045-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:SPy_1280, M5005_Spy0986
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 604603Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135393Add
BLAST

Proteomic databases

PaxDbiQ99ZD3.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi160490.SPy_1280.

Structurei

3D structure databases

ProteinModelPortaliQ99ZD3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2
Add
BLAST
Domaini284 – 423140SIS 1
Add
BLAST
Domaini456 – 594139SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiSVFETQT.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99ZD3-1 [UniParc]FASTAAdd to Basket

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MCGIVGVVGN RNATDILMQG LEKLEYRGYD SAGIFVANAN QTNLIKSVGR    50
IADLRAKIGI DVAGSTGIGH TRWATHGQST EDNAHPHTSQ TGRFVLVHNG 100
VIENYLHIKT EFLAGHDFKG QTDTEIAVHL IGKFVEEDKL SVLEAFKKSL 150
SIIEGSYAFA LMDSQATDTI YVAKNKSPLL IGLGEGYNMV CSDAMAMIRE 200
TSEFMEIHDK ELVILTKDKV TVTDYDGKEL IRDSYTAELD LSDIGKGTYP 250
FYMLKEIDEQ PTVMRQLIST YADETGNVQV DPAIITSIQE ADRLYILAAG 300
TSYHAGFATK NMLEQLTDTP VELGVASEWG YHMPLLSKKP MFILLSQSGE 350
TADSRQVLVK ANAMGIPSLT VTNVPGSTLS REATYTMLIH AGPEIAVAST 400
KAYTAQIAAL AFLAKAVGEA NGKQEALDFN LVHELSLVAQ SIEATLSEKD 450
LVAEKVQALL ATTRNAFYIG RGNDYYVAME AALKLKEISY IQCEGFAAGE 500
LKHGTISLIE EDTPVIALIS SSQLVASHTR GNIQEVAARG AHVLTVVEEG 550
LDREGDDIIV NKVHPFLAPI AMVIPTQLIA YYASLQRGLD VDKPRNLAKA 600
VTVE 604
Length:604
Mass (Da):65,593
Last modified:January 23, 2007 - v3
Checksum:i4EAE8D88FDB3E10C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti452 – 4521V → A in AAZ51604. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34128.1.
CP000017 Genomic DNA. Translation: AAZ51604.1.
RefSeqiNP_269407.1. NC_002737.1.
YP_282349.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34128; AAK34128; SPy_1280.
AAZ51604; AAZ51604; M5005_Spy0986.
GeneIDi3571922.
901373.
KEGGispy:SPy_1280.
spz:M5005_Spy_0986.
PATRICi19716107. VBIStrPyo79812_1118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34128.1 .
CP000017 Genomic DNA. Translation: AAZ51604.1 .
RefSeqi NP_269407.1. NC_002737.1.
YP_282349.1. NC_007297.1.

3D structure databases

ProteinModelPortali Q99ZD3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_1280.

Proteomic databases

PaxDbi Q99ZD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34128 ; AAK34128 ; SPy_1280 .
AAZ51604 ; AAZ51604 ; M5005_Spy0986 .
GeneIDi 3571922.
901373.
KEGGi spy:SPy_1280.
spz:M5005_Spy_0986.
PATRICi 19716107. VBIStrPyo79812_1118.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi SVFETQT.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-1060-MONOMER.
SPYO293653:GHFC-1045-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiGLMS_STRP1
AccessioniPrimary (citable) accession number: Q99ZD3
Secondary accession number(s): Q48YG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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