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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140GTPUniRule annotation1
Binding sitei144GTPUniRule annotation1
Binding sitei188GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 26GTPUniRule annotation5
Nucleotide bindingi109 – 111GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotationImported
Ordered Locus Names:SPy_1520Imported
OrganismiStreptococcus pyogenes serotype M1Imported
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ99YV7
PRIDEiQ99YV7

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi160490.SPy_1520

Structurei

3D structure databases

ProteinModelPortaliQ99YV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 206TubulinInterPro annotationAdd BLAST193
Domaini208 – 325Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK Bacteria
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q99YV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSFDTASI QGAIIKVIGV GGGGGNAINR MIDEGVAGVE FIAANTDIQA
60 70 80 90 100
LSSSKAETVI QLGPKLTRGL GAGGQPEVGR KAAEESEEIL TEALTGADMV
110 120 130 140 150
FITAGMGGGS GTGAAPVIAR IAKSLGALTV AVVTRPFGFE GNKRGNFAIE
160 170 180 190 200
GIEELREQVD TLLIISNNNL LEIVDKKTPL LEALSEADNV LRQGVQGITD
210 220 230 240 250
LITSPGLINL DFADVKTVMA NKGNALMGIG IGSGEERIVE AARKAIYSPL
260 270 280 290 300
LETTIDGAQD VIVNVTGGLD MTLTEAEEAS EIVGQAAGQG VNIWLGTSID
310 320 330 340 350
DTMKDDIRVT VVATGVRQEK AEQVSGFRQP RTFTQTNAQQ VAGAQYASDQ
360 370 380 390 400
AKQSVQPGFD RRSNFDFDMG ESREIPSAQK VISNHNQNQG SAFGNWDLRR
410 420 430
DNISRPTEGE LDNHLNMSTF SANDDSDDEL ETPPFFKNR
Length:439
Mass (Da):46,432
Last modified:June 1, 2001 - v1
Checksum:iE8872562C15A3836
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA Translation: AAK34315.1
RefSeqiNP_269594.1, NC_002737.2

Genome annotation databases

EnsemblBacteriaiAAK34315; AAK34315; SPy_1520
GeneIDi901565
KEGGispy:SPy_1520
PATRICifig|160490.10.peg.1326

Similar proteinsi

Entry informationi

Entry nameiQ99YV7_STRP1
AccessioniPrimary (citable) accession number: Q99YV7
Secondary accession number(s): Q48XQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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