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Q99YU0

- ASNA_STRP1

UniProt

Q99YU0 - ASNA_STRP1

Protein

Aspartate--ammonia ligase

Gene

asnA

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. aminoacyl-tRNA ligase activity Source: InterPro
    2. aspartate-ammonia ligase activity Source: UniProtKB-EC
    3. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. L-asparagine biosynthetic process Source: UniProtKB-UniPathway
    2. tRNA aminoacylation for protein translation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Asparagine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-1270-MONOMER.
    SPYO293653:GHFC-1328-MONOMER.
    UniPathwayiUPA00134; UER00194.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate--ammonia ligaseUniRule annotation (EC:6.3.1.1UniRule annotation)
    Alternative name(s):
    Asparagine synthetase AUniRule annotation
    Gene namesi
    Name:asnAUniRule annotation
    Ordered Locus Names:SPy_1539, M5005_Spy1269
    OrganismiStreptococcus pyogenes serotype M1
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Aspartate--ammonia ligasePRO_0000195893Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi160490.SPy_1539.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99YU0.
    SMRiQ99YU0. Positions 4-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2502.
    HOGENOMiHOG000284502.
    KOiK01914.
    OMAiKLPFHQM.
    OrthoDBiEOG64V2FB.

    Family and domain databases

    HAMAPiMF_00555. AsnA.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004618. AsnA.
    [Graphical view]
    PfamiPF03590. AsnA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001555. Asp_ammon_ligase. 1 hit.
    TIGRFAMsiTIGR00669. asnA. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99YU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKSFIHQQE EISFVKNTFT QYLIAKLDVV EVQGPILSRV GDGMQDNLSG    50
    TENPVSVNVL KIPNATFEVV HSLAKWKRHT LARFGFNEGE GLVVNMKALR 100
    PDEDSLDQTH SVYVDQWDWE KVIPDGKRNL AYLKETVETI YKVIRLTELA 150
    VEARYDIEAV LPKKITFIHT EELVAKYPDL TPKERENAIT KEFGAVFLIG 200
    IGGVLPDGKP HDGRAPDYDD WTTETENGYH GLNGDILVWN DQLGSAFELS 250
    SMGIRVDEEA LKRQVEMTGD QDRLGFDWHK SLLNGLFPLT IGGGIGQSRM 300
    VMFLLRKQHI GEVQTSVWPQ EVRDSYDNIL 330
    Length:330
    Mass (Da):37,385
    Last modified:June 1, 2001 - v1
    Checksum:iB95B324CB73382D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34333.1.
    CP000017 Genomic DNA. Translation: AAZ51887.1.
    RefSeqiNP_269612.1. NC_002737.1.
    YP_282632.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK34333; AAK34333; SPy_1539.
    AAZ51887; AAZ51887; M5005_Spy1269.
    GeneIDi3571620.
    901583.
    KEGGispy:SPy_1539.
    spz:M5005_Spy_1269.
    PATRICi19716564. VBIStrPyo79812_1346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34333.1 .
    CP000017 Genomic DNA. Translation: AAZ51887.1 .
    RefSeqi NP_269612.1. NC_002737.1.
    YP_282632.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali Q99YU0.
    SMRi Q99YU0. Positions 4-330.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160490.SPy_1539.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK34333 ; AAK34333 ; SPy_1539 .
    AAZ51887 ; AAZ51887 ; M5005_Spy1269 .
    GeneIDi 3571620.
    901583.
    KEGGi spy:SPy_1539.
    spz:M5005_Spy_1269.
    PATRICi 19716564. VBIStrPyo79812_1346.

    Phylogenomic databases

    eggNOGi COG2502.
    HOGENOMi HOG000284502.
    KOi K01914.
    OMAi KLPFHQM.
    OrthoDBi EOG64V2FB.

    Enzyme and pathway databases

    UniPathwayi UPA00134 ; UER00194 .
    BioCyci SPYO160490:GJ81-1270-MONOMER.
    SPYO293653:GHFC-1328-MONOMER.

    Family and domain databases

    HAMAPi MF_00555. AsnA.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004618. AsnA.
    [Graphical view ]
    Pfami PF03590. AsnA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001555. Asp_ammon_ligase. 1 hit.
    TIGRFAMsi TIGR00669. asnA. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700294 / SF370 / Serotype M1.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

    Entry informationi

    Entry nameiASNA_STRP1
    AccessioniPrimary (citable) accession number: Q99YU0
    Secondary accession number(s): Q48XN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3