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Q99YU0

- ASNA_STRP1

UniProt

Q99YU0 - ASNA_STRP1

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Protein

Aspartate--ammonia ligase

Gene

asnA

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. aminoacyl-tRNA ligase activity Source: InterPro
  2. aspartate-ammonia ligase activity Source: UniProtKB-EC
  3. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. L-asparagine biosynthetic process Source: UniProtKB-UniPathway
  2. tRNA aminoacylation for protein translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Asparagine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1270-MONOMER.
SPYO293653:GHFC-1328-MONOMER.
UniPathwayiUPA00134; UER00194.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate--ammonia ligaseUniRule annotation (EC:6.3.1.1UniRule annotation)
Alternative name(s):
Asparagine synthetase AUniRule annotation
Gene namesi
Name:asnAUniRule annotation
Ordered Locus Names:SPy_1539, M5005_Spy1269
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Aspartate--ammonia ligasePRO_0000195893Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_1539.

Structurei

3D structure databases

ProteinModelPortaliQ99YU0.
SMRiQ99YU0. Positions 4-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2502.
HOGENOMiHOG000284502.
KOiK01914.
OMAiKLPFHQM.
OrthoDBiEOG64V2FB.

Family and domain databases

HAMAPiMF_00555. AsnA.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004618. AsnA.
[Graphical view]
PfamiPF03590. AsnA. 1 hit.
[Graphical view]
PIRSFiPIRSF001555. Asp_ammon_ligase. 1 hit.
TIGRFAMsiTIGR00669. asnA. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99YU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKSFIHQQE EISFVKNTFT QYLIAKLDVV EVQGPILSRV GDGMQDNLSG
60 70 80 90 100
TENPVSVNVL KIPNATFEVV HSLAKWKRHT LARFGFNEGE GLVVNMKALR
110 120 130 140 150
PDEDSLDQTH SVYVDQWDWE KVIPDGKRNL AYLKETVETI YKVIRLTELA
160 170 180 190 200
VEARYDIEAV LPKKITFIHT EELVAKYPDL TPKERENAIT KEFGAVFLIG
210 220 230 240 250
IGGVLPDGKP HDGRAPDYDD WTTETENGYH GLNGDILVWN DQLGSAFELS
260 270 280 290 300
SMGIRVDEEA LKRQVEMTGD QDRLGFDWHK SLLNGLFPLT IGGGIGQSRM
310 320 330
VMFLLRKQHI GEVQTSVWPQ EVRDSYDNIL
Length:330
Mass (Da):37,385
Last modified:June 1, 2001 - v1
Checksum:iB95B324CB73382D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34333.1.
CP000017 Genomic DNA. Translation: AAZ51887.1.
RefSeqiNP_269612.1. NC_002737.1.
YP_282632.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34333; AAK34333; SPy_1539.
AAZ51887; AAZ51887; M5005_Spy1269.
GeneIDi3571620.
901583.
KEGGispy:SPy_1539.
spz:M5005_Spy_1269.
PATRICi19716564. VBIStrPyo79812_1346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34333.1 .
CP000017 Genomic DNA. Translation: AAZ51887.1 .
RefSeqi NP_269612.1. NC_002737.1.
YP_282632.1. NC_007297.1.

3D structure databases

ProteinModelPortali Q99YU0.
SMRi Q99YU0. Positions 4-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_1539.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34333 ; AAK34333 ; SPy_1539 .
AAZ51887 ; AAZ51887 ; M5005_Spy1269 .
GeneIDi 3571620.
901583.
KEGGi spy:SPy_1539.
spz:M5005_Spy_1269.
PATRICi 19716564. VBIStrPyo79812_1346.

Phylogenomic databases

eggNOGi COG2502.
HOGENOMi HOG000284502.
KOi K01914.
OMAi KLPFHQM.
OrthoDBi EOG64V2FB.

Enzyme and pathway databases

UniPathwayi UPA00134 ; UER00194 .
BioCyci SPYO160490:GJ81-1270-MONOMER.
SPYO293653:GHFC-1328-MONOMER.

Family and domain databases

HAMAPi MF_00555. AsnA.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004618. AsnA.
[Graphical view ]
Pfami PF03590. AsnA. 1 hit.
[Graphical view ]
PIRSFi PIRSF001555. Asp_ammon_ligase. 1 hit.
TIGRFAMsi TIGR00669. asnA. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiASNA_STRP1
AccessioniPrimary (citable) accession number: Q99YU0
Secondary accession number(s): Q48XN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3