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Protein

Aspartate--ammonia ligase

Gene

asnA

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.UniRule annotation

Pathwayi: L-asparagine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-asparagine from L-aspartate (ammonia route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Aspartate--ammonia ligase (asnA)
This subpathway is part of the pathway L-asparagine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-asparagine from L-aspartate (ammonia route), the pathway L-asparagine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Asparagine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00134; UER00194

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate--ammonia ligaseUniRule annotation (EC:6.3.1.1UniRule annotation)
Alternative name(s):
Asparagine synthetase AUniRule annotation
Gene namesi
Name:asnAUniRule annotation
Ordered Locus Names:SPy_1539, M5005_Spy1269
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958931 – 330Aspartate--ammonia ligaseAdd BLAST330

Proteomic databases

PaxDbiQ99YU0
PRIDEiQ99YU0

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_1539

Structurei

3D structure databases

ProteinModelPortaliQ99YU0
SMRiQ99YU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CU9 Bacteria
COG2502 LUCA
HOGENOMiHOG000284502
KOiK01914
OMAiQSRICMF

Family and domain databases

CDDicd00645 AsnA, 1 hit
HAMAPiMF_00555 AsnA, 1 hit
InterProiView protein in InterPro
IPR006195 aa-tRNA-synth_II
IPR004618 AsnA
PANTHERiPTHR30073 PTHR30073, 1 hit
PfamiView protein in Pfam
PF03590 AsnA, 1 hit
PIRSFiPIRSF001555 Asp_ammon_ligase, 1 hit
TIGRFAMsiTIGR00669 asnA, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q99YU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSFIHQQE EISFVKNTFT QYLIAKLDVV EVQGPILSRV GDGMQDNLSG
60 70 80 90 100
TENPVSVNVL KIPNATFEVV HSLAKWKRHT LARFGFNEGE GLVVNMKALR
110 120 130 140 150
PDEDSLDQTH SVYVDQWDWE KVIPDGKRNL AYLKETVETI YKVIRLTELA
160 170 180 190 200
VEARYDIEAV LPKKITFIHT EELVAKYPDL TPKERENAIT KEFGAVFLIG
210 220 230 240 250
IGGVLPDGKP HDGRAPDYDD WTTETENGYH GLNGDILVWN DQLGSAFELS
260 270 280 290 300
SMGIRVDEEA LKRQVEMTGD QDRLGFDWHK SLLNGLFPLT IGGGIGQSRM
310 320 330
VMFLLRKQHI GEVQTSVWPQ EVRDSYDNIL
Length:330
Mass (Da):37,385
Last modified:June 1, 2001 - v1
Checksum:iB95B324CB73382D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA Translation: AAK34333.1
CP000017 Genomic DNA Translation: AAZ51887.1
RefSeqiNP_269612.1, NC_002737.2

Genome annotation databases

EnsemblBacteriaiAAK34333; AAK34333; SPy_1539
AAZ51887; AAZ51887; M5005_Spy1269
GeneIDi901583
KEGGispy:SPy_1539
spz:M5005_Spy1269
PATRICifig|160490.10.peg.1346

Similar proteinsi

Entry informationi

Entry nameiASNA_STRP1
AccessioniPrimary (citable) accession number: Q99YU0
Secondary accession number(s): Q48XN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health