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Q99YT1 (MSRAB_STRP1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA/MsrB

Including the following 2 domains:

  1. Peptide methionine sulfoxide reductase MsrA
    Short name=Protein-methionine-S-oxide reductase
    EC=1.8.4.11
    Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase
    Short name=Peptide Met(O) reductase
  2. Peptide methionine sulfoxide reductase MsrB
    EC=1.8.4.12
    Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase
Gene names
Name:msrAB
Synonyms:msrA
Ordered Locus Names:SPy_1557, M5005_Spy1282
OrganismStreptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]
Taxonomic identifier301447 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01400

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.

Sequence similarities

In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.

In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.

Sequence caution

The sequence AAK34345.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAZ51900.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Peptide methionine sulfoxide reductase MsrA/MsrB HAMAP MF_01400
PRO_0000138521

Regions

Region1 – 153153Peptide methionine sulfoxide reductase A HAMAP MF_01400
Region170 – 293124Peptide methionine sulfoxide reductase B HAMAP MF_01400

Sites

Active site81 By similarity
Active site2821 By similarity

Experimental info

Sequence conflict2941A → S in AAZ51900. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q99YT1 [UniParc].

Last modified May 2, 2002. Version 2.
Checksum: 226E1374F1038ADF

FASTA30935,103
        10         20         30         40         50         60 
MIYLAGGCFW GVEEYFSQVD GVLDAVSGYA NGRGDTTNYQ LIHQTGHAET VEVAYDANRI 

        70         80         90        100        110        120 
SLKELLLHFF RIIDPTSLNK QGNDRGSQYR TGIYYTDKAD LAIIDEVFKE KAKDYKKKIV 

       130        140        150        160        170        180 
VEKAPLKHFI KAEDYHQDYL KKNPNGYCHI DINQATYPVI DESKYPKPSA TEIKEKLSAD 

       190        200        210        220        230        240 
EYRVTQKNET EKAFSNRYWD SFDAGIYVDV VTGEPLFSSK DKFESGCGWP SFSRPISPDV 

       250        260        270        280        290        300 
VRYKEDKSFN MTRTEVRSRS GNSHLGHVFT DGPKDQGGLR YCINSLSITF IPKADMEAKG 


YGYLLSSVE

« Hide

References

[1]"Complete genome sequence of an M1 strain of Streptococcus pyogenes."
Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. expand/collapse author list , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E.
Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed: 11296296] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700294 / SF370 / Serotype M1.
[2]"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
J. Infect. Dis. 192:771-782(2005) [PubMed: 16088826] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004092 Genomic DNA. Translation: AAK34345.1. Different initiation.
CP000017 Genomic DNA. Translation: AAZ51900.1. Different initiation.
RefSeqNP_269624.1. NC_002737.1.
YP_282645.1. NC_007297.1.

3D structure databases

ProteinModelPortalQ99YT1.
SMRQ99YT1. Positions 2-159, 163-308.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000000434; EBSTRP00000000434; EBSTRG00000000434.
EBSTRT00000028881; EBSTRP00000027899; EBSTRG00000028881.
GeneID3571633.
901767.
GenomeReviewsGene locus SPy_1557 in contig AE004092_GR.
Gene locus M5005_Spy1282 in contig CP000017_GR.
KEGGspy:SPy_1557.
spz:M5005_Spy_1282.
PATRIC19716592. VBIStrPyo79812_1360.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000027538.
HOGENOMHBG715255.
OMAGIYYTDK.
ProtClustDBCLSK877225.

Enzyme and pathway databases

BioCycSPYO160490:SPY1557-MONOMER.
SPYO293653:M5005_SPY1282-MONOMER.

Family and domain databases

HAMAPMF_01400. MsrB. Fused.
[Tree]
MF_01401. MsrA. Fused.
[Tree]
InterProIPR002579. Methionine_sulphoxide_MsrB.
IPR011057. Mss4-like.
IPR002569. Peptide_Met_Sox_Rdtase_MsrA.
[Graphical view]
Gene3DG3DSA:3.30.1060.10. MsrA. 1 hit.
G3DSA:2.170.150.20. MsrB. 1 hit.
KOK12267.
PfamPF01625. PMSR. 1 hit.
PF01641. SelR. 1 hit.
[Graphical view]
SUPFAMSSF55068. MsrA. 1 hit.
SSF51316. Mss4_like. 1 hit.
TIGRFAMsTIGR00401. MsrA. 1 hit.
TIGR00357. TIGR00357. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRAB_STRP1
AccessionPrimary (citable) accession number: Q99YT1
Secondary accession number(s): Q48XM5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: January 25, 2012
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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