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Protein
Submitted name:

Uncharacterized protein

Gene

M5005_Spy1290

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1291-MONOMER.
SPYO293653:GHFC-1349-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:M5005_Spy1290Imported, SPy_1566Imported
OrganismiStreptococcus pyogenes serotype M1Imported
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750 Componenti: Chromosome UP000002702 Componenti: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VZHX-ray1.70A1-242[»]
ProteinModelPortaliQ99YS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000009708.
OMAiSIYWKPT.
OrthoDBiEOG68M4GS.

Family and domain databases

InterProiIPR021124. CRISPR-assoc_prot_Cas5.
IPR013422. CRISPR-assoc_prot_Cas5_N.
IPR010155. CRISPR-assoc_prot_Cas5d-typ.
[Graphical view]
PfamiPF09704. Cas_Cas5d. 1 hit.
[Graphical view]
PIRSFiPIRSF029950. Cas_CT1134. 1 hit.
TIGRFAMsiTIGR01876. cas_Cas5d. 1 hit.
TIGR02593. CRISPR_cas5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99YS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRSRDFYVR VSGQRALFTN PATKGGSERS SYSVPTRQAL NGIVDAIYYK
60 70 80 90 100
PTFTNIVTEV KVINQIQTEL QGVRALLHDY SADLSYVSYL SDVVYLIKFH
110 120 130 140 150
FVWNEDRKDL NSDRLPAKHE AIMERSIRKG GRRDVFLGTR ECLGLVDDIS
160 170 180 190 200
QEEYETTVSY YNGVNIDLGI MFHSFAYPKD KKTPLKSYFT KTVMKNGVIT
210 220 230 240
FKAQSECDIV NTLSSYAFKA PEEIKSVNDE CMEYDAMEKG EN
Length:242
Mass (Da):27,728
Last modified:June 1, 2001 - v1
Checksum:i55E499C60DB06098
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34353.1.
CP000017 Genomic DNA. Translation: AAZ51908.1.
RefSeqiNP_269632.1. NC_002737.1.
YP_282653.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34353; AAK34353; SPy_1566.
AAZ51908; AAZ51908; M5005_Spy1290.
GeneIDi3571603.
901815.
KEGGispy:SPy_1566.
spz:M5005_Spy_1290.
PATRICi19716608. VBIStrPyo79812_1368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34353.1.
CP000017 Genomic DNA. Translation: AAZ51908.1.
RefSeqiNP_269632.1. NC_002737.1.
YP_282653.1. NC_007297.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VZHX-ray1.70A1-242[»]
ProteinModelPortaliQ99YS3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK34353; AAK34353; SPy_1566.
AAZ51908; AAZ51908; M5005_Spy1290.
GeneIDi3571603.
901815.
KEGGispy:SPy_1566.
spz:M5005_Spy_1290.
PATRICi19716608. VBIStrPyo79812_1368.

Phylogenomic databases

HOGENOMiHOG000009708.
OMAiSIYWKPT.
OrthoDBiEOG68M4GS.

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1291-MONOMER.
SPYO293653:GHFC-1349-MONOMER.

Family and domain databases

InterProiIPR021124. CRISPR-assoc_prot_Cas5.
IPR013422. CRISPR-assoc_prot_Cas5_N.
IPR010155. CRISPR-assoc_prot_Cas5d-typ.
[Graphical view]
PfamiPF09704. Cas_Cas5d. 1 hit.
[Graphical view]
PIRSFiPIRSF029950. Cas_CT1134. 1 hit.
TIGRFAMsiTIGR01876. cas_Cas5d. 1 hit.
TIGR02593. CRISPR_cas5. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1Imported and SF370Imported.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported and MGAS5005Imported.
  3. "Conservation and variability in the structure and function of the Cas5d endoribonuclease in the CRISPR-mediated microbial immune system."
    Koo Y., Ka D., Kim E.J., Suh N., Bae E.
    J. Mol. Biol. 425:3799-3810(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MGAS5005.
  5. "Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences."
    Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W., Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D., Steinbakk M., Lowe D.E., McGeere A., Darenberg J., Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.
    Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2013)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SF370.

Entry informationi

Entry nameiQ99YS3_STRP1
AccessioniPrimary (citable) accession number: Q99YS3
Secondary accession number(s): Q48XL7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.