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Q99YP9

- Q99YP9_STRP1

UniProt

Q99YP9 - Q99YP9_STRP1

Protein
Submitted name:

Beta-glucosidase

Gene

M5005_Spy1313

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseImported, Hydrolase

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-1316-MONOMER.
    SPYO293653:GHFC-1373-MONOMER.

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Beta-glucosidaseImported (EC:3.2.1.21Imported)
    Submitted name:
    Putative beta-glucosidaseImported
    Gene namesi
    Ordered Locus Names:M5005_Spy1313Imported, SPy_1599Imported
    OrganismiStreptococcus pyogenes serotype M1Imported
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002702: Chromosome

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4B3KX-ray2.60A/B/C/D/E/F2-480[»]
    4B3LX-ray2.51A/B/C/D/E/F2-480[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000088632.
    KOiK05350.
    OMAiINEFIAQ.
    OrthoDBiEOG60658J.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001360. Glyco_hydro_1.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 1 hit.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99YP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAFPKEFWW GGATSGPQSE GRFAKQHRNL FDYWYEEEPD LFYDYVGPDT    50
    ASDAYHQIES DLTLLASLGH NSYRTSIQWT RLIDDFEQAT INPDGLAYYN 100
    RVIDACLANG IRPVINLHHF DLPIALYQAY GGWESKHVVD LFVAFSKVCF 150
    EQFGDRVKDW FVHNEPMVVV EGSYLMQFHY PAIVDGKKAV QVAYNLALAT 200
    AKVIQAYRRG PAELSDGRIG TILNLTPAYP ASQSEADMAA AHFAELWNND 250
    LFMEAAVHGK FPEELVAVLK KDGVLWQSTP EELALIAENR VDYLGLNFYH 300
    PKRVKAPDAI PVISPSWSPE WYYDPYLMPG RRMNVDKGWE IYPEAVYDIA 350
    IKMRDHYDNI PWFLSENGVG ISGEDRYRDE TGQIQDDYRI QFLKEHLTYL 400
    HKGIEAGSNC FGYHVWTPID GWSWLNAYKN RYGLVENNIH TQVRRPKASA 450
    YWFKKVATHN RLISLEVMEE FGGSASHLSD 480
    Length:480
    Mass (Da):55,111
    Last modified:June 1, 2001 - v1
    Checksum:iD25DB251F765E16F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34377.1.
    CP000017 Genomic DNA. Translation: AAZ51931.1.
    RefSeqiNP_269656.1. NC_002737.1.
    YP_282676.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK34377; AAK34377; SPy_1599.
    AAZ51931; AAZ51931; M5005_Spy1313.
    GeneIDi3571590.
    901846.
    KEGGispy:SPy_1599.
    spz:M5005_Spy_1313.
    PATRICi19716662. VBIStrPyo79812_1394.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34377.1 .
    CP000017 Genomic DNA. Translation: AAZ51931.1 .
    RefSeqi NP_269656.1. NC_002737.1.
    YP_282676.1. NC_007297.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4B3K X-ray 2.60 A/B/C/D/E/F 2-480 [» ]
    4B3L X-ray 2.51 A/B/C/D/E/F 2-480 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK34377 ; AAK34377 ; SPy_1599 .
    AAZ51931 ; AAZ51931 ; M5005_Spy1313 .
    GeneIDi 3571590.
    901846.
    KEGGi spy:SPy_1599.
    spz:M5005_Spy_1313.
    PATRICi 19716662. VBIStrPyo79812_1394.

    Phylogenomic databases

    HOGENOMi HOG000088632.
    KOi K05350.
    OMAi INEFIAQ.
    OrthoDBi EOG60658J.

    Enzyme and pathway databases

    BioCyci SPYO160490:GJ81-1316-MONOMER.
    SPYO293653:GHFC-1373-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001360. Glyco_hydro_1.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SF370Imported.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported and MGAS5005Imported.
    3. "Structure and activity of the Streptococcus pyogenes family GH1 6-phospho-?-glucosidase SPy1599."
      Stepper J., Dabin J., Eklof J.M., Thongpoo P., Kongsaeree P., Taylor E.J., Turkenburg J.P., Brumer H., Davies G.J.
      Acta Crystallogr. D 69:16-23(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 2-480.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MGAS5005.
    5. "Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences."
      Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W., Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D., Steinbakk M., Lowe D.E., McGeere A., Darenberg J., Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.
      Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2014)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SF370.

    Entry informationi

    Entry nameiQ99YP9_STRP1
    AccessioniPrimary (citable) accession number: Q99YP9
    Secondary accession number(s): Q48XJ4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3