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Q99YP9

- Q99YP9_STRP1

UniProt

Q99YP9 - Q99YP9_STRP1

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Protein
Submitted name:

Beta-glucosidase

Gene

M5005_Spy1313

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1316-MONOMER.
SPYO293653:GHFC-1373-MONOMER.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-glucosidaseImported (EC:3.2.1.21Imported)
Submitted name:
Putative beta-glucosidaseImported
Gene namesi
Ordered Locus Names:M5005_Spy1313Imported, SPy_1599Imported
OrganismiStreptococcus pyogenes serotype M1Imported
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B3KX-ray2.60A/B/C/D/E/F2-480[»]
4B3LX-ray2.51A/B/C/D/E/F2-480[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000088632.
KOiK05350.
OMAiINEFIAQ.
OrthoDBiEOG60658J.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99YP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAFPKEFWW GGATSGPQSE GRFAKQHRNL FDYWYEEEPD LFYDYVGPDT
60 70 80 90 100
ASDAYHQIES DLTLLASLGH NSYRTSIQWT RLIDDFEQAT INPDGLAYYN
110 120 130 140 150
RVIDACLANG IRPVINLHHF DLPIALYQAY GGWESKHVVD LFVAFSKVCF
160 170 180 190 200
EQFGDRVKDW FVHNEPMVVV EGSYLMQFHY PAIVDGKKAV QVAYNLALAT
210 220 230 240 250
AKVIQAYRRG PAELSDGRIG TILNLTPAYP ASQSEADMAA AHFAELWNND
260 270 280 290 300
LFMEAAVHGK FPEELVAVLK KDGVLWQSTP EELALIAENR VDYLGLNFYH
310 320 330 340 350
PKRVKAPDAI PVISPSWSPE WYYDPYLMPG RRMNVDKGWE IYPEAVYDIA
360 370 380 390 400
IKMRDHYDNI PWFLSENGVG ISGEDRYRDE TGQIQDDYRI QFLKEHLTYL
410 420 430 440 450
HKGIEAGSNC FGYHVWTPID GWSWLNAYKN RYGLVENNIH TQVRRPKASA
460 470 480
YWFKKVATHN RLISLEVMEE FGGSASHLSD
Length:480
Mass (Da):55,111
Last modified:June 1, 2001 - v1
Checksum:iD25DB251F765E16F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34377.1.
CP000017 Genomic DNA. Translation: AAZ51931.1.
RefSeqiNP_269656.1. NC_002737.1.
YP_282676.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34377; AAK34377; SPy_1599.
AAZ51931; AAZ51931; M5005_Spy1313.
GeneIDi3571590.
901846.
KEGGispy:SPy_1599.
spz:M5005_Spy_1313.
PATRICi19716662. VBIStrPyo79812_1394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34377.1 .
CP000017 Genomic DNA. Translation: AAZ51931.1 .
RefSeqi NP_269656.1. NC_002737.1.
YP_282676.1. NC_007297.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B3K X-ray 2.60 A/B/C/D/E/F 2-480 [» ]
4B3L X-ray 2.51 A/B/C/D/E/F 2-480 [» ]
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34377 ; AAK34377 ; SPy_1599 .
AAZ51931 ; AAZ51931 ; M5005_Spy1313 .
GeneIDi 3571590.
901846.
KEGGi spy:SPy_1599.
spz:M5005_Spy_1313.
PATRICi 19716662. VBIStrPyo79812_1394.

Phylogenomic databases

HOGENOMi HOG000088632.
KOi K05350.
OMAi INEFIAQ.
OrthoDBi EOG60658J.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-1316-MONOMER.
SPYO293653:GHFC-1373-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001360. Glyco_hydro_1.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1Imported and SF370Imported.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported and MGAS5005Imported.
  3. "Structure and activity of the Streptococcus pyogenes family GH1 6-phospho-?-glucosidase SPy1599."
    Stepper J., Dabin J., Eklof J.M., Thongpoo P., Kongsaeree P., Taylor E.J., Turkenburg J.P., Brumer H., Davies G.J.
    Acta Crystallogr. D 69:16-23(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 2-480.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MGAS5005.
  5. "Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences."
    Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W., Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D., Steinbakk M., Lowe D.E., McGeere A., Darenberg J., Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.
    Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2014)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SF370.

Entry informationi

Entry nameiQ99YP9_STRP1
AccessioniPrimary (citable) accession number: Q99YP9
Secondary accession number(s): Q48XJ4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3