Beta-glucosidase - Streptococcus pyogenes serotype M1

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Q99YP9 (Q99YP9_STRP1) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 67. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Beta-glucosidase EMBL AAZ51931.1
EC=3.2.1.21 EMBL AAZ51931.1

Submitted name:
Putative beta-glucosidase EMBL AAK34377.1

Gene names

Ordered Locus Names:

M5005_Spy1313, SPy_1599

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the glycosyl hydrolase 1 family. RuleBase RU003690

Ontologies

Keywords
Molecular function	Glycosidase EMBL AAZ51931.1 Hydrolase
Technical term	3D-structure PDB 4B3K PDB 4B3L Complete proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	beta-glucosidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q99YP9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D25DB251F765E16F
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480

55,111

        10         20         30         40         50         60 
MLAFPKEFWW GGATSGPQSE GRFAKQHRNL FDYWYEEEPD LFYDYVGPDT ASDAYHQIES 

        70         80         90        100        110        120 
DLTLLASLGH NSYRTSIQWT RLIDDFEQAT INPDGLAYYN RVIDACLANG IRPVINLHHF 

       130        140        150        160        170        180 
DLPIALYQAY GGWESKHVVD LFVAFSKVCF EQFGDRVKDW FVHNEPMVVV EGSYLMQFHY 

       190        200        210        220        230        240 
PAIVDGKKAV QVAYNLALAT AKVIQAYRRG PAELSDGRIG TILNLTPAYP ASQSEADMAA 

       250        260        270        280        290        300 
AHFAELWNND LFMEAAVHGK FPEELVAVLK KDGVLWQSTP EELALIAENR VDYLGLNFYH 

       310        320        330        340        350        360 
PKRVKAPDAI PVISPSWSPE WYYDPYLMPG RRMNVDKGWE IYPEAVYDIA IKMRDHYDNI 

       370        380        390        400        410        420 
PWFLSENGVG ISGEDRYRDE TGQIQDDYRI QFLKEHLTYL HKGIEAGSNC FGYHVWTPID 

       430        440        450        460        470        480 
GWSWLNAYKN RYGLVENNIH TQVRRPKASA YWFKKVATHN RLISLEVMEE FGGSASHLSD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. McLaughlin R.E. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.
[2]	"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.
[3]	"Structure and activity of the Streptococcus pyogenes family GH1 6-phospho-?-glucosidase SPy1599." Stepper J., Dabin J., Eklof J.M., Thongpoo P., Kongsaeree P., Taylor E.J., Turkenburg J.P., Brumer H., Davies G.J. Acta Crystallogr. D 69:16-23(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 2-480.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE004092 Genomic DNA. Translation: AAK34377.1.
CP000017 Genomic DNA. Translation: AAZ51931.1.

RefSeq

NP_269656.1. NC_002737.1.
YP_282676.1. NC_007297.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4B3K	X-ray	2.60	A/B/C/D/E/F	2-480	[»]
4B3L	X-ray	2.51	A/B/C/D/E/F	2-480	[»]

HSSP

HSSP built from PDB template 1PBG based on UniProtKB P11546.

ModBase

Protein family/group databases

CAZy

GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

EnsemblBacteria

AAK34377; AAK34377; SPy_1599.
AAZ51931; AAZ51931; M5005_Spy1313.

GeneID

3571590.
901846.

KEGG

spy:SPy_1599.
spz:M5005_Spy_1313.

PATRIC

19716662. VBIStrPyo79812_1394.

Organism-specific databases

CMR

Phylogenomic databases

HOGENOM

KO

OMA

ProtClustDB

Family and domain databases

Gene3D

3.20.20.80. 1 hit.

InterPro

IPR001360. Glyco_hydro_1.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]

PANTHER

PTHR10353. PTHR10353. 1 hit.

Pfam

PF00232. Glyco_hydro_1. 1 hit.
[Graphical view]

PRINTS

PR00131. GLHYDRLASE1.

SUPFAM

SSF51445. Glyco_hydro_cat. 1 hit.

ProtoNet

Entry information

Entry name

Q99YP9_STRP1

Accession

Primary (citable) accession number: Q99YP9
Secondary accession number(s): Q48XJ4

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info