Alpha-mannosidase - Streptococcus pyogenes serotype M1

Preferred order of sections

Names and origin

Protein names

Submitted name:
Alpha-mannosidase EMBL AAZ51935.1
EC=3.2.1.24 EMBL AAZ51935.1

Gene names

Ordered Locus Names:

M5005_Spy1317, SPy_1604

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

301447 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	901 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Metal-binding PDB 2WYI PDB 2WYH Zinc PDB 2WYI PDB 2WYH
Molecular function	Glycosidase EMBL AAZ51935.1 Hydrolase
Technical term	3D-structure PDB 2WYI PDB 2WYH Complete proteome
Gene Ontology (GO)
Biological process	mannose metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	alpha-mannosidase activity Inferred from electronic annotation. Source: EC carbohydrate binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

13

1

Zinc; via tele nitrogen PDB 2WYH

Metal binding

15

1

Zinc PDB 2WYH

Metal binding

125

1

Zinc PDB 2WYH

Metal binding

351

1

Zinc; via tele nitrogen PDB 2WYH

Sequences

Sequence

Length

Mass (Da)

Tools

Q99YP5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AB87B07001A83367
Show »

FASTA

901

102,751

        10         20         30         40         50         60 
MATKKVHIIS HSHWDREWYM AYEQHHMRLI NLIDDLLEVF QTDPDFHSFH LDGQTIILDD 

        70         80         90        100        110        120 
YLKVRPEREP EIRQAIASGK LRIGPFYILQ DDFLTSSESN VRNMLIGKED CDRWGASVPL 

       130        140        150        160        170        180 
GYFPDTFGNM GQTPQLMLKA GLQAAAFGRG IRPTGFNNQV DTSEKYSSQF SEISWQGPDN 

       190        200        210        220        230        240 
SRILGLLFAN WYSNGNEIPT TEAEARLFWD KKLADAERFA STKHLLMMNG CDHQPVQLDV 

       250        260        270        280        290        300 
TKAIALANQL YPDYEFVHSC FEDYLADLAD DLPENLSTVQ GEITSQETDG WYTLANTASA 

       310        320        330        340        350        360 
RIYLKQANTR VSRQLENITE PLAAMAYEVT STYPHDQLRY AWKTLMQNHP HDSICGCSVD 

       370        380        390        400        410        420 
SVHREMMTRF EKAYEVGHYL AKEAAKQIAD AIDTRDFPMD SQPFVLFNTS GHSKTSVAEL 

       430        440        450        460        470        480 
SLTWKKYHFG QRFPKEVYQE AQEYLARLSQ SFQIIDTSGQ VRPEAEILGT SIAFDYDLPK 

       490        500        510        520        530        540 
RSFREPYFAI KVRLRLPITL PAMSWKTLAL KLGNETTPSE TVSLYDDSNQ CLENGFLKVM 

       550        560        570        580        590        600 
IQTDGRLTIT DKQSGLIYQD LLRFEDCGDI GNEYISRQPN HDQPFYADQG TIKLNIISNT 

       610        620        630        640        650        660 
AQVAELEIQQ TFAIPISADK LLQAEMEAVI DITERQARRS QEKAELTLTT LIRMEKNNPR 

       670        680        690        700        710        720 
LQFTTRFDNQ MTNHRLRVLF PTHLKTDHHL ADSIFETVKR PNHPDATFWK NPSNPQHQEC 

       730        740        750        760        770        780 
FVSLFDGENG VTIGNYGLNE YEILPDTNTI AITLLRSVGE MGDWGYFPTP EAQCLGKHSL 

       790        800        810        820        830        840 
SYSFESITKQ TQFASYWRAQ EGQVPVITTQ TNQHEGTLAA EYSYLTGTND QVALTAFKRR 

       850        860        870        880        890        900 
LADNALITRS YNLSNDKTCD FSLSLPNYNA KVTNLLEKDS KQSTPSQLGK AEILTLAWKK 


Q

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. McLaughlin R. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed: 11296296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.
[2]	"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed: 16088826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.
[3]	"Structure and kinetic investigation of Streptococcus pyogenes family GH38 alpha-mannosidase." Suits M.D., Zhu Y., Taylor E.J., Walton J., Zechel D.L., Gilbert H.J., Davies G.J. PLoS ONE 5:e9006-e9006(2010) [PubMed: 20140249] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE004092 Genomic DNA. Translation: AAK34381.1.
CP000017 Genomic DNA. Translation: AAZ51935.1.

RefSeq

NP_269660.1. NC_002737.1.
YP_282680.1. NC_007297.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WYH	X-ray	1.90	A/B	1-901	[»]
2WYI	X-ray	2.60	A/B	1-901	[»]

ProteinModelPortal

Q99YP5.

ModBase

Search...

Protein family/group databases

CAZy

GH38. Glycoside Hydrolase Family 38.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBSTRT00000001415; EBSTRP00000001415; EBSTRG00000001415.
EBSTRT00000028644; EBSTRP00000027662; EBSTRG00000028644.

GeneID

3571594.
901852.

GenomeReviews

Gene locus M5005_Spy1317 in contig AE004092_GR.

PATRIC

19716670. VBIStrPyo79812_1398.

Organism-specific databases

CMR

Search...

Phylogenomic databases

GeneTree

EBGT00050000028884.

HOGENOM

HBG532911.

OMA

EPIFAEL.

ProtClustDB

CLSK872823.

Enzyme and pathway databases

BioCyc

SPYO160490:SPY1604-MONOMER.
SPYO293653:M5005_SPY1317-MONOMER.

Family and domain databases

InterPro

IPR011013. Glyco_hydro-type_carb-bd.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen_dom.
IPR000602. Glyco_hydro_38_core.
[Graphical view]

Gene3D

G3DSA:3.20.110.10. Glyco_hydro_38_core. 1 hit.

Pfam

PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]

SMART

SM00872. Alpha-mann_mid. 1 hit.
[Graphical view]

SUPFAM

SSF74650. Gal_mut_like. 1 hit.
SSF88713. Glyco_hydro/deAcase_b/a-brl. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q99YP5_STRP1

Accession

Primary (citable) accession number: Q99YP5
Secondary accession number(s): Q48XJ0

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)