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Q99YL1

- Q99YL1_STRP1

UniProt

Q99YL1 - Q99YL1_STRP1

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Protein
Submitted name:

Multimodular transpeptidase-transglycosylase

Gene

pbp1A

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. penicillin binding Source: InterPro
  2. peptidase activity Source: InterPro
  3. transferase activity, transferring pentosyl groups Source: InterPro

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: InterPro
  2. response to antibiotic Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1367-MONOMER.
SPYO293653:GHFC-1426-MONOMER.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Submitted name:
Multimodular transpeptidase-transglycosylaseImported
Submitted name:
Putative penicillin-binding protein 1aImported
Gene namesi
Name:pbp1AImported
Ordered Locus Names:M5005_Spy1355Imported, SPy_1649Imported
OrganismiStreptococcus pyogenes serotype M1Imported
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002702: Chromosome

Structurei

3D structure databases

ProteinModelPortaliQ99YL1.
SMRiQ99YL1. Positions 269-657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000041140.
KOiK05366.
OMAiMKTVLSY.
OrthoDBiEOG6CGCKC.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011816. PBP_1a.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.
TIGRFAMsiTIGR02074. PBP_1a_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99YL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITIKNPKIL KWLKYVLSAI LSLIILVIII GGLLFTFYIS SAPKLSEAQL
60 70 80 90 100
KSTNSSLVYD GNNNLIADLG SEKRENVTAD SIPINLVNAI TSIEDKRFFN
110 120 130 140 150
HRGVDLYRIF GAAFHNLTSQ TTQGGSTLDQ QLIKLAYFST NESDQTLKRK
160 170 180 190 200
AQEVWLALQM ERKYTKQEIL TFYINKVYMG NGNYGMLTAA KSYYGKDLKD
210 220 230 240 250
LSYAQLALLA GIPQAPSQYD PYLHPEAAQN RRNVVLQQMY MEKHLTKAEY
260 270 280 290 300
ETAIATPVAE GLQSLQQRST YPKYMDNYLK QVIEEVKKET NKDIFTAGLK
310 320 330 340 350
VYTNIIPDAQ QTLYNIYHSG DYVYYPDQDF QVASTIVDVT NGHVIAQLGG
360 370 380 390 400
RNQDENVSFG TNQAVLTDRD WGSTMKPITA YAPAIESGVY TSTAQSTNDS
410 420 430 440 450
VYYWPGTTTQ LFNWDLRYNG WMTIQAAIML SRNVPAVRAL EAAGLDYARS
460 470 480 490 500
FLSSLGINYP EMHYSNAISS NNSSSDKKYG ASSEKMAAAY AAFANGGIYH
510 520 530 540 550
KPRYVNKVEF SDGTSKTFDE KGKRAMKETT AYMMTDMLKT VLTYGTGTAA
560 570 580 590 600
AIPGVAQAGK TGTSNYTDEE LAKIGEKYGL YPDYVGTLAP DENFVGFTKR
610 620 630 640 650
YAMAVWTGYK NRLTPVYGSS LEIASDVYRS MMTYLTNGYS EDWTMPNGLY
660 670 680 690 700
RSGGFLYLSG TYASNTDYTN SVYNNLYSNN TTTASSQTTS DDTSSSNDTS
710 720
NSTNTDNNGS HPSTDDKKTT H
Length:721
Mass (Da):80,208
Last modified:June 1, 2001 - v1
Checksum:i7E9350705EF4C6D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34416.1.
CP000017 Genomic DNA. Translation: AAZ51973.1.
RefSeqiNP_269695.1. NC_002737.1.
YP_282718.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34416; AAK34416; SPy_1649.
AAZ51973; AAZ51973; M5005_Spy1355.
GeneIDi3571548.
901903.
KEGGispy:SPy_1649.
spz:M5005_Spy_1355.
PATRICi19716770. VBIStrPyo79812_1437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34416.1 .
CP000017 Genomic DNA. Translation: AAZ51973.1 .
RefSeqi NP_269695.1. NC_002737.1.
YP_282718.1. NC_007297.1.

3D structure databases

ProteinModelPortali Q99YL1.
SMRi Q99YL1. Positions 269-657.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34416 ; AAK34416 ; SPy_1649 .
AAZ51973 ; AAZ51973 ; M5005_Spy1355 .
GeneIDi 3571548.
901903.
KEGGi spy:SPy_1649.
spz:M5005_Spy_1355.
PATRICi 19716770. VBIStrPyo79812_1437.

Phylogenomic databases

HOGENOMi HOG000041140.
KOi K05366.
OMAi MKTVLSY.
OrthoDBi EOG6CGCKC.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-1367-MONOMER.
SPYO293653:GHFC-1426-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011816. PBP_1a.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.
TIGRFAMsi TIGR02074. PBP_1a_fam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SF370Imported.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported and MGAS5005Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MGAS5005.
  4. "Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences."
    Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W., Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D., Steinbakk M., Lowe D.E., McGeere A., Darenberg J., Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.
    Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2014)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SF370.

Entry informationi

Entry nameiQ99YL1_STRP1
AccessioniPrimary (citable) accession number: Q99YL1
Secondary accession number(s): Q48XF2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3