Q99YL1 (Q99YL1_STRP1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Multimodular transpeptidase-transglycosylase EMBL AAZ51973.1

Submitted name:
Putative penicillin-binding protein 1a EMBL AAK34416.1

Gene names

Name:	pbp1A EMBL AAK34416.1
Ordered Locus Names:	M5005_Spy1355, SPy_1649

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

301447 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes

Protein attributes

Sequence length	721 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidoglycan biosynthetic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: InterPro
Cellular_component	peptidoglycan-based cell wall Inferred from electronic annotation. Source: InterPro
Molecular_function	penicillin binding Inferred from electronic annotation. Source: InterPro peptidase activity Inferred from electronic annotation. Source: InterPro transferase activity, transferring pentosyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q99YL1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7E9350705EF4C6D0	FASTA	721	80,208
	10 20 30 40 50 60 MITIKNPKIL KWLKYVLSAI LSLIILVIII GGLLFTFYIS SAPKLSEAQL KSTNSSLVYD 70 80 90 100 110 120 GNNNLIADLG SEKRENVTAD SIPINLVNAI TSIEDKRFFN HRGVDLYRIF GAAFHNLTSQ 130 140 150 160 170 180 TTQGGSTLDQ QLIKLAYFST NESDQTLKRK AQEVWLALQM ERKYTKQEIL TFYINKVYMG 190 200 210 220 230 240 NGNYGMLTAA KSYYGKDLKD LSYAQLALLA GIPQAPSQYD PYLHPEAAQN RRNVVLQQMY 250 260 270 280 290 300 MEKHLTKAEY ETAIATPVAE GLQSLQQRST YPKYMDNYLK QVIEEVKKET NKDIFTAGLK 310 320 330 340 350 360 VYTNIIPDAQ QTLYNIYHSG DYVYYPDQDF QVASTIVDVT NGHVIAQLGG RNQDENVSFG 370 380 390 400 410 420 TNQAVLTDRD WGSTMKPITA YAPAIESGVY TSTAQSTNDS VYYWPGTTTQ LFNWDLRYNG 430 440 450 460 470 480 WMTIQAAIML SRNVPAVRAL EAAGLDYARS FLSSLGINYP EMHYSNAISS NNSSSDKKYG 490 500 510 520 530 540 ASSEKMAAAY AAFANGGIYH KPRYVNKVEF SDGTSKTFDE KGKRAMKETT AYMMTDMLKT 550 560 570 580 590 600 VLTYGTGTAA AIPGVAQAGK TGTSNYTDEE LAKIGEKYGL YPDYVGTLAP DENFVGFTKR 610 620 630 640 650 660 YAMAVWTGYK NRLTPVYGSS LEIASDVYRS MMTYLTNGYS EDWTMPNGLY RSGGFLYLSG 670 680 690 700 710 720 TYASNTDYTN SVYNNLYSNN TTTASSQTTS DDTSSSNDTS NSTNTDNNGS HPSTDDKKTT H

References

[1]

"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.

[2]

"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004092 Genomic DNA. Translation: AAK34416.1. CP000017 Genomic DNA. Translation: AAZ51973.1.
RefSeq	NP_269695.1. NC_002737.1. YP_282718.1. NC_007297.1.
3D structure databases
SMR	Q99YL1. Positions 269-657.
ModBase	Search...
Protein family/group databases
CAZy	GT51. Glycosyltransferase Family 51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK34416; AAK34416; SPy_1649. AAZ51973; AAZ51973; M5005_Spy1355.
GeneID	3571548. 901903.
KEGG	spy:SPy_1649. spz:M5005_Spy_1355.
PATRIC	19716770. VBIStrPyo79812_1437.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000041140.
KO	K05366.
OMA	NQEPSAS.
ProtClustDB	CLSK877241.
Family and domain databases
Gene3D	3.40.710.10. 1 hit.
InterPro	IPR012338. Beta-lactam/transpept-like. IPR001264. Glyco_trans_51. IPR011816. PBP_1a. IPR001460. PCN-bd_Tpept. [Graphical view]
Pfam	PF00912. Transgly. 1 hit. PF00905. Transpeptidase. 1 hit. [Graphical view]
SUPFAM	SSF56601. PBP_transp_fold. 1 hit.
TIGRFAMs	TIGR02074. PBP_1a_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q99YL1_STRP1

Accession

Primary (citable) accession number: Q99YL1
Secondary accession number(s): Q48XF2

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)