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Q99YL1

- Q99YL1_STRP1

UniProt

Q99YL1 - Q99YL1_STRP1

Protein
Submitted name:

Multimodular transpeptidase-transglycosylase

Gene

pbp1A

Organism
Streptococcus pyogenes serotype M1
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. penicillin binding Source: InterPro
    2. peptidase activity Source: InterPro
    3. transferase activity, transferring pentosyl groups Source: InterPro

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: InterPro
    2. response to antibiotic Source: InterPro

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-1367-MONOMER.
    SPYO293653:GHFC-1426-MONOMER.

    Protein family/group databases

    CAZyiGT51. Glycosyltransferase Family 51.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Multimodular transpeptidase-transglycosylaseImported
    Submitted name:
    Putative penicillin-binding protein 1aImported
    Gene namesi
    Name:pbp1AImported
    Ordered Locus Names:M5005_Spy1355Imported, SPy_1649Imported
    OrganismiStreptococcus pyogenes serotype M1Imported
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002702: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliQ99YL1.
    SMRiQ99YL1. Positions 269-657.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000041140.
    KOiK05366.
    OMAiMKTVLSY.
    OrthoDBiEOG6CGCKC.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR001264. Glyco_trans_51.
    IPR023346. Lysozyme-like_dom.
    IPR011816. PBP_1a.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF00912. Transgly. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    SSF56601. SSF56601. 2 hits.
    TIGRFAMsiTIGR02074. PBP_1a_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99YL1-1 [UniParc]FASTAAdd to Basket

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    MITIKNPKIL KWLKYVLSAI LSLIILVIII GGLLFTFYIS SAPKLSEAQL    50
    KSTNSSLVYD GNNNLIADLG SEKRENVTAD SIPINLVNAI TSIEDKRFFN 100
    HRGVDLYRIF GAAFHNLTSQ TTQGGSTLDQ QLIKLAYFST NESDQTLKRK 150
    AQEVWLALQM ERKYTKQEIL TFYINKVYMG NGNYGMLTAA KSYYGKDLKD 200
    LSYAQLALLA GIPQAPSQYD PYLHPEAAQN RRNVVLQQMY MEKHLTKAEY 250
    ETAIATPVAE GLQSLQQRST YPKYMDNYLK QVIEEVKKET NKDIFTAGLK 300
    VYTNIIPDAQ QTLYNIYHSG DYVYYPDQDF QVASTIVDVT NGHVIAQLGG 350
    RNQDENVSFG TNQAVLTDRD WGSTMKPITA YAPAIESGVY TSTAQSTNDS 400
    VYYWPGTTTQ LFNWDLRYNG WMTIQAAIML SRNVPAVRAL EAAGLDYARS 450
    FLSSLGINYP EMHYSNAISS NNSSSDKKYG ASSEKMAAAY AAFANGGIYH 500
    KPRYVNKVEF SDGTSKTFDE KGKRAMKETT AYMMTDMLKT VLTYGTGTAA 550
    AIPGVAQAGK TGTSNYTDEE LAKIGEKYGL YPDYVGTLAP DENFVGFTKR 600
    YAMAVWTGYK NRLTPVYGSS LEIASDVYRS MMTYLTNGYS EDWTMPNGLY 650
    RSGGFLYLSG TYASNTDYTN SVYNNLYSNN TTTASSQTTS DDTSSSNDTS 700
    NSTNTDNNGS HPSTDDKKTT H 721
    Length:721
    Mass (Da):80,208
    Last modified:June 1, 2001 - v1
    Checksum:i7E9350705EF4C6D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34416.1.
    CP000017 Genomic DNA. Translation: AAZ51973.1.
    RefSeqiNP_269695.1. NC_002737.1.
    YP_282718.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK34416; AAK34416; SPy_1649.
    AAZ51973; AAZ51973; M5005_Spy1355.
    GeneIDi3571548.
    901903.
    KEGGispy:SPy_1649.
    spz:M5005_Spy_1355.
    PATRICi19716770. VBIStrPyo79812_1437.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34416.1 .
    CP000017 Genomic DNA. Translation: AAZ51973.1 .
    RefSeqi NP_269695.1. NC_002737.1.
    YP_282718.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali Q99YL1.
    SMRi Q99YL1. Positions 269-657.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT51. Glycosyltransferase Family 51.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK34416 ; AAK34416 ; SPy_1649 .
    AAZ51973 ; AAZ51973 ; M5005_Spy1355 .
    GeneIDi 3571548.
    901903.
    KEGGi spy:SPy_1649.
    spz:M5005_Spy_1355.
    PATRICi 19716770. VBIStrPyo79812_1437.

    Phylogenomic databases

    HOGENOMi HOG000041140.
    KOi K05366.
    OMAi MKTVLSY.
    OrthoDBi EOG6CGCKC.

    Enzyme and pathway databases

    BioCyci SPYO160490:GJ81-1367-MONOMER.
    SPYO293653:GHFC-1426-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR001264. Glyco_trans_51.
    IPR023346. Lysozyme-like_dom.
    IPR011816. PBP_1a.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF00912. Transgly. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    SSF56601. SSF56601. 2 hits.
    TIGRFAMsi TIGR02074. PBP_1a_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SF370Imported.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1Imported and MGAS5005Imported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MGAS5005.
    4. "Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences."
      Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W., Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D., Steinbakk M., Lowe D.E., McGeere A., Darenberg J., Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.
      Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2014)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SF370.

    Entry informationi

    Entry nameiQ99YL1_STRP1
    AccessioniPrimary (citable) accession number: Q99YL1
    Secondary accession number(s): Q48XF2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3