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Protein

Alanine racemase

Gene

alr

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Active sitei263Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei310Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:SPy_1802, M5005_Spy1532
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001145831 – 366Alanine racemaseAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ99Y98

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_1802

Structurei

3D structure databases

ProteinModelPortaliQ99Y98
SMRiQ99Y98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q99Y98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSFHRPTV ARVNLQAIKE NVASVQKHIP LGVKTYAVVK ADAYGHGAVQ
60 70 80 90 100
VSKALLPQVD GYCVSNLDEA LQLRQAGIDK EILILGVLLP NELELAVANA
110 120 130 140 150
ITVTIASLDW IALARLEKKE CQGLKVHVKV DSGMGRIGLR SSKEVNLLID
160 170 180 190 200
SLKELGADVE GIFTHFATAD EADDTKFNQQ LQFFKKLIAG LEDKPRLVHA
210 220 230 240 250
SNSATSIWHS DTIFNAVRLG IVSYGLNPSG SDLSLPFPLQ EALSLESSLV
260 270 280 290 300
HVKMISAGDT VGYGATYTAK KSEYVGTVPI GYADGWTRNM QGFSVLVDGQ
310 320 330 340 350
FCEIIGRVSM DQLTIRLPKA YPLGTKVTLI GSNQQKNIST TDIANYRNTI
360
NYEVLCLLSD RIPRIY
Length:366
Mass (Da):39,901
Last modified:June 1, 2001 - v1
Checksum:iA4C5174370AF9B95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA Translation: AAK34532.1
CP000017 Genomic DNA Translation: AAZ52150.1
RefSeqiNP_269811.1, NC_002737.2

Genome annotation databases

EnsemblBacteriaiAAK34532; AAK34532; SPy_1802
AAZ52150; AAZ52150; M5005_Spy1532
GeneIDi902028
KEGGispy:SPy_1802
spz:M5005_Spy1532
PATRICifig|160490.10.peg.1568

Similar proteinsi

Entry informationi

Entry nameiALR_STRP1
AccessioniPrimary (citable) accession number: Q99Y98
Secondary accession number(s): Q48WX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health