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Q99XR2

- FTHS2_STRP1

UniProt

Q99XR2 - FTHS2_STRP1

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Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1703-MONOMER.
SPYO293653:GHFC-1855-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 2UniRule annotation
Short name:
FHS 2UniRule annotation
Short name:
FTHFS 2UniRule annotation
Gene namesi
Name:fhs2UniRule annotation
Synonyms:fhs.2
Ordered Locus Names:SPy_2085, M5005_Spy1774
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligase 2PRO_0000199390Add
BLAST

Proteomic databases

PaxDbiQ99XR2.

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_2085.

Structurei

3D structure databases

ProteinModelPortaliQ99XR2.
SMRiQ99XR2. Positions 5-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiQLRYIND.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99XR2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLSDIEIAN SVTMEPISKV ADQLGIDKEA LCLYGKYKAK IDARQLVALK
60 70 80 90 100
NKPDGKLILV TAISPTPAGE GKTTTSVGLV DALSAIGKKA VIALREPSLG
110 120 130 140 150
PVFGVKGGAA GGGHAQVVPM EDINLHFTGD FHAIGVANNL LAALIDNHIH
160 170 180 190 200
HGNSLGIDSR RITWKRVVDM NDRQLRHIVD GLQGKVNGIP REDGYDITVA
210 220 230 240 250
SEIMAILCLS ENISDLKARL EKIIIGYNYQ GEPVTAKDLK AGGALAALLK
260 270 280 290 300
DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYGDYAVTEA
310 320 330 340 350
GFGADLGAEK FIDIKCRMSG LRPAAVVLVA TIRALKMHGG VPKADLATEN
360 370 380 390 400
VQAVVDGLPN LDKHLANIQD VYGLPVVVAI NKFPLDTDAE LQAVYDACDK
410 420 430 440 450
RGVDVVISDV WANGGAGGRE LAEKVVTLAE QDNQFRFVYE EDDSIETKLT
460 470 480 490 500
KIVTKVYGGK GINLSSAAKR ELADLERLGF GNYPICMAKT QYSFSDDAKK
510 520 530 540 550
LGAPTDFTVT ISNLKVSAGA GFIVALTGAI MTMPGLPKVP ASETIDIDEE

GNITGLF
Length:557
Mass (Da):59,054
Last modified:June 1, 2001 - v1
Checksum:iCB07C9FCE90B34E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34738.1.
CP000017 Genomic DNA. Translation: AAZ52392.1.
RefSeqiNP_270017.1. NC_002737.1.
YP_283137.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34738; AAK34738; SPy_2085.
AAZ52392; AAZ52392; M5005_Spy1774.
GeneIDi3571100.
901726.
KEGGispy:SPy_2085.
spz:M5005_Spy_1774.
PATRICi19717527. VBIStrPyo79812_1807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34738.1 .
CP000017 Genomic DNA. Translation: AAZ52392.1 .
RefSeqi NP_270017.1. NC_002737.1.
YP_283137.1. NC_007297.1.

3D structure databases

ProteinModelPortali Q99XR2.
SMRi Q99XR2. Positions 5-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_2085.

Proteomic databases

PaxDbi Q99XR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34738 ; AAK34738 ; SPy_2085 .
AAZ52392 ; AAZ52392 ; M5005_Spy1774 .
GeneIDi 3571100.
901726.
KEGGi spy:SPy_2085.
spz:M5005_Spy_1774.
PATRICi 19717527. VBIStrPyo79812_1807.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi QLRYIND.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SPYO160490:GJ81-1703-MONOMER.
SPYO293653:GHFC-1855-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiFTHS2_STRP1
AccessioniPrimary (citable) accession number: Q99XR2
Secondary accession number(s): Q48W83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3