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Q99XH4

- SYW_STRP1

UniProt

Q99XH4 - SYW_STRP1

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei205 – 2051ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-1801-MONOMER.
    SPYO293653:GHFC-1939-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Synonyms:trsA
    Ordered Locus Names:SPy_2207, M5005_Spy1858
    OrganismiStreptococcus pyogenes serotype M1
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Tryptophan--tRNA ligasePRO_0000136692Add
    BLAST

    Proteomic databases

    PaxDbiQ99XH4.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi160490.SPy_2207.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99XH4.
    SMRiQ99XH4. Positions 2-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 209"HIGH" region
    Motifi202 – 2065"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000059941.
    KOiK01867.
    OMAiVFTHSAV.
    OrthoDBiEOG686NJQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99XH4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKPIILTGD RPTGKLHLGH YVGSLKNRVF LQNENKYKMF VFLADQQALT    50
    DHAKESELIQ ESIGNVALDY LSVGLDPKQS TIFIQSQIPE LAELSMYYMN 100
    LVSLARLERN PTVKTEIAQK GFGESIPSGF LVYPVSQAAD ITAFKANLVP 150
    VGNDQKPMIE QTREIVRSFN HTYHTDCLVE PEGIYPENEK AGRLPGLDGN 200
    AKMSKSLGNG IYLSDDADTV RKKVMSMYTD PNHIKIEDPG QIEGNMVFHY 250
    LDIFARKEDQ ADIEAMKEHY QIGGLGDVKT KRYLLDILER ELAPIRERRL 300
    EYAKDMGEVF RMLQEGSQKA RTVAAKTLSE VKSAMGINYF 340
    Length:340
    Mass (Da):38,330
    Last modified:June 1, 2001 - v1
    Checksum:i3FAFE2E1F4312143
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34835.1.
    CP000017 Genomic DNA. Translation: AAZ52476.1.
    RefSeqiNP_270114.1. NC_002737.1.
    YP_283221.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK34835; AAK34835; SPy_2207.
    AAZ52476; AAZ52476; M5005_Spy1858.
    GeneIDi3571030.
    901899.
    KEGGispy:SPy_2207.
    spz:M5005_Spy_1858.
    PATRICi19717737. VBIStrPyo79812_1912.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34835.1 .
    CP000017 Genomic DNA. Translation: AAZ52476.1 .
    RefSeqi NP_270114.1. NC_002737.1.
    YP_283221.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali Q99XH4.
    SMRi Q99XH4. Positions 2-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160490.SPy_2207.

    Proteomic databases

    PaxDbi Q99XH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK34835 ; AAK34835 ; SPy_2207 .
    AAZ52476 ; AAZ52476 ; M5005_Spy1858 .
    GeneIDi 3571030.
    901899.
    KEGGi spy:SPy_2207.
    spz:M5005_Spy_1858.
    PATRICi 19717737. VBIStrPyo79812_1912.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000059941.
    KOi K01867.
    OMAi VFTHSAV.
    OrthoDBi EOG686NJQ.

    Enzyme and pathway databases

    BioCyci SPYO160490:GJ81-1801-MONOMER.
    SPYO293653:GHFC-1939-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700294 / SF370 / Serotype M1.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

    Entry informationi

    Entry nameiSYW_STRP1
    AccessioniPrimary (citable) accession number: Q99XH4
    Secondary accession number(s): Q48VZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3