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Q99X42

- Q99X42_STAAM

UniProt

Q99X42 - Q99X42_STAAM

Protein
Submitted name:

Similar to surfactin synthetase

Gene

SAV0179

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. catalytic activity Source: InterPro

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-179-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Similar to surfactin synthetaseImported
    Gene namesi
    Ordered Locus Names:SAV0179Imported
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)Imported
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    PTM / Processingi

    Keywords - PTMi

    PhosphopantetheineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV0179.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4F6CX-ray2.81A/B2010-2391[»]
    4F6LX-ray3.86A/B1929-2391[»]
    ProteinModelPortaliQ99X42.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG3320.
    HOGENOMiHOG000279727.
    OMAiDADSNPK.
    OrthoDBiEOG6XHC08.
    PhylomeDBiQ99X42.

    Family and domain databases

    Gene3Di1.10.1200.10. 2 hits.
    3.40.50.720. 1 hit.
    InterProiIPR010071. AA_adenyl_domain.
    IPR009081. Acyl_carrier_prot-like.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR001242. Condensatn.
    IPR013120. Male_sterile_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR006162. PPantetheine_attach_site.
    IPR010080. Thioester_reductase-like_dom.
    [Graphical view]
    PfamiPF00501. AMP-binding. 2 hits.
    PF13193. AMP-binding_C. 2 hits.
    PF00668. Condensation. 2 hits.
    PF07993. NAD_binding_4. 1 hit.
    PF00550. PP-binding. 2 hits.
    [Graphical view]
    SUPFAMiSSF47336. SSF47336. 2 hits.
    TIGRFAMsiTIGR01733. AA-adenyl-dom. 2 hits.
    TIGR01746. Thioester-redct. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 2 hits.
    PS00455. AMP_BINDING. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99X42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMGNLRFQQ EYFRIYKNNT ESTTHRNAYW VKLAKNVEAT KMMYALSTIV     50
    QQHASIRHFF DVTTDDNLTM ILHEFLPFIE IKQVPSSSAN YDLEAFFKQE 100
    LSTYHFNDSP LFKVKLFQFA DAAYILLDFH VSIFDDSQID IFLDDLCNAY 150
    RGNTVINNTR QHAHINRNDD KDNQDASHIA LDSNYFRLEN NSDIHIDSYF 200
    PIKHPFEQAL YQTYLIDDMT SIDMASLAVS VYLANHIMSQ QHDVTLGIHV 250
    PSHLPNDLHG NIVPLTLTID AKDVCQRFTT DFNKCVLQNM SQLQCAKSSL 300
    SLETIFHCYH HMMSCCNDVI EDVHQIHDAH TSLADIEIFP HQHGFKIIYN 350
    SAAYDLLSIE TLSDLVRNIY LQITEENGNK RTTVDELNLM TERDIQLYDD 400
    INLSLPEIDD AQTVVTLFEQ QVEATPNHVA VQFDGVFITY QTLNARANDL 450
    AHRLRNQYGV EPNDRVAVIA EKSIEMIIAM IGVLKAGGAY VPIDPNYPSD 500
    RQEYILKDAT PKVVITYQAL YENGKQNINH IDLNKIAWKN IDNLSKCNTL 550
    EDHAYVIYTS GTTGNPKGTL IPHRGIVRLV HRNHYVPLNE ETTILLSGTI 600
    AFDAATFEIY GALLNGGKLI VAKKEQLLNP IAVEQLINEN DVNTMWLTSS 650
    LFNQIASERI EVLVPLKYLL IGGEVLNAKW VDLLNQKPKH PQIINGYGPT 700
    ENTTFTTTYN IPNKVPNRIP IGKPILGTHV YIMQGERRCG VGIPGELCTS 750
    GFGLAAGYLN QPELTADKFI KDSNINQLMY RSGDIVRLLP DGNIDYLYRK 800
    DKQVKIRGFR IELSEVEHAL ERIQGINKAV VIVQNHDQDQ YIVAYYEAMH 850
    TLSHNKIKSQ LRMTLPEYMI PVNFMHIEQI PITINGKLDK KALPIMDYVD 900
    TDAYVAPSTD TEHLLCQIFA DILHVNQVGI HDNFFELGGH SLKATLVVNR 950
    IEASTGKRLQ IGDLLQKPTV FELAQAIAKV QEQNYEVIPE AIVKDDYVLS 1000
    SAQKRMYLLW KSNHKDTVYN VPFLWRLSSG LNVAQLQQAV QHLIARHEIL 1050
    RTQYIVVDDE VRQRIVADVV ADFEEVNTHF TDEQEIMRQF VAPFNLEKPS 1100
    QIRVRYIRSP LHAYLFIDTH HIINDGMSNI QLMNDLNALY QHKLLLPLKL 1150
    QYKDYSEWMS HRDMTKHRQY WLSQFKDEVP ILSLPTDYVR PNIKTTNGAM 1200
    MSFTMNQQMR QLLQKYVEKH QITDFMFFMS VVMTLLSRYA RKDDVVVGSV 1250
    MSARMHKGTE QMLGMFANTL VYRGQPSPDK MWTQFLQEVK EMSLEAYEHQ 1300
    EYPFECLVND LDQSHDASRN PLFDVMLVLQ NNETNHAHFG HSKLTHIQPK 1350
    SVTAKFDLSF IIEEDRDDYT INIEYNTDLY HSETVRHMGN QCMIMIDYIL 1400
    KHQDTLQICD IPNGTEELLN WVNTHVNDRM LNVPGNKSII SYFNEVVSRQ 1450
    GNHVALVMND LTMTYETLRN YVDAIAHMLL SNGVGNGQRV ALFTERSFEM 1500
    IAAMLATVKV GASYIPIDID FPNKRQGAIL EDAKVTAVMS YGVEIETTLP 1550
    VIQLENAKGF VESKENEQYD DLHGNQLENT AMLDNEMYAI YTSGTTGMPK 1600
    GVAIRQRNLL NLVHAWSTEL QLGDNEVFLQ HANIVFDASV MEIYCCLLNG 1650
    HTLVIPDREE RVNPEQLQQL INKHRVTVAS IPLQMCSIME DFYIEKLITG 1700
    GATSTASFVK YIEKHCGTYF NAYGPSESTV ITSYWSHHCG DLIPETIPIG 1750
    KPLSNIQVYI MSDGLLCGIG MPGELCIAGD SLAIGYINRP ELMADKWQNN 1800
    PFGKGKLYHS GDLARYTSDG QIEFLGRIDK QVKVNGYRIE LDEIENVILA 1850
    IRGISDCVVT VSHFDTHDIL NAYYVGEQQV EQDLKQYLND QLPKYMIPKT 1900
    ITHIDCMPLT TNDKVDTTRL PNPSPIQQSN KVYSEPSNEI EQTFVDVFGE 1950
    VLKQNDVGVD DDFFELGGNS LEAMLVVSHL KRFGHHISMQ TLYQYKTVRQ 2000
    IVNYMYQNQQ SLVALPDNLS ELQKIVMSRY NLGILEDSLS HRPLGNTLLT 2050
    GATGFLGAYL IEALQGYSHR IYCFIRADNE EIAWYKLMTN LNDYFSEETV 2100
    EMMLSNIEVI VGDFECMDDV VLPENMDTII HAGARTDHFG DDDEFEKVNV 2150
    QGTVDVIRLA QQHHARLIYV STISVGTYFD IDTEDVTFSE ADVYKGQLLT 2200
    SPYTRSKFYS ELKVLEAVNN GLDGRIVRVG NLTSPYNGRW HMRNIKTNRF 2250
    SMVMNDLLQL DCIGVSMAEM PVDFSFVDTT ARQIVALAQV NTPQIIYHVL 2300
    SPNKMPVKSL LECVKRKEIE LVSDESFNEI LQKQDMYETI GLTSVDREQQ 2350
    LAMIDTTLTL KIMNHISEKW PTITNNWLYH WAQYIKTIFN K 2391
    Length:2,391
    Mass (Da):273,338
    Last modified:June 1, 2001 - v1
    Checksum:i13A3A2C5D9298AC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB56341.1.
    PIRiG89779.
    RefSeqiNP_370703.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB56341; BAB56341; SAV0179.
    GeneIDi1120138.
    KEGGisav:SAV0179.
    PATRICi19560965. VBIStaAur52173_0180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB56341.1 .
    PIRi G89779.
    RefSeqi NP_370703.1. NC_002758.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4F6C X-ray 2.81 A/B 2010-2391 [» ]
    4F6L X-ray 3.86 A/B 1929-2391 [» ]
    ProteinModelPortali Q99X42.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV0179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB56341 ; BAB56341 ; SAV0179 .
    GeneIDi 1120138.
    KEGGi sav:SAV0179.
    PATRICi 19560965. VBIStaAur52173_0180.

    Phylogenomic databases

    eggNOGi COG3320.
    HOGENOMi HOG000279727.
    OMAi DADSNPK.
    OrthoDBi EOG6XHC08.
    PhylomeDBi Q99X42.

    Enzyme and pathway databases

    BioCyci SAUR158878:GJJ5-179-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1200.10. 2 hits.
    3.40.50.720. 1 hit.
    InterProi IPR010071. AA_adenyl_domain.
    IPR009081. Acyl_carrier_prot-like.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR001242. Condensatn.
    IPR013120. Male_sterile_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR006162. PPantetheine_attach_site.
    IPR010080. Thioester_reductase-like_dom.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 2 hits.
    PF13193. AMP-binding_C. 2 hits.
    PF00668. Condensation. 2 hits.
    PF07993. NAD_binding_4. 1 hit.
    PF00550. PP-binding. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47336. SSF47336. 2 hits.
    TIGRFAMsi TIGR01733. AA-adenyl-dom. 2 hits.
    TIGR01746. Thioester-redct. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 2 hits.
    PS00455. AMP_BINDING. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699Imported.
    2. "Heterologous expression and structural characterisation of a pyrazinone natural product assembly line."
      Wyatt M.A., Mok M.C., Junop M., Magarvey N.A.
      ChemBioChem 13:2408-2415(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 2010-2391.

    Entry informationi

    Entry nameiQ99X42_STAAM
    AccessioniPrimary (citable) accession number: Q99X42
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3