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Protein

Glycyl-glycine endopeptidase LytM

Gene

lytM

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase (autolysin) specifically acting on polyglycine interpeptide bridges of the cell wall peptidoglycan.By similarity

Catalytic activityi

Hydrolysis of the -Gly-|-Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171ZincBy similarity
Metal bindingi210 – 2101ZincBy similarity
Metal bindingi214 – 2141ZincBy similarity
Metal bindingi293 – 2931ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Cell wall biogenesis/degradation, Virulence

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-277-MONOMER.

Protein family/group databases

MEROPSiM23.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycyl-glycine endopeptidase LytM (EC:3.4.24.75)
Alternative name(s):
Autolysin LytM
Gene namesi
Name:lytM
Ordered Locus Names:SAV0276
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 316291Glycyl-glycine endopeptidase LytMPRO_0000026821Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiQ99WV0.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi158878.SAV0276.

Structurei

3D structure databases

ProteinModelPortaliQ99WV0.
SMRiQ99WV0. Positions 45-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M23B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DR5. Bacteria.
COG0739. LUCA.
COG3942. LUCA.
HOGENOMiHOG000279753.
KOiK08259.
OMAiGNGKINY.

Family and domain databases

InterProiIPR011055. Dup_hybrid_motif.
IPR016047. Peptidase_M23.
[Graphical view]
PfamiPF01551. Peptidase_M23. 1 hit.
[Graphical view]
SUPFAMiSSF51261. SSF51261. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99WV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLTAAAIA TMGFATFTMA HQADAAETTN TQQAHTLMST QSQDVSYGTY
60 70 80 90 100
YTIDSNGDYH HTPDGNWNQA MFDNKEYSYT FVDAQGHTHY FYNCYPKNAN
110 120 130 140 150
ANGSGQTYVN PATAGDNNDY TASQSQQHIN QYGYQSNVGP DASYYSHSNN
160 170 180 190 200
NQAYNSHDGN GKVNYPNGTS NQNGGSASKA TASGHAKDAS WLTSRKQLQP
210 220 230 240 250
YGQYHGGGAH YGVDYAMPEN SPVYSLTDGT VVQAGWSNYG GGNQVTIKEA
260 270 280 290 300
NSNNYQWYMH NNRLTVSAGD KVKAGDQIAY SGSTGNSTAP HVHFQRMSGG
310
IGNQYAVDPT SYLQSR
Length:316
Mass (Da):34,302
Last modified:June 1, 2001 - v1
Checksum:iB2914E862691DC0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56438.1.
RefSeqiWP_000736784.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56438; BAB56438; SAV0276.
KEGGisav:SAV0276.
PATRICi19561166. VBIStaAur52173_0280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56438.1.
RefSeqiWP_000736784.1. NC_002758.2.

3D structure databases

ProteinModelPortaliQ99WV0.
SMRiQ99WV0. Positions 45-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0276.

Protein family/group databases

MEROPSiM23.013.

Proteomic databases

PaxDbiQ99WV0.

Protocols and materials databases

DNASUi1120234.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56438; BAB56438; SAV0276.
KEGGisav:SAV0276.
PATRICi19561166. VBIStaAur52173_0280.

Phylogenomic databases

eggNOGiENOG4105DR5. Bacteria.
COG0739. LUCA.
COG3942. LUCA.
HOGENOMiHOG000279753.
KOiK08259.
OMAiGNGKINY.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-277-MONOMER.

Family and domain databases

InterProiIPR011055. Dup_hybrid_motif.
IPR016047. Peptidase_M23.
[Graphical view]
PfamiPF01551. Peptidase_M23. 1 hit.
[Graphical view]
SUPFAMiSSF51261. SSF51261. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLYTM_STAAM
AccessioniPrimary (citable) accession number: Q99WV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.