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Protein

Lipase 2

Gene

lip2

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei413NucleophileBy similarity1
Metal bindingi580Calcium; via carbonyl oxygenBy similarity1
Active sitei604Charge relay systemPROSITE-ProRule annotation1
Metal bindingi645CalciumBy similarity1
Active sitei646Charge relay systemPROSITE-ProRule annotation1
Metal bindingi648CalciumBy similarity1
Metal bindingi653CalciumBy similarity1
Metal bindingi656CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

ESTHERistaau-lipas. Bacterial_lip_FamI.6.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase 2 (EC:3.1.1.3)
Alternative name(s):
Glycerol ester hydrolase 2
Gene namesi
Name:lip2
Synonyms:geh
Ordered Locus Names:SAV0320
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
PropeptideiPRO_000004518838 – 296By similarityAdd BLAST259
ChainiPRO_0000045189297 – 691Lipase 2Add BLAST395

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiQ99WQ6.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0320.

Structurei

3D structure databases

ProteinModelPortaliQ99WQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105J1V. Bacteria.
COG1075. LUCA.
HOGENOMiHOG000279776.
KOiK01046.
OMAiAERNESQ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99WQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGQEERKY SIRKYSIGVV SVLAATMFVV SSHEAQASEK TPTSNAAAQK
60 70 80 90 100
ETLNQPGEQG NAITSHQMQS GKQLDDMHKE NGKSGTVTEG KDTLQSSKHQ
110 120 130 140 150
STQNSKTIRT QNDNQVKQDS ERQGSKQSHQ NNATNNTERQ NDQVQNTHHA
160 170 180 190 200
ERNGSQSTTS QSNDVDKSQP SIPAQKVLPN HDKAAPTSTT PPSNDKTAPK
210 220 230 240 250
STKAQDATTD KHPNQQDTHQ PAHQIIDAKQ DDTVRQSEQK PQVGDLSKHI
260 270 280 290 300
DGQNSPEKPT DKNTDNKQLI KDALQAPKTR STTNAAADAK KVRPLKANQV
310 320 330 340 350
QPLNKYPVVF VHGFLGLVGD NAPALYPNYW GGNKFKVIEE LRKQGYNVHQ
360 370 380 390 400
ASVSAFGSNY DRAVELYYYI KGGRVDYGAA HAAKYGHERY GKTYKGIMPN
410 420 430 440 450
WEPGKKVHLV GHSMGGQTIR LMEEFLRNGN KEEIAYHKAH GGEISPLFTG
460 470 480 490 500
GHNNMVASIT TLATPHNGSQ AADKFGNTEA VRKIMFALNR FMGNKYSNID
510 520 530 540 550
LGLTQWGFKQ LPNESYIDYI KRVSKSKIWT SDDNAAYDLT LDGSAKLNNM
560 570 580 590 600
TSMNPNITYT TYTGVSSHTG PLGYENPDLG TFFLMDTTSR IIGHDAREEW
610 620 630 640 650
RKNDGVVPVI SSLHPSNQPF INVTNDEPAT RRGIWQVKPI IQGWDHVDFI
660 670 680 690
GVDFLDFKRK GAELANFYTG IINDLLRVEA TESKGTQLKA S
Length:691
Mass (Da):76,543
Last modified:June 1, 2001 - v1
Checksum:i11F2117D26C54C7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56482.1.
RefSeqiWP_000943819.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56482; BAB56482; SAV0320.
KEGGisav:SAV0320.
PATRICi19561252. VBIStaAur52173_0323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56482.1.
RefSeqiWP_000943819.1. NC_002758.2.

3D structure databases

ProteinModelPortaliQ99WQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0320.

Protein family/group databases

ESTHERistaau-lipas. Bacterial_lip_FamI.6.

Proteomic databases

PaxDbiQ99WQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56482; BAB56482; SAV0320.
KEGGisav:SAV0320.
PATRICi19561252. VBIStaAur52173_0323.

Phylogenomic databases

eggNOGiENOG4105J1V. Bacteria.
COG1075. LUCA.
HOGENOMiHOG000279776.
KOiK01046.
OMAiAERNESQ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIP2_STAAM
AccessioniPrimary (citable) accession number: Q99WQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.