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Q99WM3 (THLA_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable acetyl-CoA acyltransferase
EC=2.3.1.9
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene names
Ordered Locus Names:SAV0354
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the thiolase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacetyl-CoA C-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Probable acetyl-CoA acyltransferase
PRO_0000270504

Sites

Active site881Acyl-thioester intermediate By similarity
Active site3491Proton acceptor By similarity
Active site3781Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99WM3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: EA0563681A298EFB

FASTA39341,753
        10         20         30         40         50         60 
MTRVVLAAAY RTPIGVFGGA FKDVPAYDLG ATLIEHIIKE TGLNPSEIDE VIIGNVLQAG 

        70         80         90        100        110        120 
QGQNPARIAA MKGGLPETVP AFTVNKVCGS GLKSIQLAYQ SIVTGENDIV LAGGMENMSQ 

       130        140        150        160        170        180 
SPMLVNNSRF GFKMGHQSMV DSMVYDGLTD VFNQYHMGIT AENLVEQYGI SREEQDTFAV 

       190        200        210        220        230        240 
NSQHKAVRAQ QNGEFDSEIV PVSIPQRKGE PILVTKDEGV RENVSVEKLS RLRPAFKKDG 

       250        260        270        280        290        300 
TVTAGNASGI NDGAAMMLVM SEDKAKELNI EPLAVLDGFG SHGVDPSIMG IAPVGAVEKA 

       310        320        330        340        350        360 
LKRSKKELSD IDVFELNEAF AAQLLAVDRE LKLPPEKVNV KGGAIALGHP IGASGARVLV 

       370        380        390 
TLLHQLNDEV ETGLTSLCIG GGQAIAAVVS KYK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000017 Genomic DNA. Translation: BAB56516.1.
RefSeqNP_370878.1. NC_002758.2.

3D structure databases

HSSPHSSP built from PDB template 1WL4 based on UniProtKB Q9BWD1.
ProteinModelPortalQ99WM3.
SMRQ99WM3. Positions 4-390.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ99WM3.

2D gel databases

World-2DPAGE0002:Q99WM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000005839; EBSTAP00000005657; EBSTAG00000005838.
GeneID1120311.
GenomeReviewsGene locus SAV0354 in contig BA000017_GR.
KEGGsav:SAV0354.
PATRIC19561322. VBIStaAur52173_0358.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0183.
GeneTreeEBGT00050000024085.
HOGENOMHBG370930.
OMANPSEINE.
PhylomeDBQ99WM3.
ProtClustDBCLSK884583.

Enzyme and pathway databases

BioCycSAUR158878:SAV0354-MONOMER.

Family and domain databases

InterProIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 4 hits.
KOK00626.
PANTHERPTHR18919. Thiolase. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHLA_STAAM
AccessionPrimary (citable) accession number: Q99WM3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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