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Protein

Xanthine phosphoribosyltransferase

Gene

xpt

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (xpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei27 – 271XanthineUniRule annotation
Binding sitei156 – 1561XanthineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-389-MONOMER.
UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Short name:
XPRTaseUniRule annotation
Gene namesi
Name:xptUniRule annotation
Ordered Locus Names:SAV0388
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Xanthine phosphoribosyltransferasePRO_0000339748Add
BLAST

Proteomic databases

PaxDbiQ99WJ1.
PRIDEiQ99WJ1.

2D gel databases

World-2DPAGE0002:Q99WJ1.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi158878.SAV0388.

Structurei

3D structure databases

ProteinModelPortaliQ99WJ1.
SMRiQ99WJ1. Positions 1-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 13255-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UPS. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000036777.
KOiK03816.
OMAiHQIDPEL.
OrthoDBiEOG6GTZNX.
PhylomeDBiQ99WJ1.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99WJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLGQKVKE DGVVIDEKIL KVDGFLNHQI DAKLMNEVGR TFYEQFKDKG
60 70 80 90 100
ITKILTIEAS GIAPAIMAAL HFDVPCLFAK KAKPSTLTDG YYETSIHSFT
110 120 130 140 150
KNKTSTVIVS KEFLSEEDTV LIIDDFLANG DASLGLYDIA QQANAKTAGI
160 170 180 190
GIVVEKSFQN GHQRLEEAGL TVSSLCKVAS LEGNKVTLVG EE
Length:192
Mass (Da):20,884
Last modified:June 1, 2001 - v1
Checksum:i8E56855976C6BEC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56550.1.
RefSeqiWP_000421410.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56550; BAB56550; SAV0388.
KEGGisav:SAV0388.
PATRICi19561394. VBIStaAur52173_0394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56550.1.
RefSeqiWP_000421410.1. NC_002758.2.

3D structure databases

ProteinModelPortaliQ99WJ1.
SMRiQ99WJ1. Positions 1-191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0388.

2D gel databases

World-2DPAGE0002:Q99WJ1.

Proteomic databases

PaxDbiQ99WJ1.
PRIDEiQ99WJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56550; BAB56550; SAV0388.
KEGGisav:SAV0388.
PATRICi19561394. VBIStaAur52173_0394.

Phylogenomic databases

eggNOGiENOG4108UPS. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000036777.
KOiK03816.
OMAiHQIDPEL.
OrthoDBiEOG6GTZNX.
PhylomeDBiQ99WJ1.

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658.
BioCyciSAUR158878:GJJ5-389-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiXPT_STAAM
AccessioniPrimary (citable) accession number: Q99WJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.