Q99W78 (CLPC_STAAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpC

Gene names

Name:	clpC
Ordered Locus Names:	SAV0525

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	818 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP By similarity.
Sequence similarities	Belongs to the clpA/clpB family. ClpC subfamily. Contains 1 UVR domain.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein metabolic process Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 818	818	ATP-dependent Clp protease ATP-binding subunit ClpC		PRO_0000269683
Regions
	Domain	417 – 452	36	UVR
	Nucleotide binding	208 – 215	8	ATP Potential
	Nucleotide binding	545 – 552	8	ATP Potential
	Region	163 – 410	248	I
	Region	471 – 662	192	II

Sequences

	Sequence		Length	Mass (Da)
	Q99W78 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 404DBB1643BAA31F	FASTA	818	91,037
	10 20 30 40 50 60 MLFGRLTERA QRVLAHAQEE AIRLNHSNIG TEHLLLGLMK EPEGIAAKVL ESFNITEDKV 70 80 90 100 110 120 IEEVEKLIGH GQDHVGTLHY TPRAKKVIEL SMDEARKLHH NFVGTEHILL GLIRENEGVA 130 140 150 160 170 180 ARVFANLDLN ITKARAQVVK ALGNPEMSNK NAQASKSNNT PTLDSLARDL TVIAKDGTLD 190 200 210 220 230 240 PVIGRDKEIT RVIEVLSRRT KNNPVLIGEP GVGKTAIAEG LAQAIVNNEV PETLKDKRVM 250 260 270 280 290 300 SLDMGTVVAG TKYRGEFEER LKKVMEEIQQ AGNVILFIDE LHTLVGAGGA EGAIDASNIL 310 320 330 340 350 360 KPALARGELQ CIGATTLDEY RKNIEKDAAL ERRFQPVQVD EPSVVDTVAI LKGLRDRYEA 370 380 390 400 410 420 HHRINISDEA IEAAVKLSNR YVSDRFLPDK AIDLIDEASS KVRLKSHTTP NNLKEIEQEI 430 440 450 460 470 480 EKVKNEKDAA VHAQEFENAA NLRDKQTKLE KQYEEAKNEW KNAQNGMSTS LSEEDIAEVI 490 500 510 520 530 540 AGWTGIPLTK INETESEKLL SLEDTLHERV IGQKDAVNSI SKAVRRARAG LKDPKRPIGS 550 560 570 580 590 600 FIFLGPTGVG KTELARALAE SMFGDDDAMI RVDMSEFMEK HAVSRLVGAP PGYVGHDDGG 610 620 630 640 650 660 QLTEKVRRKP YSVILFDEIE KAHPDVFNIL LQVLDDGHLT DTKGRTVDFR NTIIIMTSNV 670 680 690 700 710 720 GAQELQDQRF AGFGGSSDGQ DYETIRKTML KELKNSFRPE FLNRVDDIIV FHKLTKEELK 730 740 750 760 770 780 EIVTMMVNKL TNRLSEQNIN IIVTDKAKDK IAEEGYDPEY GARPLIRAIQ KTIEDNLSEL 790 800 810 ILDGNQIEGK KVTVDHDGKE FKYDIAEQTS ETKTPSQA

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu50 / ATCC 700699.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000017 Genomic DNA. Translation: BAB56687.1.
RefSeq	NP_371049.1. NC_002758.2.
3D structure databases
HSSP	HSSP built from PDB template 1JBK based on UniProtKB P63284.
ProteinModelPortal	Q99W78.
SMR	Q99W78. Positions 2-801.
ModBase	Search...
Protein-protein interaction databases
STRING	158878.SAV0525.
2D gel databases
World-2DPAGE	0002:Q99W78.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB56687; BAB56687; SAV0525.
GeneID	1120498.
KEGG	sav:SAV0525.
PATRIC	19561700. VBIStaAur52173_0530.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0542.
HOGENOM	HOG000218210.
KO	K03696.
OMA	FHQLTRD.
ProtClustDB	CLSK2460849.
Enzyme and pathway databases
BioCyc	SAUR158878:GJJ5-542-MONOMER.
Family and domain databases
Gene3D	1.10.1780.10. 1 hit.
InterPro	IPR003593. AAA+_ATPase. IPR013093. ATPase_AAA-2. IPR003959. ATPase_AAA_core. IPR018368. Chaperonin_ClpA/B_CS. IPR001270. Chaprnin_ClpA/B. IPR019489. Clp_ATPase_C. IPR004176. Clp_N. IPR023150. Dbl_Clp-N. IPR001943. UVR_dom. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF07724. AAA_2. 1 hit. PF02861. Clp_N. 2 hits. PF10431. ClpB_D2-small. 1 hit. PF02151. UVR. 1 hit. [Graphical view]
PRINTS	PR00300. CLPPROTEASEA.
SMART	SM00382. AAA. 2 hits. SM01086. ClpB_D2-small. 1 hit. [Graphical view]
PROSITE	PS00870. CLPAB_1. 1 hit. PS00871. CLPAB_2. 1 hit. PS50151. UVR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPC_STAAM

Accession

Primary (citable) accession number: Q99W78

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program