Q99W72 (TRMHL_STAAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative TrmH family tRNA/rRNA methyltransferase
EC=2.1.1.-

Gene names

Ordered Locus Names:

SAV0531

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the RNA methyltransferase TrmH family.

Ontologies

Keywords
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro RNA methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Putative TrmH family tRNA/rRNA methyltransferase		PRO_0000224828
Sites
	Binding site	196	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	216	1	S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	225	1	S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q99W72 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 8DFB9C9777F95543	FASTA	248	27,181
	10 20 30 40 50 60 MEDTVIVGRH AVREAIITGH PINKILIQEG IKKQQINEIL KNAKDQKIIV QTVPKSKLDF 70 80 90 100 110 120 LANAPHQGVA ALIAPYEYAD FDQFLKQQKE KEGLSTVLIL DGLEDPHNLG SILRTADATG 130 140 150 160 170 180 VDGVIIPKRR SVTLTQTVAK ASTGAIEHVP VIRVTNLAKT IDELKDNGFW VAGTEANNAT 190 200 210 220 230 240 DYRNLEADMS LAIVIGSEGQ GMSRLVSDKC DFYIKIPMVG HVNSLNASVA ASLMMYEVFR KRHDVGEI

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu50 / ATCC 700699.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000017 Genomic DNA. Translation: BAB56693.1.
RefSeq	NP_371055.1. NC_002758.2.
3D structure databases
ProteinModelPortal	Q99W72.
ModBase	Search...
Protein-protein interaction databases
STRING	Q99W72.
2D gel databases
World-2DPAGE	0002:Q99W72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000007259; EBSTAP00000007077; EBSTAG00000007258.
GeneID	1120504.
GenomeReviews	Gene locus SAV0531 in contig BA000017_GR.
KEGG	sav:SAV0531.
PATRIC	19561714. VBIStaAur52173_0537.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0566.
GeneTree	EBGT00050000024953.
HOGENOM	HBG714057.
OMA	AVEYVPV.
PhylomeDB	Q99W72.
ProtClustDB	CLSK884713.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV0531-MONOMER.
Family and domain databases
InterPro	IPR004441. rRNA_MeTrfase_TrmH. IPR001537. SpoU_MeTrfase. IPR013123. SpoU_subst-bd. [Graphical view]
KO	K03218.
Pfam	PF00588. SpoU_methylase. 1 hit. PF08032. SpoU_sub_bind. 1 hit. [Graphical view]
SMART	SM00967. SpoU_sub_bind. 1 hit. [Graphical view]
TIGRFAMs	TIGR00186. RRNA_methyl_3. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRMHL_STAAM

Accession

Primary (citable) accession number: Q99W72

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program