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Protein

Putative long chain fatty acid-CoA ligase VraA

Gene

vraA

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-593-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative long chain fatty acid-CoA ligase VraA (EC:6.2.1.-)
Alternative name(s):
Acyl-CoA synthetase
Gene namesi
Name:vraA
Ordered Locus Names:SAV0575
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Putative long chain fatty acid-CoA ligase VraAPRO_0000193192Add
BLAST

Proteomic databases

PaxDbiQ99W34.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0575.

Structurei

3D structure databases

ProteinModelPortaliQ99W34.
SMRiQ99W34. Positions 8-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107F3J. Bacteria.
COG0318. LUCA.
HOGENOMiHOG000279836.
OMAiWFESVCK.
PhylomeDBiQ99W34.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99W34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVILEQLKT HTQNKPNDIA LHIDDETITY SQLNARITSA VESLQKYSLN
60 70 80 90 100
PVVAINMKSP VQSIICYLAL HRLHKVPMMM EGKWQSTIHR QLIEKYGIKD
110 120 130 140 150
VIGDTGLMQN IDSPMFIDST QLQHYPNLLH IGFTSGTTGL PKAYYRDEDS
160 170 180 190 200
WLASFEVNEM LMLKNENAIA APGPLSHSLT LYALLFALSS GRTFIGQTTF
210 220 230 240 250
HPEKLLNQCH KISSYKVAMF LVPTMIKSLL LVYNNEHTIQ SFFSSGDKLH
260 270 280 290 300
SSIFKKIKNQ ANDINLIEFF GTSETSFISY NLNQQAPVES VGVLFPNVEL
310 320 330 340 350
KTTNHDHNGI GTICIKSNMM FSGYVSEQCI NNDEWFVTND NGYVKEQYLY
360 370 380 390 400
LTGRQQDMLI IGGQNIYPAH VERLLTQSSS IDEAIIIGIP NERFGQIGVL
410 420 430 440 450
LYSGDVTLTH KNVKQFLKKK VKRYEIPSMI HHVEKMYYTA SGKIAREKMM

SMYLRGEL
Length:458
Mass (Da):52,024
Last modified:June 1, 2001 - v1
Checksum:i0843B823F1F5267B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56737.1.
RefSeqiWP_001100835.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56737; BAB56737; SAV0575.
KEGGisav:SAV0575.
PATRICi19561802. VBIStaAur52173_0581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56737.1.
RefSeqiWP_001100835.1. NC_002758.2.

3D structure databases

ProteinModelPortaliQ99W34.
SMRiQ99W34. Positions 8-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0575.

Proteomic databases

PaxDbiQ99W34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56737; BAB56737; SAV0575.
KEGGisav:SAV0575.
PATRICi19561802. VBIStaAur52173_0581.

Phylogenomic databases

eggNOGiENOG4107F3J. Bacteria.
COG0318. LUCA.
HOGENOMiHOG000279836.
OMAiWFESVCK.
PhylomeDBiQ99W34.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-593-MONOMER.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVRAA_STAAM
AccessioniPrimary (citable) accession number: Q99W34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

May contribute to vancomycin resistance.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.