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Q99W31

- Q99W31_STAAM

UniProt

Q99W31 - Q99W31_STAAM

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Protein
Submitted name:

Phosphomethylpyrimidine kinase

Gene

SAV0580

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391ADPImported
Binding sitei204 – 2041ADP; via amide nitrogen and carbonyl oxygenImported
Binding sitei204 – 2041ATPanalog; via amide nitrogen and carbonyl oxygenImported
Binding sitei209 – 2091ADPImported
Binding sitei238 – 2381ADPImported
Binding sitei238 – 2381ATPanalogImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi176 – 1805ADPImported
Nucleotide bindingi176 – 1794ATPanalogImported
Nucleotide bindingi186 – 1883ADPImported
Nucleotide bindingi186 – 1883ATPanalogImported
Nucleotide bindingi209 – 2146ATPanalogImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphomethylpyrimidine kinase activity Source: InterPro

GO - Biological processi

  1. thiamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-598-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphomethylpyrimidine kinaseImported
Gene namesi
Ordered Locus Names:SAV0580Imported
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)Imported
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

PTM / Processingi

2D gel databases

World-2DPAGE0002:Q99W31.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0580.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C5JX-ray1.45A/B/C/D2-276[»]
4C5KX-ray1.40A/B/C/D2-276[»]
4C5LX-ray1.85A/B/C/D2-276[»]
4C5MX-ray1.45A/B/C/D2-276[»]
ProteinModelPortaliQ99W31.
SMRiQ99W31. Positions 2-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0351.
HOGENOMiHOG000225273.
KOiK00868.
OMAiHTHGAGD.
OrthoDBiEOG6XWV53.
PhylomeDBiQ99W31.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99W31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALKKVLTIA GSDTSAGAGM QADLKTFQEL DTYGMVALTA IVTMDKDTWS
60 70 80 90 100
HDVTPLPMDV FEKQLETALS IGPDAIKTGM LGTEEIIKRA GEVYEASNAQ
110 120 130 140 150
YFVVDPVMVC KGEDEVLNPG NTEAMIKYLL PKATVVTPNL FEAGQLSGLG
160 170 180 190 200
KLNSIEDMKK AATIIFDKGA QHVIIKGGKA LDQDKSYDLY YDGQTFYQLT
210 220 230 240 250
TDMFQQSYNH GAGCTFAAAT TAYLANGKSP KEAVISAKAF VASAIKNGWK
260 270
MNDFVGPVDH GAYNRIEHID VEVTEV
Length:276
Mass (Da):29,857
Last modified:June 1, 2001 - v1
Checksum:i62C5F054E4D56779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56742.1.
PIRiF89826.
RefSeqiNP_371104.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56742; BAB56742; SAV0580.
GeneIDi1120553.
KEGGisav:SAV0580.
PATRICi19561812. VBIStaAur52173_0586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56742.1 .
PIRi F89826.
RefSeqi NP_371104.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4C5J X-ray 1.45 A/B/C/D 2-276 [» ]
4C5K X-ray 1.40 A/B/C/D 2-276 [» ]
4C5L X-ray 1.85 A/B/C/D 2-276 [» ]
4C5M X-ray 1.45 A/B/C/D 2-276 [» ]
ProteinModelPortali Q99W31.
SMRi Q99W31. Positions 2-276.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158878.SAV0580.

2D gel databases

World-2DPAGE 0002:Q99W31.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB56742 ; BAB56742 ; SAV0580 .
GeneIDi 1120553.
KEGGi sav:SAV0580.
PATRICi 19561812. VBIStaAur52173_0586.

Phylogenomic databases

eggNOGi COG0351.
HOGENOMi HOG000225273.
KOi K00868.
OMAi HTHGAGD.
OrthoDBi EOG6XWV53.
PhylomeDBi Q99W31.

Enzyme and pathway databases

BioCyci SAUR158878:GJJ5-598-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699Imported.
  2. "A subfamily of bacterial ribokinases utilizes a hemithioacetal for pyridoxal phosphate salvage."
    Nodwell M.B., Koch M.F., Alte F., Schneider S., Sieber S.A.
    J. Am. Chem. Soc. 136:4992-4999(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 2-276 IN COMPLEX WITH ADP AND ATPANALOG.

Entry informationi

Entry nameiQ99W31_STAAM
AccessioniPrimary (citable) accession number: Q99W31
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3