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Q99W31

- Q99W31_STAAM

UniProt

Q99W31 - Q99W31_STAAM

Protein
Submitted name:

Phosphomethylpyrimidine kinase

Gene

SAV0580

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei139 – 1391ADPImported
    Binding sitei204 – 2041ADP; via amide nitrogen and carbonyl oxygenImported
    Binding sitei204 – 2041ATPanalog; via amide nitrogen and carbonyl oxygenImported
    Binding sitei209 – 2091ADPImported
    Binding sitei238 – 2381ADPImported
    Binding sitei238 – 2381ATPanalogImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi176 – 1805ADPImported
    Nucleotide bindingi176 – 1794ATPanalogImported
    Nucleotide bindingi186 – 1883ADPImported
    Nucleotide bindingi186 – 1883ATPanalogImported
    Nucleotide bindingi209 – 2146ATPanalogImported

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphomethylpyrimidine kinase activity Source: InterPro

    GO - Biological processi

    1. thiamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    KinaseSAAS annotationImported, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-598-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Phosphomethylpyrimidine kinaseImported
    Gene namesi
    Ordered Locus Names:SAV0580Imported
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)Imported
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    PTM / Processingi

    2D gel databases

    World-2DPAGE0002:Q99W31.

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV0580.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4C5JX-ray1.45A/B/C/D2-276[»]
    4C5KX-ray1.40A/B/C/D2-276[»]
    4C5LX-ray1.85A/B/C/D2-276[»]
    4C5MX-ray1.45A/B/C/D2-276[»]
    ProteinModelPortaliQ99W31.
    SMRiQ99W31. Positions 2-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0351.
    HOGENOMiHOG000225273.
    KOiK00868.
    OMAiHTHGAGD.
    OrthoDBiEOG6XWV53.
    PhylomeDBiQ99W31.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    InterProiIPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF08543. Phos_pyr_kin. 1 hit.
    [Graphical view]
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99W31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKKVLTIA GSDTSAGAGM QADLKTFQEL DTYGMVALTA IVTMDKDTWS    50
    HDVTPLPMDV FEKQLETALS IGPDAIKTGM LGTEEIIKRA GEVYEASNAQ 100
    YFVVDPVMVC KGEDEVLNPG NTEAMIKYLL PKATVVTPNL FEAGQLSGLG 150
    KLNSIEDMKK AATIIFDKGA QHVIIKGGKA LDQDKSYDLY YDGQTFYQLT 200
    TDMFQQSYNH GAGCTFAAAT TAYLANGKSP KEAVISAKAF VASAIKNGWK 250
    MNDFVGPVDH GAYNRIEHID VEVTEV 276
    Length:276
    Mass (Da):29,857
    Last modified:June 1, 2001 - v1
    Checksum:i62C5F054E4D56779
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB56742.1.
    PIRiF89826.
    RefSeqiNP_371104.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB56742; BAB56742; SAV0580.
    GeneIDi1120553.
    KEGGisav:SAV0580.
    PATRICi19561812. VBIStaAur52173_0586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB56742.1 .
    PIRi F89826.
    RefSeqi NP_371104.1. NC_002758.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4C5J X-ray 1.45 A/B/C/D 2-276 [» ]
    4C5K X-ray 1.40 A/B/C/D 2-276 [» ]
    4C5L X-ray 1.85 A/B/C/D 2-276 [» ]
    4C5M X-ray 1.45 A/B/C/D 2-276 [» ]
    ProteinModelPortali Q99W31.
    SMRi Q99W31. Positions 2-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV0580.

    2D gel databases

    World-2DPAGE 0002:Q99W31.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB56742 ; BAB56742 ; SAV0580 .
    GeneIDi 1120553.
    KEGGi sav:SAV0580.
    PATRICi 19561812. VBIStaAur52173_0586.

    Phylogenomic databases

    eggNOGi COG0351.
    HOGENOMi HOG000225273.
    KOi K00868.
    OMAi HTHGAGD.
    OrthoDBi EOG6XWV53.
    PhylomeDBi Q99W31.

    Enzyme and pathway databases

    BioCyci SAUR158878:GJJ5-598-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    InterProi IPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF08543. Phos_pyr_kin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699Imported.
    2. "A subfamily of bacterial ribokinases utilizes a hemithioacetal for pyridoxal phosphate salvage."
      Nodwell M.B., Koch M.F., Alte F., Schneider S., Sieber S.A.
      J. Am. Chem. Soc. 136:4992-4999(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 2-276 IN COMPLEX WITH ADP AND ATPANALOG.

    Entry informationi

    Entry nameiQ99W31_STAAM
    AccessioniPrimary (citable) accession number: Q99W31
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3