Reviewed, UniProtKB/Swiss-Prot Q99VX9 (TAGA_STAAM)

Names and origin

Protein names

Recommended name:
    Putative N-acetylmannosaminyltransferase
    EC=2.4.1.187
Alternative name(s):
    UDP-N-acetylmannosamine transferase
    N-acetylglucosaminyldiphospho-undecaprenol N-acetyl-beta-D-mannosaminyltransferase
    Major teichoic acid biosynthesis protein A

Gene names

Name:	tagA
Ordered Locus Names:	SAV0636

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, a key lipid intermediate in the de novo synthesis of teichoic acid Potential.
Catalytic activity	UDP-N-acetyl-D-mannosamine + N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol.
Pathway	Cell wall biogenesis; poly(glycerol phosphate) teichoic acid biosynthesis.
Subcellular location	Secreted › cell wall By similarity.
Sequence similarities	Belongs to the glycosyltransferase 26 family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Teichoic acid biosynthesis
Cellular component	Secreted
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Putative N-acetylmannosaminyltransferase		PRO_0000208442

Sequences

	Sequence		Length	Mass (Da)
	Q99VX9-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 99C014388CFED0BB	FASTA	254	29,133
	10 20 30 40 50 60 MTVEERSNTA KVDILGVDFD NTTMLQMVEN IKTFFANQST NNLFIVTANP EIVNYATTHQ 70 80 90 100 110 120 AYLELINQAS YIVADGTGVV KASHRLKQPL AHRIPGIELM DECLKIAHVN HQKVFLLGAT 130 140 150 160 170 180 NEVVEAAQYA LQQRYPNISF AHHHGYIDLE DETVVKRIKL FKPDYIFVGM GFPKQEEWIM 190 200 210 220 230 240 THENQFESTV MMGVGGSLEV FAGAKKRAPY IFRKLNIEWI YRALIDWKRI GRLKSIPIFM 250 YKIAKAKRKI KKAK

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000017 Genomic DNA. Translation: BAB56798.1.
RefSeq	NP_371160.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q99VX9.
Protein family/group databases
CAZy	GT26. Glycosyltransferase Family 26.
Genome annotation databases
GeneID	1120609.
GenomeReviews	Gene locus SAV0636 in contig BA000017_GR.
KEGG	sav:SAV0636.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q99VX9.
OMA	NPEIVDY.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV0636-MON.
Family and domain databases
InterPro	IPR004629. WecB_TagA_CpsF. [Graphical view]
Pfam	PF03808. Glyco_tran_WecB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00696. wecB_tagA_cpsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TAGA_STAAM

Accession

Primary (citable) accession number: Q99VX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)