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Protein

Methionine import ATP-binding protein MetN 2

Gene

metN2

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine import ATP-binding protein MetN 2UniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:metN2UniRule annotation
Ordered Locus Names:SAV0837
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002703961 – 341Methionine import ATP-binding protein MetN 2Add BLAST341

Proteomic databases

PaxDbiQ99VG8.

2D gel databases

World-2DPAGE0002:Q99VG8.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).UniRule annotation

Protein-protein interaction databases

STRINGi158878.SAV0837.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi247 – 255Combined sources9
Beta strandi264 – 274Combined sources11
Helixi276 – 287Combined sources12
Beta strandi292 – 301Combined sources10
Beta strandi304 – 314Combined sources11
Helixi318 – 330Combined sources13
Beta strandi334 – 340Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CEDX-ray2.15A/B/C247-341[»]
ProteinModelPortaliQ99VG8.
SMRiQ99VG8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99VG8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 241ABC transporterUniRule annotationAdd BLAST240

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEI. Bacteria.
COG1135. LUCA.
KOiK02071.
OMAiAEVITNV.
PhylomeDBiQ99VG8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR026253. ABC_MetN.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017908. ABC_transprt_methionine_MetN_C.
IPR018449. NIL_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF186. PTHR24220:SF186. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
PF09383. NIL. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00930. NIL. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51264. METN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99VG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIELKEVVKE YRTKNKEVLA VDHVNLSIRA GSIYGVIGFS GAGKSTLIRM
60 70 80 90 100
FNHLEAPTSG EVIIDGDHIG QLSKNGLRAK RQKVNMIFQH FNLLWSRTVL
110 120 130 140 150
KNIMFPLEIA GVPRRRAKQK ALELVELVGL KGREKAYPSE LSGGQKQRVG
160 170 180 190 200
IARALANDPT VLLCDEATSA LDPQTTDEIL DLLLKIREQQ NLTIVLITHE
210 220 230 240 250
MHVIRRICDE VAVMESGKVI EHGPVTQVFE NPQHTVTKRF VKEDLNDDFE
260 270 280 290 300
TSLTELEPLE KDAYIVRLVF AGSTTTEPIV SSLSTAYDIK INILEANIKN
310 320 330 340
TKNGTVGFLV LHIPYISSVD FGKFEKELIE RQVKMEVLRH G
Length:341
Mass (Da):38,259
Last modified:June 1, 2001 - v1
Checksum:i9E14C5F116943E48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56999.1.
RefSeqiWP_000571207.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56999; BAB56999; SAV0837.
KEGGisav:SAV0837.
PATRICi19562362. VBIStaAur52173_0862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56999.1.
RefSeqiWP_000571207.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CEDX-ray2.15A/B/C247-341[»]
ProteinModelPortaliQ99VG8.
SMRiQ99VG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0837.

2D gel databases

World-2DPAGE0002:Q99VG8.

Proteomic databases

PaxDbiQ99VG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56999; BAB56999; SAV0837.
KEGGisav:SAV0837.
PATRICi19562362. VBIStaAur52173_0862.

Phylogenomic databases

eggNOGiENOG4108JEI. Bacteria.
COG1135. LUCA.
KOiK02071.
OMAiAEVITNV.
PhylomeDBiQ99VG8.

Miscellaneous databases

EvolutionaryTraceiQ99VG8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR026253. ABC_MetN.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017908. ABC_transprt_methionine_MetN_C.
IPR018449. NIL_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF186. PTHR24220:SF186. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
PF09383. NIL. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00930. NIL. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51264. METN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMETN2_STAAM
AccessioniPrimary (citable) accession number: Q99VG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.