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Q99VA6 (FABF_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2
EC=2.3.1.179
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase II
Beta-ketoacyl-ACP synthase II
Short name=KAS II
Gene names
Name:fabF
Ordered Locus Names:SAV0984
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity.

Catalytic activity

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4144143-oxoacyl-[acyl-carrier-protein] synthase 2
PRO_0000180321

Sites

Active site1651 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99VA6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 46C0005B584824C5

FASTA41443,725
        10         20         30         40         50         60 
MSQNKRVVIT GMGALSPIGN DVKTTWENAL KGVNGIDKIT RIDTEPYSVH LAGELKNFNI 

        70         80         90        100        110        120 
EDHIDKKEAR RMDRFTQYAI VAAREAVKDA QLDINDNTAD RIGVWIGSGI GGMETFEIAH 

       130        140        150        160        170        180 
KQLMDKGPRR VSPFFVPMLI PDMATGQVSI DLGAKGPNGA TVTACATGTN SIGEAFKIVQ 

       190        200        210        220        230        240 
RGDADAMITG GTEAPITHMA IAGFSASRAL STNDDIETAC RPFQEGRDGF VMGEGAGILV 

       250        260        270        280        290        300 
IESLESAQAR GANIYAEIVG YGTTGDAYHI TAPAPEGEGG SRAMQAAMDD AGIEPKDVQY 

       310        320        330        340        350        360 
LNAHGTSTPV GDLNEVKAIK NTFGEAAKHL KVSSTKSMTG HLLGATGGIE AIFSALSIKD 

       370        380        390        400        410 
SKVAPTIHAV TPDPECDLDI VPNEAQDLDI TYAMSNSLGF GGHNAVLVFK KFEA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000017 Genomic DNA. Translation: BAB57146.1.
RefSeqNP_371508.1. NC_002758.2.

3D structure databases

ProteinModelPortalQ99VA6.
SMRQ99VA6. Positions 4-414.
ModBaseSearch...

Protein-protein interaction databases

STRING158878.SAV0984.

2D gel databases

World-2DPAGE0002:Q99VA6.

Proteomic databases

PRIDEQ99VA6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB57146; BAB57146; SAV0984.
GeneID1120959.
KEGGsav:SAV0984.
PATRIC19562659. VBIStaAur52173_1010.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0304.
HOGENOMHOG000060166.
KOK09458.
OMACEATITP.
ProtClustDBCLSK885050.

Enzyme and pathway databases

BioCycSAUR158878:GJJ5-1002-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFPIRSF000447. KAS_II. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR03150. fabF. 1 hit.
PROSITEPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABF_STAAM
AccessionPrimary (citable) accession number: Q99VA6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2001
Last modified: May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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