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Q99VA6

- FABF_STAAM

UniProt

Q99VA6 - FABF_STAAM

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

fabF

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity

    Catalytic activityi

    (Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei165 – 1651PROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-ketoacyl-acyl-carrier-protein synthase II activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-1002-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179)
    Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase II
    Beta-ketoacyl-ACP synthase II
    Short name:
    KAS II
    Gene namesi
    Name:fabF
    Ordered Locus Names:SAV0984
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4144143-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180321Add
    BLAST

    Proteomic databases

    PRIDEiQ99VA6.

    2D gel databases

    World-2DPAGE0002:Q99VA6.

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV0984.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99VA6.
    SMRiQ99VA6. Positions 4-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG0304.
    HOGENOMiHOG000060166.
    KOiK09458.
    OMAiNPDEVQY.
    OrthoDBiEOG6DG2SR.
    PhylomeDBiQ99VA6.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000447. KAS_II. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR03150. fabF. 1 hit.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99VA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQNKRVVIT GMGALSPIGN DVKTTWENAL KGVNGIDKIT RIDTEPYSVH    50
    LAGELKNFNI EDHIDKKEAR RMDRFTQYAI VAAREAVKDA QLDINDNTAD 100
    RIGVWIGSGI GGMETFEIAH KQLMDKGPRR VSPFFVPMLI PDMATGQVSI 150
    DLGAKGPNGA TVTACATGTN SIGEAFKIVQ RGDADAMITG GTEAPITHMA 200
    IAGFSASRAL STNDDIETAC RPFQEGRDGF VMGEGAGILV IESLESAQAR 250
    GANIYAEIVG YGTTGDAYHI TAPAPEGEGG SRAMQAAMDD AGIEPKDVQY 300
    LNAHGTSTPV GDLNEVKAIK NTFGEAAKHL KVSSTKSMTG HLLGATGGIE 350
    AIFSALSIKD SKVAPTIHAV TPDPECDLDI VPNEAQDLDI TYAMSNSLGF 400
    GGHNAVLVFK KFEA 414
    Length:414
    Mass (Da):43,725
    Last modified:June 1, 2001 - v1
    Checksum:i46C0005B584824C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB57146.1.
    RefSeqiNP_371508.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB57146; BAB57146; SAV0984.
    GeneIDi1120959.
    KEGGisav:SAV0984.
    PATRICi19562659. VBIStaAur52173_1010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB57146.1 .
    RefSeqi NP_371508.1. NC_002758.2.

    3D structure databases

    ProteinModelPortali Q99VA6.
    SMRi Q99VA6. Positions 4-414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV0984.

    2D gel databases

    World-2DPAGE 0002:Q99VA6.

    Proteomic databases

    PRIDEi Q99VA6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB57146 ; BAB57146 ; SAV0984 .
    GeneIDi 1120959.
    KEGGi sav:SAV0984.
    PATRICi 19562659. VBIStaAur52173_1010.

    Phylogenomic databases

    eggNOGi COG0304.
    HOGENOMi HOG000060166.
    KOi K09458.
    OMAi NPDEVQY.
    OrthoDBi EOG6DG2SR.
    PhylomeDBi Q99VA6.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci SAUR158878:GJJ5-1002-MONOMER.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000447. KAS_II. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR03150. fabF. 1 hit.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699.

    Entry informationi

    Entry nameiFABF_STAAM
    AccessioniPrimary (citable) accession number: Q99VA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3