ID   TYRA_STAAM              Reviewed;         363 AA.
AC   Q99UB6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Prephenate dehydrogenase;
DE            Short=PDH;
DE            EC=1.3.1.12;
GN   Name=tyrA; OrderedLocusNames=SAV1365;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21311952; PubMed=11418146; DOI=10.1016/S0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I.,
RA   Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K.,
RA   Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M.,
RA   Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M.,
RA   Ogasawara N., Hayashi H., Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus
RT   aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- CATALYTIC ACTIVITY: Prephenate + NAD(+) = 4-hydroxyphenylpyruvate
CC       + CO(2) + NADH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; L-
CC       tyrosine from prephenate: step 1/2.
CC   -!- SIMILARITY: Contains 1 prephenate/arogenate dehydrogenase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BA000017; BAB57527.1; -; Genomic_DNA.
DR   RefSeq; NP_371889.1; -.
DR   GeneID; 1121340; -.
DR   GenomeReviews; BA000017_GR; SAV1365.
DR   KEGG; sav:SAV1365; -.
DR   HOGENOM; Q99UB6; -.
DR   OMA; Q99UB6; QRAIRWG.
DR   BioCyc; SAUR158878:SAV1365-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; Prephen_DH; 1.
DR   Pfam; PF02153; PDH; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NAD; Oxidoreductase; Tyrosine biosynthesis.
FT   CHAIN         1    363       Prephenate dehydrogenase.
FT                                /FTId=PRO_0000282658.
FT   DOMAIN        2    291       Prephenate/arogenate dehydrogenase.
FT   NP_BIND       3     33       NAD (Potential).
SQ   SEQUENCE   363 AA;  40397 MW;  8867E851BCE816C6 CRC64;
     MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADTSQLD KAKSIGIINE KCLNYSEAIK
     KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA MIQQHESNLL KHNIHLVSGH
     PMAGSHKSGV LNAKKHLFEN AYYILVYNEP RNEQAANTLK ELLSPTLAKF IVTTAEEHDY
     VTSVVSHLPH IVASSLVHVS QKNGQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK
     TYILEMIRQL KSQFQDLERL IESNDSEKLL SFFAQAKSYR DALPAKQLGG LNTAYDLYVD
     IPDESGMISK VTYIMSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER GMQALSDFDC
     YIQ
//