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Q99U74 (ODO1_STAAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:odhA
Ordered Locus Names:SA1245
OrganismStaphylococcus aureus (strain N315) [Complete proteome] [HAMAP]
Taxonomic identifier158879 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9109102-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
PRO_0000162178

Sequences

Sequence LengthMass (Da)Tools
Q99U74 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7803AAED537CF247

FASTA910103,112
        10         20         30         40         50         60 
MTNERKEVSE APVNFGANLG LMLDLYDDFL QDPSSVPEDL QVLFSTIKRV MRLIDNIRQY 

        70         80         90        100        110        120 
GHLKADIYPV NPPKRKHVPK LEIEDFDLDQ QTLEGISAGI VSDHFADIYD NAYEAILRME 

       130        140        150        160        170        180 
KRYKGPIAFE YTHINNNTER GWLKRRIETP YKVTLNNNEK RALFKQLAYV EGFEKYLHKN 

       190        200        210        220        230        240 
FVGAKRFSIE GVDALVPMLQ RTITIAAKEG IKNIQIGMAH RGRLNVLTHV LEKPYEMMIS 

       250        260        270        280        290        300 
EFMHTDPMKF LPEDGSLQLT AGWTGDVKYH LGGIKTTDSY GTMQRIALAN NPSHLEIVAP 

       310        320        330        340        350        360 
VVEGRTRAAQ DDTQRAGAPT TDHHKAMPII IHGDAAYPGQ GINFETMNLG NLKGYSTGGS 

       370        380        390        400        410        420 
LHIITNNRIG FTTEPIDARS TTYSTDVAKG YDVPIFHVNA DDVEATIEAI DIAMEFRKEF 

       430        440        450        460        470        480 
HKDVVIDLVG YRRFGHNEMD EPSITNPVPY QNIRKHDSVE YVFGKKLVNE GVISEDEMHS 

       490        500        510        520        530        540 
FIEQVQKELR QAHDKINKAD KMDNPDMEKP AELALPLQAD EQSFTFDHLK EINDALLTYP 

       550        560        570        580        590        600 
DGFNILKKLN KVLEKRHEPF NKEDGLVDWA QAEQLAFATI LQDGTPIRLT GQDSERGTFS 

       610        620        630        640        650        660 
HRHAVLHDEQ TGETYTPLHH VPDQKATFDI HNSPLSEAAV VGFEYGYNVE NKKSFNIWEA 

       670        680        690        700        710        720 
QYGDFANMSQ MIFDNFLFSS RSKWGERSGL TLFLPHAYEG QGPEHSSARL ERFLQLAAEN 

       730        740        750        760        770        780 
NCTVVNLSSS SNYFHLLRAQ AASLDSEQMR PLVVMSPKSL LRNKTVAKPI DEFTSGGFEP 

       790        800        810        820        830        840 
ILTESYQADK VTKVILATGK MFIDLKEALA KNPDESVLLV AIERLYPFPE EEIEALLAQL 

       850        860        870        880        890        900 
PKLEEVSWVQ EEPKNQGAWL YVYPYVKVLV ADKYDLSYHG RIQRAAPAEG DGEIHKLVQN 

       910 
KIIENALKNN 

« Hide

References

[1]"Whole genome sequencing of meticillin-resistant Staphylococcus aureus."
Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. expand/collapse author list , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K.
Lancet 357:1225-1240(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: N315.
[2]"Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
Submitted (OCT-2007) to UniProtKB
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: N315.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000018 Genomic DNA. Translation: BAB42505.1.
PIRE89918.
RefSeqNP_374526.1. NC_002745.2.

3D structure databases

ProteinModelPortalQ99U74.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING158879.SA1245.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB42505; BAB42505; BAB42505.
GeneID1124084.
KEGGsau:SA1245.
PATRIC19574740. VBIStaAur116463_1339.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMAGFTTAPH.
OrthoDBEOG6V1M1F.

Enzyme and pathway databases

BioCycSAUR158879:GJCB-1312-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_STAAN
AccessionPrimary (citable) accession number: Q99U74
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families